Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mice exposed to a compound containing three phenol derivatives by being housed in cages washed with dilute solutions of the compound, developed considerable depression of the ability to generate plaque forming cells (PFC) in response to sheep erythrocytes (SRBC) in vitro after a four week exposure. The depression became more severe with continued exposure up to fourteen weeks. Administration of orthophenylphenol (OPP), the most abundant derivative in the mixture, resulted in a similar immunodepression at 10 ppm and a slight depression at 1 ppm. Numbers of FcR+ lymphocytes and of macrophages did not appear to be affected by this treatment. The response to a T-dependent and a T-independent antigen were affected similarly, although the latter was depressed less markedly than the former. While these data are only preliminary, they suggest that studies should be performed in detail to elucidate the immunodepressive effects of compounds which are in wide use as household and institutional disinfectants.
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PMID:Phenol derivatives are immunodepressive in mice. 54 52

Exposure of dilute aqueous solutions of tryptophan to near UV light (320 to 390 nm) at subsolar levels yields fluorescent photoproducts capable of inhibiting the growth and differentiation of cultured mouse embryonic fibroblasts and fertilized sea urchin eggs. The ability of these cells to incorporate labelled precursors of protein, RNA, and DNA into their respective macromolecules was markedly inhibited by adding tryptophan preirradiated with near UV light to their incubation media. Thus the inhibition of growth and differentiation of these cells seems to result from a depression of their ability to synthesize macromolecules in the presence of the photoproducts.
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PMID:Inhibition of cell growth by near ultraviolet light photoproducts of tryptophan. 94 71

Weanling male rats received electrolytic lesions in the ventromedial (VMN) and dorsomedial (MDN) hypothalamic nuclei, respectively. A third group served as sham-operated controls (CON). After the two hypothalamic syndromes had been well established, the animals were subjected to (1) a glucose preference test assessing the choice between a 10% w/v and a 35% w/v d-glucose solution, and (2) a test examining the anorexigenic effect of intraperitoneally injected glucose. Weanling rats with VMN lesions, like their mature counterparts, consistently preferred the stronger over the weaker glucose solution throughout the experiment (16 days). Weanling DMN rats, on the other hand, showed a bimodal response, initially like that of the CON rat, toward the end of the experiment, like that of the VMN rats. The weanling CON animals behaved differently from their mature counterparts, inasmuch as their preference for the dilute solution became evident only toward the latter part of the test. An analysis of the calorie intake shows that calories from glucose are similar in all three groups of rats, that the pattern and magnitude of caloric intake in DMN and CON rats are almost identical, and that the total caloric intake (from chow plus glucose) is reduced in the DMN rats because the calorie component from chow is profoundly reduced. In response to intraperitoneally injected glucose, VMN rats show a longer depression of food intake than has been reported for mature VMN rats. The CON and DMN rats recovered quicker and reached preinjection levels of food intake sooner than the VMN rats. The data indicate that in the weanling VMN rat, as in its mature counterpart, the VMN are involved in long-term feeding behavior and do respond to the metabolic signal arising from administered glucose. Nevertheless, the principle factor in their preference seems to be taste rather than solely a metabolic signal. The data show that the DMN are less involved in this sensing and integrating mechanism. In essence, the DMN rat functions quite normally, but its control system is set at a subnormal level.
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PMID:Glucose preference and caloric regulation in weanling rats with ventromedial and dorsomedial hypothalamic lesions. 122 2

Sequential assays for cell-mediated reactivity (CMR) and serum blocking factor (SBF) were performed in a group of 12 melanoma patients who were treated with one or both of the clinically available imidazole carboxamide derivatives, DTIC and TIC Mustard, in order to consider the effects of treatment and changing patterns of disease on the results of in vitro tests in individual patients. Microcytotoxicity assays and the dilute agar colony inhibition test were employed. Of the 12 patients, 8 had no change in CMR and 5 had no change in SBF. Three patients demonstrated a fall in both CMR and SBF to nondetectable levels, and 3 additional patients showed a fall in SBF only. From these results, we conclude that there is no significant depression of CMR in melanoma patients by either of the imidazole carboxamide derivatives used. The results of SBF are less conclusive and more open to question, since it is just a likely that any depression to undetectable levels may be due to a change in disease status rather than to coincident drug use. It appears that microcytotoxicity assay results on individual patients may be fortuitous and difficult to interpret, even though results seen in patients as a group indicate important trends. The microcytotoxicity assay is a useful tool for the experimental tumor immunologist, but its clinical usefulness in individual patients is limited.
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PMID:Evaluation of cell-mediated reactivity and serum blocking factors in melanoma patients on chemotherapy. 123 28

The effect of tramadol on laryngeal reflex activity was assessed in a double-blind cross-over study in six volunteers receiving single oral doses of either codeine 50 mg, tramadol 50 mg or tramadol 100 mg. Laryngeal reactivity was measured by the response to the inhalation of dilute ammonia vapour. The minimum ammonia concentration required to induce a glottic stop was recorded prior to drug administration, and at 15, 30, 45, 60, 90, 120, 150 and 180 min thereafter. Psychometric tests were performed at 0, 45 and 105 min to detect any relationship between central sedation and changes in laryngeal reflex activity. The concentration of ammonia required to induce a glottic stop increased in all treatment groups, but more so in the tramadol groups. The time course suggested that the codeine effect peaked early, and had returned to normal within 2 h. For tramadol 100 mg, laryngeal depression appeared to be still increasing at the end of the 3-h study period. No correlation was found between laryngeal and sedative effects. Tramadol is produced as a racemic mixture, in which one isomer acts through an opioid receptor pathway whilst the other affects noradrenergic and serotonergic mechanisms. Both of these routes of action may be involved in the suppression of the response to experimentally induced cough.
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PMID:A comparison of the effects of codeine and tramadol on laryngeal reactivity. 155 50

An alanine-rich, alpha-helical antifreeze polypeptide (AFP) from the winter flounder and seven analogs with variations in the arrangement of neutral, polar amino acids were synthesized. Circular dichroism studies determined that all of the peptides, except for one containing a proline residue, were essentially 100% alpha-helical. Freezing point depression data, analyzed by three methods, showed that rearrangement of polar residues resulted in moderate to complete loss of anti-freeze activity. It was observed that ice crystals grow as hexagonal bipyramids in dilute solutions, with a constant c to alpha axis ratio of about 3.3. Above a critical threshold concentration, which may depend on the AFP to ice binding constant and reflect the onset of cooperative interactions, growth ceases until the temperature is lowered to the freezing point. We conclude that a specific arrangement of both threonine and asparagine (or aspartic acid) residues is critical for maximal activity and that the AFPs probably bind to the pyramidal faces of ice with a specific orientation. These conclusions are consistent with a recent report (Knight, C. A., Cheng, C. C., and DeVries, A. L. (1991) Biophys. J. 59, 409-418) that a similar AFP adsorbs to the [2021] pyramidal planes of ice in dilute solution.
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PMID:Structure-function relationships in an antifreeze polypeptide. The role of neutral, polar amino acids. 162 10

The dodecamer d-GGTACGCGTACC and four derivatives with GA and IA mispairs in the 6,7 and 5,8 positions have been examined in dilute solution and 0.01-0.1 M sodium chloride. Concentration dependence of Tm, gel electrophoresis, and equilibrium centrifugation indicate that these self-complementary oligomers can form hairpins under the present conditions. Thermal transitions measured in the ultraviolet primarily represent melting of hairpin to coil [cf. Scheffler et al. (1968, 1970)]. The Tm values show little or no depression for 6,7 substitution but rather large depression for 5,8 replacement. We interpret the results to indicate that the 6,7 sequences have two-base loops and five base pair stems and that the 5,8 sequences have four-base loops and four base pair stems. A concurrent theoretical modeling study [Raghunathan et al. (1991) Biochemistry (following paper in this issue)] provides support for this interpretation.
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PMID:Hairpin formation in the self-complementary dodecamer d-GGTACGCGTACC and derivatives containing GA and IA mispairs. 198 65

Severe hypercalcemia is a medical emergency requiring urgent treatment. It most commonly is caused by malignant tumors, as in the case study, but can also be caused by advanced hyperparathyroidism or high serum levels of vitamin D. The patient described in the case study shows clinical evidence of volume contraction due to hypercalcemia-related anorexia and vomiting. His elevated serum concentrations of urea nitrogen and creatinine reflect intravascular volume depletion and hypercalcemia-induced reduction of renal perfusion. He is also likely to have irreversible renal damage as a result of nephrocalcinosis. His central nervous system depression is most likely a result of hypercalcemia, but other central nervous system disorders such as cerebral metastases should be considered. Appropriate treatment would include intravenous fluids to correct volume depletion, dilute extracellular fluid calcium, and promote renal calcium excretion. Before waiting for the effects of volume expansion, the first dose of an inhibitor of bone resorption should be given. The agent of choice now (this may change when second-generation bisphosphonates become available) is plicamycin. Etidronate is a reasonable second choice. Because both drugs require at least 48 hours before their hypocalcemic action is manifest, calcitonin could be used to accelerate the rate of decline of the serum calcium. As the patient becomes more alert, weight-bearing and ambulation should be encouraged. With this combination of therapeutic modalities, this patient's serum calcium level should be corrected within 3 to 5 days. Intermittent injections of mithramycin or etidronate could be given on an outpatient basis approximately once a week in order to maintain the serum calcium within the normal range. One of the most important aspects of treatment in hypercalcemic patients is eradication of the underlying disease, which usually calls for specific antitumor therapy, including chemotherapy, radiation therapy, or surgery. Most of the agents currently available for the correction of hypercalcemia have cumulative toxicities or are only transiently effective and, therefore, their use should be considered a temporizing measure until specific treatment directed at the primary disease takes effect.
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PMID:Management of severe hypercalcemia. 200 13

Many plastic surgery procedures that have traditionally been performed under general endotracheal anesthesia may safely be undertaken using a ketamine-based intravenous sedation technique. General endotracheal anesthesia has many drawbacks, including lack of patient acceptance. Ketamine-based intravenous sedation technique includes the following steps: 1. The patient is placed in a dissociated state using sedative and narcotic agents accompanied by a subanesthetic dose (0.5 mg/kg) of ketamine. 2. A dilute local anesthetic solution (0.25% lidocaine with 1:2,000,000 epinephrine) is infiltrated into the involved tissues to provide anesthesia and hemostasis. 3. The patient is maintained in a tranquil state throughout the procedure by periodic titration of additional doses of sedative and narcotic agents. Advantages of the technique include reducing the need for intubation and its associated hazards, dramatically decreased blood loss due to use of dilute epinephrine solution, reduced recovery time, ability of patients to respond to commands during surgery, avoidance of positioning injuries and increased rapport between patient, surgeon and anesthetist. Disadvantages include respiratory depression and potential for hypoxia. Dissociative intravenous sedation combined with dilute local anesthetic provides a useful addition to the anesthetist's armamentarium.
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PMID:Reducing the need for intubation in plastic surgery. 189 65

Epidural narcotics has been shown to produce profound and long-lasting analgesia. It has been suggested that lipid-soluble narcotics such as fentanyl, because of their short transit time in the CSF, are less likely to be associated with delayed respiratory depression and side effects. We tried to combine low concentrations of fentanyl with bupivacaine to minimize side effects and to see if synergistic effect existed. Forty ASA physical status I or II patients who present for cholecystectomy were included in the trial. Before surgery a thoracic epidural catheter was inserted and pain control began when patients became fully awake and complained of pain in the recovery room after surgery. Patients were randomized in a double-blind fashion to one of four groups. Patients in group I were given epidural infusions of fentanyl 0.001%; patients in group 2 received fentanyl 0.001% mixed with bupivacaine 0.1%; patients in group 3 received fentanyl 0.0005%; patients in group 4 received fentanyl 0.0005% mixed with bupivacaine 0.1%. A continuous epidural infusion of these drugs began at a rate of 10 mL/h after a 5-mL bolus of the solution. Pain relief was assessed with visual analogue pain scale. Respiratory rates, vital signs, and mental status were assessed hourly. Except the group 3, the degree of analgesia achieved was similarly satisfactory in all other groups. There was no respiratory depression developed in either group. Motor block was minimal or absent in all groups. The incidence of nausea and pruritus was significant less in group 3 and group 4. In conclusion, the continuous infusion of dilute bupivacaine with fentanyl provides synergistic analgesia with minimal side effects.
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PMID:Comparison of continuous epidural infusion of fentanyl and fentanyl-bupivacaine for post cholecystectomy pain control. 235 68


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