Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

95 million worldwide have undergone sterilization, 6 million of the in the US, and on the North American continent 800,000 sterilizations are performed annually. Since 1972, sterilization has been available liberally in Czechoslovakia. 85% of women bear 2 children by age 30, and more than 40% of abortions are repeat abortions, a large percentage of them for women 30. Microsurgery can restore fertility in 50-70% of cases. The negative effect of tubal sterilization on the menstrual cycle was studied in a caseload of 52,026 operations at 45 institutes in 24 countries. 1555 women aged 25-34 with a parity of 2-6 children were selected, and they were followed up for 3 cycles prior and 3 cycles after sterilization. 82% claimed regular menstruation, 54% had irregularity, in 8% irregularity changed after the operation, and in 5% the regular cycle became irregular. In 26%, the days of bleeding decreased, and they increased in 22%. In 2 groups of 86 women each who underwent tubal ligation and hysterectomy in the course of Cesarean section, postoperative infection was 9.3% with hysterectomy and 19.7% with tubal ligation. The negative effect of tubal sterilization on ovarian steroid genesis was shown in 112 women under age 46 with regular menstruation 2 years subsequently: urogenital, cardiovascular, and psychological disorders occurred. In a group of 59 women 41 and another group of 59 women aged 20-41, a significant drop of total estrogen excretion was found 24 hours after sterilization. In another 14 cases, depression and chronic mastopathy developed 2 years after the procedure, necessitating bilateral mastectomy; 3 years later osteoporosis occurred; 4 years later hemotological dysfunction ensued, and another 2 years later angina pectoris developed. In another 15 women, postoperational hypoestrinism was demonstrated after breast carcinoma surgery. A comparative study of 1107 sterilized women and 530 controls showed no change in the regularity or intensity of menstruation; however, dysmenorrhea increased: 10.8% in the sterilized caseload vs. 2.1% in controls. According to some studies, the restoration of fertility was possible in 80% of cases.
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PMID:[Is tubal sterilization harmful to the health of women?]. 220 90

The author outlines a safe diagnostic strategy for the symptom of chronic constipation, conforming to Australian Family Physician's series on common problems in general practice. The constipation is most commonly idiopathic, especially the simple form related to inadequate dietary fibre and bad habit. It is vital not to miss colonic or anorectal carcinoma. Important causes to consider include drugs (self administered or prescribed), hypothyroidism and depression.
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PMID:Constipation. 227 Sep 93

Depressed adenoma of the stomach, whose gross appearance is similar to that of type IIc early gastric carcinoma, was detected in 40/357, or 11%, of gastric resection preparations. Depressed adenoma is primarily found in the two distal thirds and the lesser curvature of the stomach. It presents as a flat brownish depression and measures between 2 and 39 mm across (mean 13 mm). Histology typically reveals tubular adenoma with closely spaced atypical columnar epithelial cells of the intestinal type. Depressed adenoma probably arises from pre-existing depressed lesions (erosions, ulcer scars, atrophic zones) rather than from conventional protuberant adenoma. Depressed adenoma appears to show a greater tendency for malignant differentiation than do conventional adenomas.
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PMID:[The "depressed adenoma" of the stomach]. 232 10

Depressed adenoma of the stomach, whose gross appearance is similar to that of type IIc early gastric carcinoma, was detected in 40/357, or 11%, of gastric resection preparations. Depressed adenoma is primarily found in the two distal thirds and the lesser curvature of the stomach. It presents as a flat brownish depression and measures between 2 and 39 mm across (mean 13 mm). Histology typically reveals tubular adenoma with closely spaced atypical columnar epithelial cells of the intestinal type. Depressed adenoma probably arises from pre-existing depressed lesions (erosions, ulcer scars, atrophic zones) rather than from conventional protuberant adenoma. Depressed adenoma appears to show a greater tendency for malignant differentiation than do conventional adenomas.
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PMID:["Depressed adenoma" of the stomach]. 239 53

The consequences of altered immuno-competence resulting from anaesthesia and surgery are potentially hazardous to the patient with malignant disease. Malnutrition also produces reduction in cell mediated immunity, a condition which is commonly incurred in patients with neoplastic disorders. Numerous agents have been claimed to stimulate the immune responses but few have proved to be of practical value. This paper reports the use variously of protease inhibitors, using Aprotinin, and post operative nutritional therapy, following major surgical resection for carcinoma - specifically as regards their influence on parameters believed to relate to cell mediated immunity. No clinical, metabolic or immunologic benefit was identified from either method of post operative stimulation of cell mediated immunity, although this study did confirm post operative depression of these parameters. The significance of these changes is unclear but there is no evidence to support an immunological mechanism for either of these approaches being of benefit in clinical practice.
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PMID:Post operative stimulation of cell mediated immunity. 241 48

We report a retrospective study of 15 patients with prostate carcinoma and diffuse bone metastases treated with sodium 32P for palliation of pain at Downstate Medical Center and Kings County Hospital from 1973 to 1978. The response rates, duration of response, and toxicities are compared with those of other series of patients treated with 32P and with sequential hemibody irradiation. The response rates and duration of response are similar with both modalities ranging from 58 to 95% with a duration of 3.3 to 6 months with 32P and from 75 to 86% with a median duration of 5.5 months with hemibody irradiation. There are significant differences in the patterns of response and in the toxicities of the two treatment methods. Both methods cause significant bone marrow depression. Acute radiation syndrome, radiation pneumonitis, and alopecia are seen with sequential hemibody irradiation and not with 32P, but their incidence can be reduced by careful treatment planning. Hemibody irradiation can provide pain relief within 24 to 48 h, while 32P may produce an initial exacerbation of pain. Lower hemibody irradiation alone is less toxic than either upper hemibody irradiation or 32P treatment.
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PMID:Comparison of 32P therapy and sequential hemibody irradiation (HBI) for bony metastases as methods of whole body irradiation. 242 17

A novel antitumor antibiotic, 2a,3,4,5,6,6a,7,11b-octahydro-11-methoxy-12-methyl-3,6-imino-1H-2-oxa-11 c- azanaphth(1,2,3-cd)azulene-5-carboxylic acid monocitrate (quinocarmycin citrate; KW2152) was selected for investigation in a number of experimental tumor systems because of its efficacy against P388 leukemia. In the initial studies with P388 leukemia (i.p.-i.p.), KW2152 gave an increase in life span of greater than 80%. The activity was schedule dependent and daily administration was the most effective. KW2152 caused marginal activity against L1210 leukemia, B16 melanoma, and M5076 sarcoma. The effect on cultured cells suggested that KW2152 was not cross-resistant to Adriamycin (ADM) but was cross-resistant to mitomycin C (MMC); however, KW2152 caused prolongation of life span against mice bearing P388/ADM or P388/MMC. In tests against human tumors xenografted s.c. in nude mice, KW2152 significantly inhibited the growth of MX-1 mammary carcinoma with all tumors cured at i.v. doses of 4.4 mg/kg/day and p.o. doses of 26.2 mg/kg/day given daily for 7 days. KW2152 also inhibited distinct human gastric carcinomas, St-4 and St-15 tumors, and colon carcinoma Co-3 by daily administration for 7 days. Against St-4, KW2152 gave a treated versus control percentage of 27, compared to 52 for cis-diamminedichloroplatinum. Against Co-3, KW2152 was at least as effective as MMC, ADM, cis-diamminedichloroplatinum, and bleomycin, giving a treated versus control percentage of 18 at a dose of 8.6 mg/kg/day given daily for 7 days. KW2152 showed growth inhibitory activity against cultured murine tumors and human cells. The order of in vitro efficacy of KW2152 against murine tumors, P388 leukemia greater than L1210 leukemia, B16 melanoma, correlated with the order of the sensitivity on the i.p.-i.p. systems of these tumors. The 50% inhibitory concentrations against P388 leukemia cells were 5.3 X 10(-6) and 1.1 X 10(-7) M after 1 and 72 h exposure, respectively. KW2152 caused significant inhibition of RNA synthesis after a short time exposure. In P388 leukemia cells exposed for 1 h with KW2152, the 50% inhibitory concentration for RNA synthesis was 10(-5) M, 30-fold less than that for DNA synthesis. White blood cell depression or platelet depression was not significant after administration of the i.v. 10% lethal dose given daily for 7 days. Because of its good activity against human mammary tumor MX-1 and some effectiveness against other gastric and colon carcinomas and its water solubility, a novel antitumor antibiotic, KW2152, is being developed as a Phase I anticancer agent.
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PMID:Antitumor activity of a novel antitumor antibiotic, quinocarmycin citrate (KW2152). 243 18

Two hundred and two patients with bone pain from metastatic cancer were treated with 40 microCi/kg of Sr-89. Patients were followed with pain diaries, records of medication taken, sleep patterns, serial bone scans and a Karnofsky Index. One hundred and thirty-seven patients with adequate followup survived at least 3 months, including 100 with prostate and 28 with breast carcinoma. Eighty of the 100 patients with prostate cancer responded, and 25 of the 28 breast cancer patients improved. Ten patients with prostate cancer and five with breast cancer became pain free. Little hematologic depression was noted. Sr-89 kinetic studies showed that strontium taken up in osteoblastic areas remained for 100 days. The tumor-to-marrow absorbed dose ratio was 10:1.
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PMID:Strontium-89: treatment results and kinetics in patients with painful metastatic prostate and breast cancer in bone. 246 31

Since reduced antithrombin III (AT III) activity are associated with increased risk of thromboembolism, we have determined it in 39 patients with prostatic carcinoma. Pre-treatment levels were determined in 24 patients, 6 additional patients with prostatic carcinoma on estrogen treatment and 9 patients on chlormadinone acetate (CMA) therapy. In 12 of 24 patients we studied AT III levels before and after estrogen therapy was initiated. A significant decrease in AT III activity of 23.5% was found after one month on estrogen treatment, the patients on low doses of estrogen. Recovery of the levels of AT III was found after 6 months treatment even in in 5 of 6 patients who had shown depression of AT III levels initially. CMA treatment did not cause its depression. AT III levels was not connected with the stage of the disease or age of the patient.
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PMID:[Effect of estrogen treatment on antithrombin III activity in patients with carcinoma of the prostate]. 247 2

Rabbit V2 carcinoma tissue is the tumor in which cancer procoagulant activity (CP) was first described, purified and identified as a cysteine proteinase able to activate F X directly. In the present study we show that CP of V2 carcinoma extracts is depressed in its biological activity (although the antigen is present) by warfarin treatment. The biochemical basis for this effect is offered by the identification of Vit.K-dependent gamma-carboxylase in the microsomal fraction of the tumor tissue. V2 carcinoma tissue had very low endogenous substrate(s) of tumor carboxylase in basal conditions but this increased threefold after warfarin. The accumulation of endogenous substrate(s) and the depression of the CP activity by warfarin raises the possibility that CP represents at least one of the substrates for gamma-glutamyl carboxylase in this experimental tumor tissue.
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PMID:Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma. 250 Nov 68


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