Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011551 (depersonalization)
 1,117 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 68 year-old man with a history of right thalamic hemorrhage demonstrated radiologically in the pulvinar and posterior portion of the dorsomedian nucleus developed a clinical picture of severe physical sequelae associated with major affective, behavioral and psychic disorders. Affective manifestations were a permanent anxiety-depression state contrasting with indifference to his surroundings. Behavioral changes included marked apathy, inertness and hypersomnia, together with occasional clastic agitated episodes and verbal and gestural stereotypies and soliloquies. Psychic sequelae were psychotic in nature: depersonalization crises, delusions of persecution, multisensorial hallucinations and absurd acts.
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PMID:[Thalamic dementia after a unilateral hemorrhagic lesion of the right pulvinar]. 382 7

Temporal processing of sensory auditory information was investigated in 27 psychiatric patients and 29 normal controls by measuring forced choice thresholds for the right ear to bursts of noise stimuli of three different durations-4, 32, and 128 msec. Psychiatric patients were found to be 5 dB less sensitive than normal controls. A subsequent analysis compared the normal controls with three subgroups of psychiatric patients differentiated according to symptom profile. Those psychiatric patients whose main symptoms were affective showed a shallower threshold duration integration function than did normal controls. Patients whose major symptoms were delusions of persecution and depersonalization showed a slightly steeper slope than normal controls, whereas patients whose major symptom were hallucinations and lack of insight showed the steepest slope.
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PMID:A comparison of psychiatric patients and normal controls on the integration of auditory stimuli. 694 9