Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011168 (
dysphagia
)
15,644
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Swallowing problems
are often unrecognized in acutely ill patients because of failure to consider abnormalities in the oropharyngeal phase of deglutition. Even the commonly used descriptive term
dysphagia
more often connotes food sticking in the esophagus rather than a disturbance in the physiologic separation of respiratory and digestive tracts during swallowing. To emphasize deglutitional abnormalities, we prefer the term swallowing dysfunction. In this review we describe the potentially fatal consequences of swallowing dysfunction, how dysfunction is recognized clinically, and the conditions in which it should be suspected. Certain aspects of airway and nutritional management are also described because supportive medical care and rehabilitative therapy in the acutely ill often go hand in hand. The methods of evaluation and rehabilitative treatment we describe are relatively simple and easily adapted by the busy staff in a general hospital or intensive care unit. Despite the simplicity of these methods, results are frequently gratifying and can be life saving in acutely ill patients.
...
PMID:Swallowing dysfunction in acutely ill patients. 731 48
We investigated symptoms suggestive of swallowing problems in patients with primary biliary cirrhosis, some of whom displayed features of sicca complex. A prospective study of 95 consecutive patients with primary biliary cirrhosis was conducted at a single teaching hospital using a questionnaire administered over the telephone. Some symptoms of sicca complex (dry mouth and/or dry eyes) were found in 65 patients (68.4%). Subjective xerostomia alone was present in 45 patients (47.4%). The questionnaire revealed an increase in incidence of
dysphagia
in xerostomia subjects, affecting 21 of 45 patients, compared with 6 of 50 non-xerostomia patients. Multivariate logistic regression analysis showed that confounding factors such as age, obesity, cigarette smoking, and medications associated with a dry mouth could not explain these findings. Twenty-eight patients complained of hoarseness, 23 of coughing, and 14 of wheezing, all of which were significantly more frequent than in the 50 patients without xerostomia. Heartburn affected 17 xerostomia patients and 15 non-xerostomia patients, indicating no difference in frequency between these two groups, even after age, obesity, cigarette smoking, and medications associated with heartburn were considered in the multivariate analysis. Acid regurgitation, nausea, and vomiting were also similar in frequency between patients with and without xerostomia.
Swallowing problems
, manifested primarily as
dysphagia
, are common in primary biliary cirrhosis patients who have subjective xerostomia.
Dysphagia
1997
PMID:Primary biliary cirrhosis, sicca complex, and dysphagia. 919 Jan 3
Swallowing disorders are common, especially in the elderly, and may cause dehydration, weight loss, aspiration pneumonia and airway obstruction. These disorders may affect the oral preparatory, oral propulsive, pharyngeal and/or esophageal phases of swallowing.
Impaired swallowing
, or
dysphagia
, may occur because of a wide variety of structural or functional conditions, including stroke, cancer, neurologic disease and gastroesophageal reflux disease. A thorough history and a careful physical examination are important in the diagnosis and treatment of swallowing disorders. The physical examination should include the neck, mouth, oropharynx and larynx, and a neurologic examination should also be performed. Supplemental studies are usually required. A videofluorographic swallowing study is particularly useful for identifying the pathophysiology of a
swallowing disorder
and for empirically testing therapeutic and compensatory techniques. Manometry and endoscopy may also be necessary. Disorders of oral and pharyngeal swallowing are usually amenable to rehabilitative measures, which may include dietary modification and training in specific swallowing techniques. Surgery is rarely indicated. In patients with severe disorders, it may be necessary to bypass the oral cavity and pharynx entirely and provide enteral or parenteral nutrition.
...
PMID:Evaluation and treatment of swallowing impairments. 1079 85
Swallowing impairment
(
dysphagia
) is a frequent sequela of acute stroke; however, the ability to accurately detect
dysphagia
at the bedside and predict which patients may be at risk of dysphagic complications, such as aspiration, remains limited. Despite this, clinical assessment batteries continue to be the first point of assessment for acute
dysphagia
. We examined the predictive value of clinical factors suggestive of swallowing dysfunction in an attempt to identify the important independent clinical signs at initial presentation that are associated with
dysphagia
, aspiration, and the combined variable aspiration and/or penetration (ASPEN) in acute stroke patients. For the purposes of this study,
dysphagia
was defined as a disorder of bolus flow. Aspiration was defined as entry of swallowed material below the level of the true vocal cords which was not expectorated. The clinical items identified as independent predictors of
dysphagia
(measured radiographically) at initial presentation were age > 70 years, male gender, disabling stroke (Barthel score < 60), palatal weakness or asymmetry, incomplete oral clearance, and impaired pharyngeal response (cough/gurgle). The clinical predictors of aspiration (determined radiographically) at initial presentation were delayed oral transit and incomplete oral clearance. Incorporating clinical signs, such as those identified by this study, into clinical assessments of swallowing impairment may increase their predictive utility.
Dysphagia
2001
PMID:Initial clinical and demographic predictors of swallowing impairment following acute stroke. 1145 69
Swallowing impairment
with advancing age is a major health care problem, especially among nursing home residents. An estimated 40% to 60% of nursing home residents have signs of swallowing disorders or
dysphagia
. The high number of nursing home residents with
dysphagia
is, at least in part, caused by patients with swallowing disorders being more likely to be discharged to institutional care. Aging alone does not result in swallowing disorders. Conditions that contribute to swallowing problems include dementia, cerebral vascular accidents, Parkinson's disease, neuromuscular disorders, and some medications. This article discusses the health-related rationale for thickened liquids and fluid viscosities, reviews each phase of the study, and concludes with the practical implications of the study for clinical dietitians.
...
PMID:Research and professional briefs: characterizing process control of fluid viscosities in nursing homes. 1517 97
Swallowing problems
are common in hospital inpatients and may affect morbidity and mortality. Accurate assessment of
dysphagia
is important, allowing optimal management and minimizing potential complications. This article considers the methods of swallow assessment available and ways in which problems can be addressed.
...
PMID:Assessment and management of dysphagia. 1517 43
Swallowing problems
(
dysphagia
) can occur at any age but are most prevalent in elderly individuals and are a growing healthcare concern as the geriatric population expands. Without effective diagnosis and treatment,
dysphagia
may lead to serious medical conditions such as pneumonia, dehydration, and malnutrition. Experts in the field of
dysphagia
met on August 21, 2001, in Rockville, Maryland, to respond to this heightened healthcare need and to determine the course of
dysphagia
research. Presentations at the meeting included epidemiological data, geriatric-specific issues, diagnostic techniques, risk factors for pneumonia, and recent relevant trials. The experts identified outstanding issues in
dysphagia
research, such as study design, population selection, and the standardization of diagnostic and treatment protocols. They designed a clinical trial that represents what they deem is one of the greatest needs in
dysphagia
research, providing a critical springboard for research endeavors with far-reaching implications.
...
PMID:Dysphagia research in the 21st century and beyond: proceedings from Dysphagia Experts Meeting, August 21, 2001. 1763 51
Dysphagia
is an alarming symptom that raises the possibility of stricture or malignancy. This study compares the prevalence and severity of
dysphagia
symptoms in subjects with or without gastroesophageal reflux (GERD). In a population-based study, 500 residents of Cologne between the ages of 20 and 90 years [232 (46%) males and 268 (54%) females] were randomly selected from the city register and sent questionnaires with reflux-related questions. Two hundred sixty-eight replies (54%) were accepted into the study. Of these, 45% were men with a median age of 58 years. The median female age was 54 years. Thirty-four percent of the respondents (n=92) admitted having heartburn symptoms. There was no significant gender-based difference. There was little variation in reflux frequency between individual age groups. Twenty-three (25%) of the 92 respondents with reflux reported symptoms more than twice per week. Forty-five percent of this "reflux" group took medications for their heartburn.
Swallowing difficulties
, predominantly mild, were reported in 11.3% of the respondents.
Dysphagia
was significantly increased in the reflux group (28%) versus the normal group (3%) (p<0.001). Sixteen percent of respondents with mild and 65% of those with moderate to severe reflux symptoms reported additional
dysphagia
symptoms (p<0.001).
Swallowing problems
are common in patients with GERD. Approximately two thirds of patients with long-term and severe reflux symptoms also have
dysphagia
symptoms.
Dysphagia
should always be investigated by a physician.
Dysphagia
2008 Jun
PMID:Prevalence of dysphagia in patients with gastroesophageal reflux in Germany. 1820 88
Swallowing problems
can be relevant, even if underestimated, in Multiple Sclerosis (MS) patients. However, no specific questionnaire for the assessment of
dysphagia
in MS is available. We built a questionnaire (DYsphagia in MUltiple Sclerosis, DYMUS) that was administered to 226 consecutive MS patients (168 F, 58 M, mean age 40.5 years, mean disease duration 10.1 years, mean EDSS 3.1) during control visits in four Italian MS Centres. DYMUS was abnormal in 80 cases (35%). The patients who claimed to have swallowing problems had a significantly higher mean DYMUS score that the other patients (p<0.0001). Mean DYMUS scores were significantly higher in the progressive forms (p=0.003). DYMUS values were significantly correlated to EDSS (p=0.0007). DYMUS showed a very good internal consistency (Cronbach's alpha 0.877). Factor analysis allowed us to sub-divide DYMUS in two sub-scales, '
dysphagia
for solid' and '
dysphagia
for liquid', both of them had a very good internal consistency (Cronbach's alpha 0.852 and 0.870 respectively). DYMUS demonstrated to be an easy and consistent tool to detect
dysphagia
and its main characteristics in MS. It can be used for preliminary selection of patients to submit to more specific instrumental analyses, and to direct toward programs for prevention of aspiration.
...
PMID:The DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis. 1828 May 4
Swallowing problems
following jugular foramen surgery are more common than is often acknowledged and affect up to a third of our patients. They have a significant effect on quality of life. We have become more proactive in this respect and anticipate these problems before they become established. In this article we present our management protocol that has evolved over the past 30 years as a result of our experience treating 134 glomus jugulare tumors. Our current protocol involves a thorough preoperative assessment of swallowing. After jugular foramen surgery, patients undergo further evaluation using fiberoptic endoscopic evaluation of swallowing (FEES), videofluoroscopy, and manometry. Those with prolonged or poorly compensated
dysphagia
are offered rehabilitation surgery. We describe this technique, which has proved beneficial to our patients. Guidelines for management are proposed.
...
PMID:Rehabilitation after treatment for jugular foramen lesions. 1956 47
1
2
3
4
Next >>