Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neuronal intranuclear hyaline inclusion disease (NIHID) has been recognized in 14 patients. It usually occurs in the first and second decades but has been seen in the sixth. Both sexes are affected by this sporadic multisystem degenerative disorder that has involved the central and peripheral nervous systems with fibrillar and granular intranuclear inclusions. NIHID appears to be several variants of a multisystem degenerative disease as illustrated by the combination of a spontaneous, degenerative central and peripheral nervous system disorder with neuronal intranuclear inclusions and severe atherosclerotic coronary artery disease in a 23-year-old white man. Beginning at 11 years of age, this patient had experienced diffuse muscle spasms, dysarthria, dysphagia, tremors, ataxia, oculogyric crises, progressive muscle weakness, and atrophy. At autopsy, neuronal intranuclear hyaline inclusions and neuronal loss were seen in his brain, brainstem, cerebellum, spinal cord, bowel, bladder, and esophagus. These fibrillary and granular Cowdry type A and B intraneuronal inclusions were consistent with the diagnosis of NIHID associated with severe coronary atherosclerosis.
J Clin Neuroophthalmol 1987 Dec
PMID:Neuronal intranuclear hyaline inclusion disease associated with premature coronary atherosclerosis. 244 45

A case report of a tuberculous tracheo-oesophageal fistula is described. The patient was successfully treated by antituberculous chemotherapy and a Mousseau-Barbin tube to control dysphagia and choking on deglutition. After 3 months the Mousseau-Barbin tube became displaced and was removed. Closure of the fistula was demonstrated by radiology and endoscopy.
Thorac Cardiovasc Surg 1987 Dec
PMID:Use of a Mousseau-Barbin tube in the management of a tuberculous tracheo-oesophageal fistula. 244 11

Palliation for those with advanced cancer of the esophagus ideally should relieve dysphagia, stop aspiration, and sustain nutrition and hydration. Esophageal intubation with a Celestin prosthesis combined with Janeway gastrotomy is an excellent method for relieving the symptoms of advanced malignancy of the middle and lower thirds of the esophagus. Because intubation and gastrostomy do not require elaborate surgical facilities they can be performed in the community hospital. Although we have carried out the procedure in a small number of patients, palliation achieved has been such that we advocate intubation and gastrostomy as a quick and uncomplicated way to alleviate the symptoms of esophageal cancer patients with late-stage disease.
Ala Med 1989 Dec
PMID:Palliating late-stage esophageal cancer. 248 32

Therapy of inoperable carcinoma of the esophagus and cardia must be based on correction of the dysphagia. On that purpose, a new endoprosthesis (type ESKA-Buess) was used. 57 patients were treated by endoscopic placement of an endoprosthesis. The mortality was 3.5%, patients survived appr. 3 months. All patients experienced a marked improvement in swallowing ability, 61% of our patients could swallow normally. The new endoprosthesis showed no relevant alteration in regard to form and material.
Z Gastroenterol 1989 Dec
PMID:[Endotube insertion for palliation of esophageal and cardia cancer: experiences with a new endoprosthesis]. 248 84

Anomalous origins of the right subclavian and common carotid arteries in a 6-month old Alsatian bitch are described. The first vessel to branch from the aortic arch was a short bicarotid trunk which divided into left and right common carotid arteries. The right common carotid artery was partially occluded at its origin and its function and area of supply was taken over by the right vertebral artery. The right subclavian artery branched directly from the aortic arch and passed dorsally to the oesophagus, forming an incomplete vascular ring around the oesophagus. Although the oesophagus was constricted between the vessel dorsally and the trachea ventrally, it did not cause obstruction or dysphagia. The right vertebral artery was exceptionally large.
J S Afr Vet Assoc 1989 Dec
PMID:Anomalous origins of the right subclavian and common carotid arteries in the dog. 248 31

The clinical and radiological features in four patients with symptomatic mid-esophageal diverticula are reported here. The common clinical symptoms were retrosternal chest pain and dysphagia. Radiologically, three patients had acute obstructions revealed by barium studies and one patient had an esophago-bronchial fistula at the tip of the diverticulum.
Can Assoc Radiol J 1989 Dec
PMID:Esophageal diverticula. 251 90

Schatzki's ring is a distinct anatomical entity associated with hiatal hernia; however, its significance is unclear. Thirty-two patients with a radiologically demonstrated Schatzki's ring were compared with 32 patients with hiatal hernia and no Schatzki's ring. Schatzki's ring was confirmed on endoscopy in 59 percent of patients. Seventy-five percent of patients with Schatzki's ring presented with dysphagia compared with 41 percent of control patients (p less than 0.01). Heartburn and regurgitation were less frequent than in control subjects (38 percent versus 91 percent, p less than 0.0001). Schatzki's ring patients were found to have a lower incidence of proven gastroesophageal reflux on 24-hour pH monitoring. Those with proven reflux were found to have a more efficient lower esophageal sphincter than control patients. Sixty-two percent of Schatzki's ring patients without proven reflux had a history of chronic ingestion of drugs known to be damaging to the esophageal mucosa, whereas only 26 percent of patients with reflux had this history. This was found in 16 percent of controls. Sixty-two percent of Schatzki's ring patients without reflux responded to a single dilatation compared with 37 percent of those with reflux. These findings suggest an etiologic relationship between pill lodgement and Schatzki's ring in patients without reflux and indicate that different therapy should be employed in these patients.
Am J Surg 1989 Dec
PMID:Analysis of thirty-two patients with Schatzki's ring. 258 90

Simultaneous recordings of myoelectric and manometric activities of the esophagus were made in two groups of patients with scleroderma. Group A consisted of patients who suffered from functional dysphagia that had appeared recently, and who had a normal size esophagus when examined radiographically. Patients in group B had complained of functional dysphagia for several years and showed a dilated hypotonic esophagus on x-ray. A control group of five normal subjects was also examined in the same manner. The study was carried out by means of a peroral probe with two pairs of suction-needle electrodes and two manometric side-hole catheters positioned at the same levels as the electrodes. Standard manometric examination of the esophagus was carried out in all patients. Normal subjects after each deglutition showed a propagated burst of spikes in correspondence with the ascending phase of the peristaltic wave, whereas, in the period between deglutitions, rare spikes and no pressure waves were recorded. Group A patients were characterized by the frequent appearance during the interdeglutitive period of spontaneous rhythmic sequences or bursts of spikes associated with pressure waves. In these patients, repetitive nonpropagated spike bursts with a higher than normal amplitude and duration were observed after deglutitions in association with high-amplitude nonpropagated repetitive pressure waves similar to those observed in diffuse esophageal spasm (DES). Five of the seven group B patients showed spike bursts and pressure waves with both amplitude and duration markedly lower than normal. The remaining two patients from group B presented no spike bursts or pressure waves at all. Standard manometry demonstrated findings equivalent to those obtained via electromyography (EMG) in all patients of group B and in only two patients of group A. In conclusion, the functional dysphagia of patients with scleroderma can be attributed to two different motor disorders. The first one is characterized by disorganized myoelectric hyperactivity and may have a manometric appearance similar to that of diffuse spasm. The second one is characterized by a marked decrease in myoelectric activity and corresponds to the classic manometric finding of scleroderma involvement of the esophagus. Both these myoelectric patterns seem to be related to subsequent stages of esophageal scleroderma involvement.
Am J Gastroenterol 1989 Dec
PMID:Esophageal electromyography in scleroderma patients with functional dysphagia. 259 50

Localized thyroid carcinoma involving the base of the tongue was diagnosed in 3 dogs examined because of a midline cervical mass rostroventral to the larynx. These masses had been present for 4 to 12 months and were firm, nonsensitive, and fixed in position. One dog had progressive dysphagia and dyspnea. Masses were surgically excised together with the base of the tongue and portions of the hyoid apparatus. Severe dyspnea that developed immediately after surgery in 1 dog was managed by tracheostomy intubation for 4 days. Transient dysphagia developed in all dogs. Hydration was maintained by IV fluid administration until water and food of gruel consistency could be swallowed 1 to 6 days after surgery. Consistency of food was gradually thickened to normal, as swallowing improved 6 days to 2 months after surgery. One dog developed aspiration pneumonia that resolved after antimicrobial administration and improved swallowing that prevented further aspiration. After 9 months, 3 years, and 6 years, the dogs were clinically normal.
J Am Vet Med Assoc 1989 Dec 01
PMID:Surgical excision of ectopic thyroid carcinoma involving the base of the tongue in dogs: three cases (1980-1987). 259 48

Six hundred cases of tetanus were studied to find out incidence of respiratory complications and to evaluate factors predisposing such complications in tetanus. The incidence of complications was 41 per cent. Infants, patients of more than 40 years of age, smokers, cases with grossly contaminated injuries, short incubation period and short period of onset were more vulnerable. Patients with dysphagia, spasm, associated respiratory diseases and the patients in higher grades were also found to be more susceptible to respiratory complications.
Indian J Med Sci 1989 Dec
PMID:Respiratory complication in tetanus. 263 8


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