Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011551 (depersonalization)
 1,117 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report four observations of women who had acute or subacute psychotic crisis and who were stabilized without any manifestation. In order to delay delivery these women received during pre-partum high doses of beta-mimetic drugs (isoxsuprine and salbutamol). Such a prescription seems to have been responsible of acute and transient psychotic symptoms similar to those observed in drug-induced psychosis (derealisation preceeding depersonalization, visual and auditory hallucinations, anxiety). Recently Gluckman has described a similar case to those reported here. But in his case the conditions of coming out were different and there was a lack of psychotic antecedents. Previous works concerning "psychotic-like" effects of beta-blokers rise the question of possible psychodysleptic effects of beta-mimetic drugs.
 ...
PMID:[Psychosensorial manifestations observed in psychotic patients treated with betamimetic drugs]. 1 32

We present a short review of literature concerning the problem of bromocriptine-induced psychosis A case of toxic psychosis following treatment on bromocriptine in an acromegalic patient who had previously undergone hypophysectomy is also reported. On two occasions after having received low doses of bromocriptine for several months, the patient developed a psychotic syndrome characterized by violent behaviour, auditory hallucinations, paranoid misinterpretation, threatening delusions and depersonalization, which lasted several weeks. On treatment with neuroleptics, the symptoms gradually remitted. In the context of the reviewed literature, an outstanding feature of the case is the absence of psychiatric history, which is not frequent, but not unlikely in the published case-reports. This reassures the authors' on the unespecificity of psychiatric syndromes, broadly discussed in our own and other colleges' references.
 ...
PMID:[A case of toxic psychosis caused by bromocriptine]. 269 95