Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011551 (depersonalization)
 1,117 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The administration of delta9THC intravenously as a premedicant to oral surgery resulted in acute pronounced elevations in anxiety states, a predominance of dysphoria over euphoria, and varying degrees of psychotic-like paranoiac thought. Neural effects that appeared to promote these effects included distortions of perception with sensory delusions, and heightened sensory receptiveness including antalgesic impressions of surgery; autonomic and visceral arousal greater than control or placebo levels; lack of overt behavioral signals of distress due to depersonalization; and time disintegration leading to fear-inducing misinformation about real surgical events. Introverted subjects who generally were inclined to rely on drug solutions to their problems tended to respond poorly to surgical pain and anxiety with delta9THC. These results, obtained from subjects considered to have levels of presurgical apprehension that were average or below average, suggest that the environment in which high doses of cannabinols are experienced is a potent factor in determining the quality of the emotional response. A surgical environment containing even the mild stress of outpatient oral surgery appears to have the potential to precipitate undesirable emotional responses among cannabinol-intoxicated patients. There is continued high-level social use of cannabinols inour society, with an estimate of 40% to 55% among the college-age group seen frequently by oral surgeons. Results of this study suggest that clinicians should be prepared to detect the subtle signs of marijuana intoxication to protect their patients from further psychophysiologic complications during surgery.
 ...
PMID:Emotional response to intravenous delta9tetrahydrocannabinol during oral surgery. 106 33

As many as 180 children aged 4 to 14 years with depression and pain were examined. According to psychopathology senesthopathic pains, pains with vital depersonalization, hallucinatory pains, and pains marked by elements of delirious perception, and undifferentiated pains were distinguished. The authors review some typological varieties of depression and pain: somatoalgic crises associated with somatized depression and pains associated with depression and depersonalization, somatoalgic crises in depression associated with pseudoneurological disorders, somatoalgic crises in the structure of nocturnal fears in the presence of anxious depression, somatoalgic crises in the presence of short-term well-defined episodes of psychomotor excitation or stupor with fear, distress, dysphoria, hallucinations, senesthohypochondriac conditions in the presence of anxiety, somatoalgia in the structure of the depressive and delirious syndrome. Discuss problems of the disease entities, pathogenesis and therapy.
 ...
PMID:[Pain syndrome in children with depression]. 217 25

Dependence to benzodiazepines is difficult to induce in animals but has been induced by high doses in man. Case reports of benzodiazepine dependence are rare compared with the usage of these drugs, but provide no proper epidemiological framework for the estimation of risk. Patients taking these drugs for four months or more may develop symptoms on withdrawal, characterized by anxiety, dysphoria, malaise, depersonalization, and by perceptual changes such as hyperacusis and unsteadiness. In our first study we compared four patients withdrawing from high doses of benzodiazepines with six patients withdrawing from therapeutic doses. In all patients the typical withdrawal syndrome was noted and was equal in intensity in both groups. In the second study, long-term, normal-dose benzodiazepine treatment was discontinued in 24 patients believed to be dependent on their medication. The withdrawal was gradual, placebo-controlled and double-blind. All experienced some form of withdrawal reaction, which ranged from anxiety and dysphoria to moderate affective and perceptual changes. Symptom ratings rose as the drugs were discontinued, but usually subsided to pre-withdrawal levels over the next two to four weeks. Electroencephalograhic (EEG) changes comprised marked reduction in fast-wave activity as the drugs were withdrawn, and an improvement in psychological performance was noted. It is concluded that a risk of dependencies present in all patients taking benzodiazepines even in therapeutic doses for more than a few months. Caution is urged in the prescribing of these drugs.
 ...
PMID:Benzodiazepine dependence. 614 90

The predelusional state (PDS) is defined as the set of psychopathologic events preceding the crystallization of delusions, and includes strange cognitions, moods, conations, and motor acts that may be fleeting and defy description. This review exclusively deals with the historic aspects of PDS. It is noted that during PDS the patient is expected to report experiences for which, on account of their novelty, he may not even have a name. Thus, it is quite likely that according to culture and personal codes and to the conceptual brief of the interviewer, similar experiences might be reported as depersonalization, bodily sensations, dysphoria, changes in perception of reality or time, dissolution of "ego boundaries," etc. It is therefore not surprising that since the 19th century, PDS has been considered a disorder of cognition, emotions, volition, and consciousness.
 ...
PMID:The predelusional state: a conceptual history. 755 68

An association of suicidality and depersonalization with akathisia has been reported, but it is not clear whether these phenomena are specific to akathisia or are nonspecific manifestations of distress. The authors used the Barnes Akathisia Rating Scale, Brief Psychiatric Rating Scale, and Hamilton Rating Scale for Depression (Ham-D) to examine the relationships between suicidality, depersonalization, dysphoria, and akathisia in 68 patients with schizophrenia or schizophreniform disorder. Akathisia was associated with higher scores on the Ham-D ratings of suicidality, depersonalization, and agitation. In a logistic regression model, depressive mood and subjective awareness of akathisia appeared to be the only predictors of suicidality and depersonalization, respectively. These findings support the association between akathisia and both suicidality and depersonalization. However, these symptoms appear to be nonspecific responses to accompanying depressive mood and the subjective awareness of the akathisia syndrome, respectively.
 ...
PMID:The relationship of akathisia with suicidality and depersonalization among patients with schizophrenia. 1151 39

The multidisciplinary research on Salvia divinorum and its chemical principles is analyzed concerning whether the ethnobotany, phytochemistry, mental effects, and neuropharmacology of this sacred psychoactive plant and main principle clarify its experienced effects and divinatory uses. The scientific pursuit spans from the traditional practices, continues with the botanical identification, isolation of active molecules, characterization of mental and neural effects, possible therapeutic applications, and impinges upon the mind-body problem. The departure point is ethnopharmacology and therefore the traditional beliefs, ritual uses, and mental effects of this Mazatec sacred mint recorded during a 1973- 1983 field research project are described. A water potion of crushed leaves produced short-lasting light-headedness, dysphoria, tactile and proprioceptive sensations, a sense of depersonalization, amplified sound perception, and an increase visual and auditory imagery, but not actual hallucinations. Similar effects were described using questionnaires and are attributable to salvinorin A, but cannot be explained solely by its specific and potent brain kappa-opioid receptor agonist activity. Some requirements for a feasible classification and mechanism of action of consciousness-altering products are proposed and include the activation of neural networks comprising several neurochemical systems. Top-down analyses should be undertaken in order to characterize such neural networks and eventually allowing to explore the differential ethnic effects. As is the case for other consciousness-altering preparations, a careful and encompassing research on this plant and principle can be consequential to endeavors ranging from the mind-body problem, a better understanding of shamanic ecstasy, to the potential generation of analgesic, antidepressant, and drug-abuse attenuating products.
...
PMID:Salvia divinorum: a psychopharmacological riddle and a mind-body prospect. 2362 85

[Correction Notice: An Erratum for this article was reported online in Journal of Occupational Health Psychology on Sep 9 2019 (see record 2019-54511-001). In the article, there were wording errors in the Results section. Specifically, we referred to imposing "constraints" when we meant the opposite, namely, relaxing constraints, such as allowing residuals to correlate. We corrected the wording errors, added chi-square statistics, and corrected four small typographic errors bearing on fit statistics (three changes of .001 and one change of .003). The results remain fundamentally the same. All versions of this article have been corrected.] The extent to which burnout refers to anything other than a depressive condition remains an object of controversy among occupational health specialists. In three studies conducted in two different countries and two different languages, we investigated the discriminant validity of burnout scales by evaluating the magnitude of the correlation between (latent) burnout and (latent) depression. In Study 1 (N = 911), burnout was assessed with the Maslach Burnout Inventory-General Survey's Exhaustion subscale and depression with the depression module of the Patient Health Questionnaire (PHQ). In Study 2 (N = 1,386), the Shirom-Melamed Burnout Measure was used to assess burnout and the PHQ, depression. In Study 3 (N = 734), burnout was assessed with the Maslach Burnout Inventory-Educators Survey and depression, with the PHQ and the Center for Epidemiological Studies Depression scale; additionally, anxiety was measured with the Generalized Anxiety Disorder scale. In each study, we examined the burnout-depression association based on confirmatory factor analysis (CFA), controlling for item-level content overlap. In the three studies, latent exhaustion, the core of burnout, and latent depression were highly correlated (correlations ranging from .83 to .88). In Studies 2 and 3, second-order CFAs indicated that depressive (and anxiety) symptoms and the exhaustion and depersonalization components of burnout are reflective of the same second-order distress/dysphoria factor. Our findings, with their replication across samples, languages, and measures, together with meta-analytic findings, cast serious doubt on the discriminant validity of the burnout construct. The implications of burnout's problematic discriminant validity are discussed. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
 ...
PMID:Inquiry into the correlation between burnout and depression. 3151 5

Reports an error in "Inquiry into the correlation between burnout and depression" by Irvin Sam Schonfeld, Jay Verkuilen and Renzo Bianchi (Journal of Occupational Health Psychology, Advanced Online Publication, Apr 04, 2019, np). In the article, there were wording errors in the Results section. Specifically, we referred to imposing "constraints" when we meant the opposite, namely, relaxing constraints, such as allowing residuals to correlate. We corrected the wording errors, added chi-square statistics, and corrected four small typographic errors bearing on fit statistics (three changes of .001 and one change of .003). The results remain fundamentally the same. All versions of this article have been corrected. (The following abstract of the original article appeared in record 2019-18074-001.) The extent to which burnout refers to anything other than a depressive condition remains an object of controversy among occupational health specialists. In three studies conducted in two different countries and two different languages, we investigated the discriminant validity of burnout scales by evaluating the magnitude of the correlation between (latent) burnout and (latent) depression. In Study 1 (N = 911), burnout was assessed with the Maslach Burnout Inventory-General Survey's Exhaustion subscale and depression with the depression module of the Patient Health Questionnaire (PHQ). In Study 2 (N = 1,386), the Shirom-Melamed Burnout Measure was used to assess burnout and the PHQ, depression. In Study 3 (N = 734), burnout was assessed with the Maslach Burnout Inventory-Educators Survey and depression, with the PHQ and the Center for Epidemiological Studies Depression scale; additionally, anxiety was measured with the Generalized Anxiety Disorder scale. In each study, we examined the burnout-depression association based on confirmatory factor analysis (CFA), controlling for item-level content overlap. In the three studies, latent exhaustion, the core of burnout, and latent depression were highly correlated (correlations ranging from .83 to .88). In Studies 2 and 3, second-order CFAs indicated that depressive (and anxiety) symptoms and the exhaustion and depersonalization components of burnout are reflective of the same second-order distress/dysphoria factor. Our findings, with their replication across samples, languages, and measures, together with meta-analytic findings, cast serious doubt on the discriminant validity of the burnout construct. The implications of burnout's problematic discriminant validity are discussed. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
 ...
PMID:"Inquiry into the correlation between burnout and depression": Correction to Schonfeld et al. (2019). 3094 22