Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was designed to assess polymorphonuclear neutrophil (PMN) functions such as motility and chemiluminescence (CL) in fifty gastric cancer patients, as well as to determine the correlation of PMN function with extent of disease and the degree of differentiation of the lesions. Furthermore, the effects of surgery and administration of Mitomycin C (MMC) on PMN functions were studied. In early gastric cancer and Stage I disease, the mean values of chemotaxis and CL were elevated in comparison to controls. As the disease progressed, the PMN function decreased and significant depression was noted in Stage IV cases. With respect to the relationship of PMN functions to the grade of differentiation of cancer, patients with papillary adenocarcinoma had significantly elevated mean chemotaxis in response to one of the chemoattractants, while patients with poorly differentiated and signet ring cell carcinomas had significantly lower chemotactic responses to chemoattractants compared to controls. There were no significant differences in CL according to the degree of differentiation of histologic type. Surgical removal of the tumor resulted in a tendency towards improvement of PMN chemotaxis while postoperative administration of MMC resulted in a decrease, but there were no statistically significant differences between responses before and after surgery. No improvement of the CL response was demonstrated approximately four weeks after surgery.
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PMID:Changes in polymorphonuclear leukocyte motility under agarose and luminol-dependent chemiluminescence response in patients with gastric cancer. 609 98

An evaluation of various parameters of the immune system was undertaken in Balb/c mice transplanted with a syngeneic mammary adenocarcinoma. Increasing tumor burdens resulted in a depression of some cell mediated immune functions. In contrast, an augmentation of humoral responses was observed in tumor-bearing mice. A defect in the immunoregulatory mechanism did not appear to be responsible for the elevated humoral response as revealed in suppressor cell experiments. However, flow cytometric analysis of T and B lymphocyte levels in the spleens of mice with mammary tumors indicated that the numbers of Thy 1.2 positive cells were greatly diminished while there was only a slight increase in the proportion of cells bearing surface immunoglobulin. These splenic alterations accompanying tumor growth might be responsible for the altered immune responses observed in tumor-bearing animals.
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PMID:Splenic alterations during mammary tumorigenesis: diverse effects on different immune parameters. 621 6

Inbred RIII mice, known to be infected neonatally with murine mammary tumor virus so that females develop mammary adenocarcinoma by 12-15 months of age, were examined with regard to antisheep red blood cell antibody responses at the cellular level. Female mice, 3-11 months old, compared to male mice of the same ages had consistent and significant depression of the antibody response of their splenocytes. Furthermore, female mice with adenocarcinoma showed an even greater depression of the antibody response. Spleen sizes were consistently increased in females as compared to those of male mice throughout the first year of life. The blastogenic responsiveness of the splenocytes to the B-cell mitogen Escherichia coli lipopolysaccharide and the T-cell mitogen phytohemagglutinin-P was not significantly different between male and female mice during the same periods, although the responses of the older tumor-bearing female mice to phytohemagglutinin-P were lower than those of non-tumor-bearing female mice. A complex relationship between age, sex, and immune responsiveness was evident in these mammary tumor virus-infected mice, which made it difficult to attribute a specific immune event to emergence of the mammary adenocarcinomas in the female as compared to male mice.
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PMID:Age- and sex-related differences in antibody formation and blastogenic responsiveness of splenocytes from RIII mice developing virus-induced mammary adenocarcinoma. 627 37

150 micrograms/day of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) was administered to a total of 8 dogs, (4 mongrels at age of 4 months and 4 beagles at age of 6 months) over a period of 8 months by Kurihara 's method. As a result of the administration, we found development of minute cancer as follows: In 3 animals, male beagle killed at 575th day, male mongrel at 1, 105th days and male mongrel at 1, 245th days, a total of 20 neoplasms of the stomach was found (18 early cancers and 2 advanced cancers). 13 of which being the minute cancer measuring less than 0.5 cm. There were 11 mucosal cancers and 2 submucosal cancers. When classified by the macroscopic pathological type, none was classified as the elevated type (I, IIa types), 5 lesions as the flat type (IIb type), and 8 lesions as the depression type (IIc type). Two lesions of submucosal cancer belonged to IIc type. When classified by the histological type, 2 were classified as papillary adenocarcinoma, 2 as well differentiated tubular adenocarcinoma, 1 as moderately differentiated tubular adenocarcinoma, 5 as poorly differentiated adenocarcinoma and 3 as signet-ring cell carcinoma.
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PMID:[Experimental minute gastric cancer induced by N-ethyl-N'-nitro-N-nitrosoguanidine in dogs]. 633 May 19

A phase II study of m-AMSA in patients with gastric adenocarcinoma was conducted. Twenty-three patients received m-AMSA, 90-120 mg/m2, every 3 weeks. There were no major responses among 20 evaluable patients, although one patient experienced a minor response. Depression of the white blood count was the most prominent toxicity. m-AMSA has little activity in patients with gastric adenocarcinoma.
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PMID:Phase II evaluation of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (m-AMSA) in patients with gastric adenocarcinoma. 689 59

A prospectively randomized trial in advanced gastric and pancreatic carcinoma compared multi-drug chemotherapy, with and without radiotherapy to the local lesion, in terms of median survival and toxicity. Of 29 patients with gastric adenocarcinoma, 14 were randomized to receive 5-FU and Methyl-CCNU, and 15 to receive 5-FU and local radiotherapy to a dose of 4600 rad, and then Methyl-CCNU. Thirty patients with advanced adenocarcinoma of the pancreas were similarly randomized. There was no significant difference between the two arms of the gastric or pancreatic adenocarcinoma groups, with a median survival of 13 months and 11.5 months respectively in gastric carcinoma, and 7.8 months and 7.3 months in pancreatic carcinoma. Complications were minimal in both groups. There was more hematopoietic depression in the radiation-treated patients, but none had radiotherapy discontinued because of toxicity.
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PMID:Multi-drug chemotherapy with and without radiation for carcinoma of the stomach and pancreas: a prospective randomized trial. 702 59

We studied the behavior of the cellular immune system in two types of carcinoma of frequent clinical occurrence: large bowel and gastric cancers. We contrasted both types of neoplasia with respect to the behavior of cellular immunity in the preoperative period, according to the evolutive stage of the tumor. Two hundred and nine subjects were studied: 86 with gastric adenocarcinoma, 63 with adenocarcinoma of colon-rectum and 60 healthy controls. Total lymphocytes were quantitated, as were B and T cell subpopulations, and T cell function by measuring the response to PHA. Summarizing the results, a clear depression in cellular immunity was observed in stage III of gastric cancer. In large bowel cancer the repression of cellular immunity is of lesser magnitude than in gastric cancer.
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PMID:Immunologic study of carcinoma of the digestive tract. Effects of the tumor stage. I. Cellular immunity in the preoperative period. 708 Sep 94

An autoradiographic technique has been developed to determine the percentage of MCF-7 human breast adenocarcinoma cells in double-layer agar (DLA) culture that exhibit nuclear incorporation of 3H-thymidine (3H-TdR) after in vitro drug exposure. Depression of this percentage, termed the labeling index, correlated closely with colony count inhibition--relative to the respective control values--for cultures exposed to each of several agents including varying concentrations of 5-fluorouracil and adriamycin. If a similar autoradiographic technique can be applied to cultures from human tumor biopsy specimens, this may then lead to a clinically useful chemosensitivity assay especially applicable when DLA-cultured cell quantities are small.
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PMID:Methods for determining chemosensitivity of MCF-7 cells in double-layer agar culture: labeling index depression and colony count inhibition. 715 82

A series of 24 experiments was carried out, in which treatment effect was determined in vivo on rats bearing measurable implants of 13762 adenocarcinoma treated with a variety of chemotherapeutic agents, alone or in combination. In 11 experiments, a reduction in mean tumor area was observed after treatment (response), while 13 showed no such effect (no response). For each experiment, cells from tumor-bearing animals were placed in suspension culture (10 experiments) or in two-layer soft-agar culture (14 experiments) after 24 h of exposure to drug-containing plasma or control plasma. Cells were harvested from cultures at 24-h intervals thereafter for determination of the thymidine labeling index in treated versus control populations. The sum of labeling indices in control plasma divided by that in treated plasma was determined to combine the available data over time (overall ratio). Critical values for this ratio were defined, which demonstrated significant depression of the labeling index. Significant labeling index depression occurred in nine of 11 experiments where response in vivo occurred, and in one of 13 in which no response was seen (P = 0.0004 by Fisher's exact test). When experiments carried out in soft agar culture or in suspension culture were examined separately, the association of labeling index depression in vitro and response in vivo remained statistically significant. In this model system, labeling index depression by drug-containing plasma is highly predictive of response to therapy.
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PMID:Effects on labeling index as a predictor of response to chemotherapy in the 13762 adenocarcinoma. 716 45

Polyploid carcinoma in the gastric antrum of a Beagle dog induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was sequentially studied by endoscopy and biopsy. Ulcer appeared on the angulus of the stomach at the 28th week and resulted in ulcer scar at the 42nd week. A new depression with atypical glands arose on the ulcer scar at the 69th week, developed elevated border at the 77th week, and progressed to a polyploid lesion at the 90th week. Well-differentiated adenocarcinoma in situ was found in the polyploid lesion at the 97th week. It gradually grew with nodular change of its surface. However, the carcinoma was ulcerated at the 126th week, became an elevated lesion with central depression at the 138th week, and finally regressed at the 154th week. At necropsy on the 202nd week, no carcinoma was found in the stomach.
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PMID:Regression of polyploid carcinoma induced by N-methyl-N'-nitro-N-nitrosoguanidine in the stomach of a dog. 720 19


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