Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 38-year-old man hit his forehead against a steel pipe, which made his neck hyperextended. He noticed unsteady gait and dysphagia approximately 6 hours after the accident. On the next day he was admitted. He had a Horner's syndrome, and pharyngeal and palatal weakness on the right side. There were no pyramidal tract signs. He could not balance on his right foot or gait tandemly. Sensation for cold and pin-prick was absent on his left limbs; position sense was intact. Angiography demonstrated an occlusion of the right vertebral artery at the 3rd segment. Cranial MRI demonstrated an infarction in the right lateral medulla. A radiogram demonstrated an atlanto-axial instability. There was an anomalous bone mass between the left superior articular process and the odontoid process. These abnormalities might have precipitated injury of the vertebral artery during the minor neck trauma. The plasma levels of molecular markers for coagulation and fibrinolysis were unremarkable. In contrast, beta-thromboglobulin and platelet factor 4 levels were high, suggesting activated platelet aggregation. To my knowledge, this is the first report showing evidence for platelet activation at the molecular level early in the course of vertebral artery thrombosis following a minor neck trauma.
 ...
PMID:[Wallenberg's syndrome following minor neck trauma: a case associated with atlanto-axial subluxation, an anomaly of the axis, and platelet activation]. 852 48

A 75-year-old man was admitted to our hospital with dysesthesia of the right lip, dysphagia and gait disturbance. He presented with right Wallenberg syndrome and brain MR image showed a fresh infarction in the right lateral medulla. Therapy with heparin and ozagrel sodium was started. For a time his symptom improved a little, but after 8 days he developed re-infarction, thrombocytopenia and DIC, while being treated with heparin for cerebral infarction. Heparin was discontinued, and these symptoms improved quickly. The clinical course and the positive anti-platelet factor 4-heparin complex antibody suggested that these symptoms were caused by heparin-induced thrombocytopenia (HIT). HIT should be included as a differential diagnosis for progression of ischemic stroke under heparin therapy.
 ...
PMID:[A case of heparin-induced thrombocytopenia that worsened preexisting cerebral infarction]. 1551 11