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Interhemispheric asymmetry of positive emotional reactions was studied in rats: satisfaction of drinking need and self-stimulation. Successive inactivation of the hemispheres was carried out by potassium spreading depression. Switching off of the right as well as the left hemispheres symmetrically influenced the whole quantity of the water, drunk by the rats to a full thirst satisfaction, i. e. the magnitude of need. However, at different stages of drinking need satisfaction an interhemispheric asymmetry was observed: under a strong drinking motivation the right hemisphere dominated, under a weak motivation--the left one. Switching off of the right hemisphere lowered the frequency of self-stimulation of the lateral hypothalamus and switching off the left one heightened it, testifying to the dominance of the right hemisphere in the reaction of self-stimulation. This reaction was also characterized by asymmetry of the lateral hypothalamus nuclei; reactivity to hemispheres inactivation (decreasing or increasing of self-stimulation frequency) of the right nucleus was more expressed than that of the left one.
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PMID:[Interhemispheric asymmetry of positive emotional reactions in rats]. 319 29

Ethological approach to studying mature P. hamadryas and M. mulatta males has revealed a wide spectrum of changes in individual and zoosocial behaviour in response to the administration of different alcohol doses and stress stimuli. It has been established that neuroendocrine basis for the depression of psychic and locomotor activities developing in conditions of alcohol intoxication and emotional stress is an extremely high release of catecholamines and the increase of glucocorticoid secretion accompanied by a sharp decrease in androgen products. It should be noted that the exposure to stress stimuli during consumption of small alcohol doses intensifies depression-like stress-induced behaviour of monkeys.
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PMID:[Psychopathological and hormonal manifestations of alcoholic intoxication and emotional stress in monkeys]. 359 34

In rats that are food- but not water-deprived, a saccharin "meal" is characterized by a progressive decrease in lap rate as the bout progresses. However, saccharin does not trigger a fixed rate of lapping at any point in the sequence. When rats have only intermittent access to saccharin early in the session, they increase their rates of lapping so that, within each few minutes, the amount of lapping (or some correlate such as volume drunk) is held constant. This happens over a wide range of restriction conditions. And if compensation cannot occur during a period of constraint, then it occurs afterward, promptly and precisely. When constraint is withdrawn, rats drink amounts such that the total amount of drinking (or its correlate), through that point in the ingestive bout, is defended. These findings imply that the controlling system includes (1) an integrator that keeps track of the amount of drinking that has occurred, even across interruptions; and (2) a short-term feedback loop that operates minute by minute within the bout. This loop regulates, not the rate of lapping to be emitted, but the amount of lapping to be done (or its correlate); Thus the decline in responsiveness to saccharin as drinking progresses reflects a depression of this regulated value, not of lap rate per se.
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PMID:Some determinants of the time course of saccharin ingestion in hungry rats. 366 93

The events implicated during a suicidal crisis reveal different depressive patterns sometimes unknown before the suicide: pathological idealisation, pathology of mourning, suicidal identification, Tellenbach's melancholic personality, non-acceptance of growing old, anaclitic depression produce a large number of serious suicides, often facilitated by alcohol intoxication. The mechanisms of violence which persist after the suicidal act and the imaginary position of the person in relation to death are also important risk factors.
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PMID:[Suicide: study of events related to patterns of mental functioning of certain subjects at high risk for suicide. Data from the emergency service of a general hospital]. 382 64

The empirical validity of the MacAndrew Scale was investigated in 200 adolescent males convicted of misdemeanor offenses who were classified according to their pattern of alcohol intoxication. Classification results were comparable to those from studies of adult men--true positive = 80%, false negative = 20%, true negative = 81% and false positive = 19%. An empirical cluster analysis of factor scores from the California Psychological Inventory yielded 14 personality types. About 56% of these cases resembled two character orientations (Emotional Extraversion or Emotional Introversion) that were hypothesized by MacAndrew to mediate addiction-proneness among males. However, 38.7% of these subjects were not alcohol misusers. The hypothesis that Emotional Introverts tend to be classified as false negatives was not supported--true positive = 79% and false negative = 21%. Although MacAndrew's formulation of two character orientations has heuristic value, the present study found alcohol misuse among adolescents with other personality characteristics. Studies of nonoffender adolescent males were recommended to clarify the MacAndrew Scale's sensitivity to the character orientation Emotional Introvert. Consistent with earlier research, the present study found no evidence of high levels of emotional tension in the form of anxiety or depression among adolescent alcohol misusers.
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PMID:Construct validity of the MacAndrew Scale: secondary psychopathic and dysthymic-neurotic character orientations among adolescent male misdemeanor offenders. 399 Feb 98

To determine whether acute alcohol ingestion during pregnancy could affect fetal myocardial function, studies were carried in six chronically catheterized fetal sheep during maternal alcohol infusion. Absolute ethyl alcohol (0.8 ml/kg) was administered to the mother over 10 minutes via the jugular vein. These infusions were repeated every 30 minutes during 3 hours, and peak maternal and fetal blood concentrations close to 200 mg/dl alcohol were reached. Fetal PCO2 decreased from a baseline of 43.15 +/- 3.75 to 36.13 +/- 2.6 torr 1 hour after the start of alcohol infusion (P less than 0.05). Similarly, pH rose from 7.37 +/- 0.027 to 7.44 +/- 0.015 (P less than 0.05). Both values returned to baseline level at the end of alcohol infusion. PO2 remained within physiologic limits. The systolic time intervals of the fetal heart showed a rapid and prolonged modification. The pre-ejection period from 58 +/- 8 to 66 +/- 4 msec (P less than 0.05) during the infusion; this change was related to an increase in the isometric contraction period. The ratio of the pre-ejection period over the ejection time was also significantly increased (P less than 0.01), and remained elevated until the end of the experiment (12 hours). A rise in fetal systolic and diastolic pressures was observed at about 2 hours after the start of the alcohol infusion, and lasted 4 hours. This study suggests that an episode of maternal alcohol intoxication causes rapid depression of fetal myocardial contractility that is maintained several hours after cessation of alcohol ingestion.
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PMID:Effects of maternal alcohol intoxication on fetal circulation and myocardial function: an experimental study in the ovine fetus. 406 54

1. When applied directly to the brain, angiotensin II amide, as either the valine(5) octapeptide, causes rats in normal fluid balance to drink water.2. The drinking response to angiotensin injections is copious, rapid, repeatable within the same test session, and stable over months of testing in the same animal.3. The response is motivationally potent and specific. After injection the animals move directly to the source of water and drink. There is typically no preliminary hyperactivity or subsequent depression. The animals do not eat, gnaw or exhibit other behaviours that are not normally seen during spontaneous drinking. The injections rouse sleeping animals to drink and interrupt eating in animals deprived of food for two days.4. The region of the brain that is most sensitive to angiotensin includes the anterior hypothalamus, the preoptic region, and the septum including the nucleus accumbens.5. Intracranial renin elicited drinking. Bradykinin and vasopressin did not, nor did adrenaline, noradrenaline or aldosterone. In the most sensitive region, sites positive for angiotensin also yielded drinking to carbachol.6. Responses were obtained with 5 ng (ca. 5 p-mole) and occurred reliably with 50 ng angiotensin or more. The dose-response curve for amount drunk rose from 5 to 100 ng and levelled off thereafter. Angiotensin is therefore the most potent dipsogen known and is effective at doses that are reasonably within the concentration range for circulating endogenous angiotensin.7. Injections into the sensitive region of doses of angiotensin that were effective for drinking did not produce peripheral haemodynamic changes in lightly anaesthetized rats.8. This work strengthens the suggestion that angiotensin is a natural hormone of drinking behaviour that participates in extracellular thirst by its release from the kidney and subsequent direct action on a specific chemoreceptive region in the anterior diencephalon and limbic lobe.
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PMID:Drinking induced by injection of angiotensin into the rain of the rat. 432 23

Venereal disease (VD) was probably introduced to New Guinea by Europeans. This paper attempts a description of the correlation between social factors and VD in Port Moresby, Papua New Guinea, where 50 military VD patients, 250 military controls, 200 civilian VD patients, and 30 prostitutes were interviewed either at the VD clinic of the Taurama Hospital, or at the army clinic. Among army patients 62% had gonorrhea and 38% other VDs; 38% had been drinking and 24% were drunk at the time of the contact; in 76% of cases sexual intercourse had been with prostitutes; only 6% of military patients had had previous venereal infection. Among the civilians 91% had acquired their infection from prostitutes; in 51% of cases intercourse occurred out of doors; only 15% of civilians had been previously infected. Of the 30 prostitutes 50% were under 21 and 15 were between 21-30; many were married. The total weekly income from prostitution was much higher than the standard male laborer's weekly salary. The immigration of unaccompanied male laborers from rural areas accounts for the excess male indigenous population at Port Moresby, and it is greatly conducive to the development of prostitution, well established in certain suburbs. Many women who accompany their husband or brothers to the city become prostitutes with their encouragement; these women have no education, are of the lowest social status, and provide their pimp with a substantial income. Among the group of people studied in this article soldiers mainly made contact with professional prostitutes during their leisure time and at one of the well known meeting places. The attitudes of New Guineans to VD is closely related to their degree of education. Among the less educated there is disregard toward some forms of VD, and moderately painful lesions are often self-treated before seeking medical attention. Among patients with moderate education refusal to accept cure was a common feature, but depression was common. Among the better educated hypochondriasis was common, with persistent and undue concern over urethral secretions.
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PMID:Social and psychological aspects of venereal disease in Papua New Guinea. 448 75

The neuropsychiatric manifestations of alcoholism can be amended by neutralizing the somatic effects of alcohol on nervous centers. Tiapride acts electively on the mesolimbic area. Promising results have been obtained with tiapride in the various clinical forms of alcohol intoxication. Sixty patients (40 men and 20 women) were given tiapride for abnormal symptoms due to alcohol. Tolerance was good: no side-effects were recorded, with the exception of extrapyramidal manifestations in one patient. Symptoms due to alcohol abuse were alleviated. Relief of tremor was significant. Tiapride proved helpful in anxiety and depression and caused hallucinations to disappear in 35 cases.
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PMID:[Treatment of alcoholic patients with tiapride]. 629 73

Male moderate drinkers (n = 12) drank ethanol (0.8 g/kg) and then ingested one of the following: apomorphine (5 mg), amantadine (200 mg), or placebo. Subjects were tested on a battery of physiological and behavioral measures using a double-blind, within-subjects, crossover design. Postethanol ingestion of apomorphine significantly increased ethanol's effect on 3 out of the 8 measures employed (divided attention, objective and subjective inebriation ratings) without significantly altering blood ethanol concentrations or the rate of blood ethanol decline. There was no indication that apomorphine antagonized ethanol's effects. In contrast to reports indicating that amantadine antagonized ethanol depression in rodents, amantadine did not significantly alter the degree of ethanol intoxication in humans. The increase in intoxication induced by apomorphine supports suggestions that dopaminergic systems may be involved in mediating ethanol intoxication and that the sobering effect of catecholamine-augmenting drugs results from noradrenergic, rather than combined noradrenergic and dopaminergic, stimulation. Further studies are necessary to elucidate the role of pre- and postsynaptic dopaminergic receptors in mediating these effects.
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PMID:Interaction of apomorphine and amantadine with ethanol in men. 675 Nov 37


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