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Query: UMLS:C0011551 (depersonalization)
 1,117 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical features of messianic delusions in endogenous psychoses have been retrospectively studied in 75 patients (33 male, 42 female, aged 16-62 years, illness duration from 0.5 to 39 years) with diagnosis paranoid schizophrenia, continuous type (F20.00)--18 patients, attack like progressive type (F20.02)--17 patients, schizoaffective disorder (F25)--27 and acute polymorphic psychotic disorder (F23.03)--13. Being a kind of delusion of grandeur, messianic delusion is characterized by destruction of "self" as break with the past experience, transformation to mythological characters (total depersonalization) and assignment of supernatural power. Its content is similar to apocalyptical, mystical, antagonistic (Manicheam) delusions. Formation of the delusion plot occurred in the framework of hallucinate-paranoid syndrome received its greatest expression in the structure of paraphrenic and oneiroid syndromes. The volume of its content, duration and mechanisms of delusion formation (hallucinative, sensual and delusion of imagination) were defined by a form of schizophrenic psychosis. Sometimes such patients confer social danger and demand more attention from psychiatrists.
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PMID:[Clinical features of messianic delusions in schizophrenic spectrum disorders]. 1673 55

Early psychopathological attempts to characterize the vulnerability to schizophrenia were based on the phenomenological method. From the beginning, phenomenologically-oriented psychopathologists have searched the basic vulnerability underlying schizophrenic phenomena in two main domains: depersonalization and derealisation/desocialization. Schizophrenic persons undergo a special kind of depersonalisation: the living body becomes a functioning body, a thing-like mechanism in which feelings, perceptions, and actions take place as if they happened in an outer space. They also endure a special kind of derealisation/de-socialization: the interpersonal scene becomes like a theatre stage, pervaded with a sense of unreality, on which the main actor is unaware of the plot, out of touch with the role he is acting and unable to make sense of the objects he encounters and of what the other people are doing. Many years later, the mainstream research paradigms employed to investigate the vulnerability concept in schizophrenic psychosis have included genetic studies, birth cohort studies, psychosis proneness, and clinical high risk. We will review these studies and conclude with an outline of future research directions focusing on three main features of the psychopathology of early schizophrenia: anomalies of the pre-reflexive self and of the social self (intersubjectivity), and existential re-orientation.
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PMID:The vulnerability to schizophrenia mainstream research paradigms and phenomenological directions. 2223 64