Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Progress in head and neck cancer (HNC) therapies has improved tumor response, loco-regional control, and survival. However, treatment intensification also increases early and late toxicities. Dysphagia is an underestimated symptom in HNC patients. Impairment of swallowing process could cause malnutrition, dehydration, aspiration, and pneumonia. A comprehensive literature review finalized in May 2012 included searches of electronic databases (Medline, Embase, and CAB abstracts) and scientific societies meetings materials (American Society of Clinical Oncology, Associazione Italiana Radioterapia Oncologica, Associazione Italiana di Oncologia Cervico-Cefalica, American Head and Neck Society, and European Society for Medical Oncology). Hand-searches of HNC journals and reference lists were carried out. Approximately one-third of dysphagia patients developed pneumonia requiring treatment. Aspiration pneumonia associated mortality ranged from 20% to 65%. Unidentified dysphagia caused significant morbidity, increased mortality, and decreased the quality of life. In this review we underline definition, causes, predictive factors of dysphagia and report on pretreatment and on-treatment evaluation, suggesting some key points to avoid underestimation. A multi-parameter assessment of swallowing problems may allow an earlier diagnosis. An appropriate evaluation might lead to a better treatment of both symptoms and cancer.
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PMID:Dysphagia in Head and Neck Cancer Patients: Pretreatment Evaluation, Predictive Factors, and Assessment during Radio-Chemotherapy, Recommendations. 2406 13

Proton pump inhibitors (PPIs) are recommended as first-line therapy for reflux esophagitis. Recent studies documented that more than 25 % of patients have some symptoms of GERD despite PPI therapy. In 2015, a newly developed acid inhibitor, potassium-competitive acid blocker(P-CAB), were started marketing. P-CAB, PPIs, and H2 blockers are antisecretory drugs of gastric acid, and no medicine can reduce gastroesophageal reflux(GER). The cause of GER is the insufficiency of antireflux mechanism of the cardia. Only surgical treatment can repair these situations. Most frequent antireflux procedures for GERD are Nissen and Tou- pet fundoplications. As for postoperative dysphagia, our first choice is laparoscopic Toupet fundoplication (LTF). We herein report our technique of LTF.
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PMID:Laparoscopic antireflux surgery for reflux esophagitis. 3056 35