Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Eighteen patients ranging in age from 32-82 years with benign distal esophageal stricture underwent and survived fundic patch operation. Twelve of these patients had undergone esophageal dilatation but without success. Five had had surgery for hiatal hernia using Hill, Belsey or Lortat-Jacob techniques. Middle laparotomy was done in five and left thoracotomy in thirteen. A fundic patch with a 270 degrees fundoplication was performed in seven and a fundic patch with 360 degrees fundoplication in the remaining eleven. The average hospital stay was 12.3 days. Dysphagia disappeared in seventeen and persisted for eight months in one patient. Three patients required instrumental dilatation for a few months. Endoscopic examination, pH study and X-ray fluoroscopy were done. Gastroesophageal reflux was nil in patients treated with Nissen's 360 degrees fundoplication and three of these 7 patients without Nissen's fundoplication had gastroesophageal reflux. Epithelialization of the patched esophageal wound was evident 6 months after the operation.
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PMID:Results of fundic patch operation for severe stricture of the esophagus. 641 87

We herein report our technique for laparoscopic esophageal myotomy combined with Collis gastroplasty and Nissen fundoplication for severe esophageal stenosis. Our patient had experienced vomiting since childhood, and his dysphagia had gradually worsened. He was referred to our department for surgery because of resistance to pneumatic dilation. He was diagnosed with a short esophagus based on the findings of a preoperative upper gastrointestinal series and GI endoscopy. After exposing the abdominal esophagus, esophageal myotomy around the esophago-gastric junction (EGJ) was undertaken to introduce an esophageal bougie into the stomach. Then, stapled wedge gastroplasty was performed, and a short and loose Nissen fundoplication was performed. In addition, the bulging mucosa after myotomy was patched using the Dor method. The patient's postoperative course was uneventful. Most patients with esophageal stricture require subtotal esophagectomy. Laparoscopic surgery for patients with benign esophageal stricture refractory to repeated pneumatic dilation is challenging. However, our current procedure might abrogate the need for invasive esophagectomy for the surgical management of severe esophageal stenosis.
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PMID:A novel laparoscopic approach for severe esophageal stenosis due to reflux esophagitis: how to do it. 2464 33