Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011551 (depersonalization)
 1,117 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A family study was carried out in two groups of patients fulfilling RDC for schizoaffective disorder: in one, a full affective and a full schizophrenic syndrome were simultaneously present; in the other, affective and schizophrenic features appeared within a polymorphic and rapidly changing clinical picture, with depersonalization/derealization and/or confusion. In the first-degree relatives of patients of the former group, the risk of major psychiatric disorders was not significantly different from that of relatives of schizophrenics, whereas in the first-degree relatives of patients of the latter group a low risk for both schizophrenia and major affective disorders, and a relatively high risk for schizoaffective disorders, were observed.
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PMID:A family study of two subgroups of schizoaffective patients. 259 57

Clinical features of messianic delusions in endogenous psychoses have been retrospectively studied in 75 patients (33 male, 42 female, aged 16-62 years, illness duration from 0.5 to 39 years) with diagnosis paranoid schizophrenia, continuous type (F20.00)--18 patients, attack like progressive type (F20.02)--17 patients, schizoaffective disorder (F25)--27 and acute polymorphic psychotic disorder (F23.03)--13. Being a kind of delusion of grandeur, messianic delusion is characterized by destruction of "self" as break with the past experience, transformation to mythological characters (total depersonalization) and assignment of supernatural power. Its content is similar to apocalyptical, mystical, antagonistic (Manicheam) delusions. Formation of the delusion plot occurred in the framework of hallucinate-paranoid syndrome received its greatest expression in the structure of paraphrenic and oneiroid syndromes. The volume of its content, duration and mechanisms of delusion formation (hallucinative, sensual and delusion of imagination) were defined by a form of schizophrenic psychosis. Sometimes such patients confer social danger and demand more attention from psychiatrists.
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PMID:[Clinical features of messianic delusions in schizophrenic spectrum disorders]. 1673 55

The clinical features and symptoms of postpartum psychoses are presented in relation to the classification according to the Research Diagnostic Criteria (RDC) and the concept of "puerperal psychosis". A number of symptoms, ie confusional symptoms, depersonalization, misrecognitions and the "kaleidoscopic" picture are shown to be prominent features. In schizoaffective disorder and unspecified functional psychosis a higher frequency of confusional symptoms, misrecognitions, thematic delusions and a "kaleidoscopic" course of illness was found compared to schizophrenia, mania or depression. The findings of this study support a special status for postpartum psychosis and suggest a link with the concept of cycloid psychosis. In the management of postpartum mental disorder the risk of child-directed aggression, suicide and sudden relapses into psychosis requires special attention.
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PMID:The clinical features of postpartum psychoses. 1969 68