Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 67-year-old man temporarily complained of hearing loss and earache in the left side. Afterwards, hearing impairment in the right, pharyngalgia, dysphagia, and ipsilateral facial weakness occurred, however, otological treatments did not completely improve these symptoms except facial weakness. On admission neurological examination revealed right cranial nerve palsies(IX, X, XII), and severe orthostatic hypotension was noted one month after admission. Cerebrospinal fluid revealed pleocytosis(16/mm3), and increased protein level(91 mg/dl), but bacterial, and tuberculotic cultures were negative. Cranial and neck magnetic resonance imaging with gadolinium administration showed diffuse dural thickening. Autonomic dysfunctions were found in cardiovascular and pupillary systems. Plasma noradrenaline level was normal in supine position but noradrenaline infusion test showed denervation hypersensitivity. Additionally pupils showed hypersensitivity to 1.25% epinephrine. These results suggest that lesions were post-ganglionic afferent fibers in both cardiovascular and pupillary systems. Administration of corticosteroid hormone resulted in dramatic improvement of his clinical symptoms including autonomic dysfunctions. Circulation disorder or infiltration of the inflammatory cells to the autonomic nervous system may be the cause of these dysfunctions in this patient.
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PMID:[Pachymeningitis with autonomic dysfunctions: a case report]. 1157 18

In adults, an estimated 4% to 10% of chronic, nonspecific laryngeal disease seen in otolaryngologic clinics is associated with gastroesophageal reflux disease (GERD). Although no such estimates exist in children, many investigators have reported extraesophageal manifestations of GERD, of which the most common is the association of GERD with asthma and chronic cough. A variety of signs and symptoms of otolaryngologic disease also have been attributed to GERD, including hoarseness, laryngitis, chronic rhinitis, sinusitis, globus pharyngeus, recurrent croup, laryngomalacia, stridor, subglottic stenosis, otalgia, vocal cord granulomas, and oropharyngeal dysphagia. However, proof of the association between these manifestations of otolaryngologic disease and GERD is sparse. Furthermore, the manifestations of otolaryngologic disease often occur in the absence of such classic systems of GERD as heartburn or chest pain. This review explores the role of GERD in otolaryngologic disease in children.
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PMID:Pediatric otolaryngologic manifestations of gastroesophageal reflux disease. 1273 48

Dysphagia of greater than 48 h duration is an indication for indirect laryngoscopy and when odynophagia and otalgia occur simultaneously, the possibility of subluxation of the arytenoids demands an urgent ENT assessment. The potential seriousness of laryngeal lesions following intubation obliges us to use the smallest compatible endotracheal tube. The occurrence of pain cervical surgical emphysema and fever suggests a pharyngeal lesion necessitating the suspension of oral feeding and the initiation of antibiotic therapy with anaerobic activity, while awaiting possible surgical intervention. There is no argument to use a tooth-guard for each intubation, but tooth fragility must be researched. The incidence of nasal fossa trauma is reduced with the use of nasal packs impregnated with local anaesthetic containing a vasoconstrictor. This allows the introduction of a small flexible lubricated tube. Laryngeal mask-induced sore throat is more common than the more serious injuries. The classical technique of introducing a laryngeal mask of appropriate size (4 for women, 5 for men) in which the cuff is inflated to a leak pressure of 20 cm H(2)O reduces this frequency. The facial mask may cause injuries especially with prolonged use. The incidence of pulmonary aspiration, linked to the action of drugs, raised intra-abdominal pressure; an emergent situation or difficult intubation is decreased with the performance of the Sellick maneuver at intubation, rapid induction and the neutralization of gastric acidity. A meticulous technique of insertion of the, individualized anaesthesia, particular vigilance at the time of decurarisation and position changes and a calm awakening assure its optimal use, unless the Proseal laryngeal mask modifies this point of view.
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PMID:[Lesions to lips, oral and nasal cavities, pharynx, larynx, trachea and esophagus due to endotracheal intubation and its alternatives]. 1294 64

Cervical osteophytes and other hypertrophic changes of the cervical spine may lead to dysphagia, odynophagia, otalgia, and sensation of a foreign body in the throat when they protrude from the anterior edge of the cervical vertebrae to the pharynx or upper esophagus. A fifty-three-year-old male patient presented with a complaint of dysphagia. Physical examination showed no abnormality. Barium esophagography revealed osteophytic spurs in the anterior aspect of C4-5 vertebrae, in close approximation to the inlet of esophagus, obstructing the esophagus passage by external compression. Anti-inflammatory therapy administered for three weeks did not provide relief of the patient's complaint. Surgical treatment recommended was refused by the patient.
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PMID:[Dysphagia due to a cervical osteophyte: a case report]. 1367 92

Family physicians frequently encounter patients with neck lumps. The causes are numerous but in the adult the origin is most often a lymph node, the majority of which are malignant. Inappropriate management may often lead to a very poor outcome. Relevant investigations must therefore be correctly chosen. The risk for a neck lump to be malignant depends mainly on age, male sex, and alcohol and tobacco consumption and to a lesser extent on a family history for head and neck malignancy. Careful medical history looks for symptoms such as dysphagia, pain, dysphonia, otalgia, or weight loss. On physical examination, the location, size, consistency and mobility of the mass is described. A careful inspection of the scalp, skin of the face and mucosal surface of the upper aerodigestive tract is performed followed by palpation. If no inflammatory or tumoral lesion is identified, the next step is to perform a fine needle aspiration biopsy of the neck mass which will most often lead to a definite diagnosis. When this is not the case, an otolaryngology consultation and excisional biopsy should be obtained.
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PMID:[Cervical nodules: diagnosis and management]. 1529 45

Large oropharyngeal concretions--giant tonsillolith--are not very common. Over the last few years only some 50 cases have been reported in the literature. Many tonsilloliths, especially small concretions, are asymptomatic; large concretions, on the contrary, may produce several symptoms. The case is described of a 56-year-old female complaining of dysphagia, odynophagia, sore throat, right otalgia and swelling in right tonsillar fossa. Routine panoramic radiography revealed a radio-opaque area in right tonsil region. Computed tomography of oropharynx was performed and axial slices revealed a calcified cylindrical lesion in posterior pharyngeal region, between palatoglossus and palatopharyngeus muscles. The tonsillolith was easily excised under local anaesthesia. The post-operative course was good with no recurrence. Microscopic examination of the specimen revealed necrotic debris, "ghost" cells, calcifications and inflammatory cells, confirming the diagnosis of tonsillolith. Authors stress that large tonsillar concretions are uncommon, and may be difficult to diagnose since the tonsillolith can also be mistaken for other anatomic and pathologic structures in the oropharyngeal area.
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PMID:Tonsillolith. Case report and review of the literature. 1587 14

A patient with a progressively increasing immobilisation of the cervical spine, severe impaired swallowing (choking), sore throat with referred right-sided otalgia, mild voice disorder and dysphagia due to extrinsic bone compression of the posterior hypopharyngeal wall and oesophagus is presented. Radiographic investigation demonstrated the underlying condition to be a diffuse idiopathic skeletal hyperostosis with prominent and bumpy alteration of the anterior longitudinal ligament impinging the hypopharynx. Via an anterolateral approach towards the cervical spine the anterior irregular part of the ossification was removed and the surface of the spine flattened. The postoperative evolution was uneventful.
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PMID:Choking, sore throat with referred otalgia and dysphagia in a patient with diffuse idiopathic skeletal hyperostosis (DISH). 1608 96

Eagle's syndrome represents a group of symptoms that includes recurrent throat pain, globus pharyngeus, dysphagia, referred otalgia, and neck pain possibly caused by elongation of the styloid process or ossification of the stylohyoid or stylomandibular ligaments. The medical history and physical and radiologic examinations are the main guides to the precise diagnosis. The radiologic diagnostic modality of choice is three-dimensional computed tomography (3-D CT). We describe a case of bilaterally symptomatic Eagle's syndrome that was diagnosed by 3-D CT of the styloid processes and successfully treated with surgery via a transoral approach.
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PMID:Three-dimensional computed tomography and surgical treatment for Eagle's syndrome. 1690 16

A 66-year-old woman was admitted to our hospital because of hoarseness and dysphagia after right earache and pharyngalgia. She showed right glossopharyngeal nerve and vagus nerve palsies, but no other neurological deficits. There was no skin rash within the regions of her ear, oral cavity, pharynx and larynx. Slight increase of mononuclear cells was noted in the cerebrospinal fluid. MR brain imaging was normal. We diagnosed her as zoster sine herpete (ZSH) and treated her with acyclovir, after which she almost completely recovered. The examination of antibodies and DNA of varicella zoster virus (VZV) in the serum and cerebrospinal fluid revealed a pattern of previous zoster infection without evidences of reactivation. However, VZV DNA was detected in auricular skin exudates with PCR. We conclude that PCR analysis of VZV DNA in auricular skin exudates can be a useful diagnostic tool for the diagnosis of zoster sine herpete presenting with painful glossopharyngeal nerve and vagus nerve palsies.
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PMID:[Case of zoster sine herpete presenting with dysphagia diagnosed by PCR analysis of VZV DNA in auricular skin exudates]. 1726 Aug 14

The close proximity of the styloid process to many of the vital neurovascular structures in the neck makes it clinically significant. Abnormal elongation of the styloid process may cause compression on a number of vital vessels and nerves related to it, producing inflammatory changes that include continuous chronic pain in the pharyngeal region, radiating otalgia, phantom foreign body sensation (globus hystericus), pain in the pharyngeal region, and dysphagia. The normal length of the styloid process is usually 2.0-2.5 cm long. We report a dry human skull that showed bilateral styloid processes measuring 6.0 cm on the right side and 5.9 cm on the left side. The variation in dimension of the process and its clinical implication are discussed.
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PMID:An unusually lengthy styloid process. 1730 74


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