Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seventy-one patients with oropharyngeal candidosis received treatment with fluconazole given as a single 50 mg capsule once daily. Of these patients 61 were HIV-antibody positive. Candidosis had been present in nearly all patients for a least one month prior to fluconazole treatment. The duration of daily therapy was 5-20 days and in many cases this was followed by a period of maintenance treatment using 50 mg fluconazole every 48 h. In all 42 symptomatic patients, clinical resolution of the infection occurred within 7 days. Significantly, this included the disappearance of dysphagia in four patients with proven candidal oesophagitis. A marked reduction, or eradication of oral yeasts occurred concomitantly in virtually all patients. Fluconazole was well tolerated by all patients and there were no significant changes in haematological or hepatic parameters that could be attributed to the drug. The results suggest that fluconazole is an appropriate treatment for oropharyngeal candidosis and comparative studies with other agents should now be conducted.
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PMID:Fluconazole in the management of oropharyngeal candidosis in a predominantly HIV antibody-positive group of patients. 283 59

The authors present a case of 60-year-old woman who suffered from a mycosis (Candidosis) infection of the ectopic lingual thyroid gland. Intensive inflammatory process caused enlargement of lingual goiter and dysphagia occurred consequently. Right diagnosis was made after scyntygraphic examination (the presence of lingual thyroid gland only), as well as histopathological and microbiological examinations which revealed the presence of Candida forms. Recovery was achieved after 5 weeks of antifungal treatment--Diflucan during a 2-week initial period, then followed by 3 weeks of local treatment with nystatin.
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PMID:[Mycosis infection (candidiasis) of the lingual thyroid gland]. 959 32