Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To define the clinical course of patients with benign esophageal stricture treated with bougienage, we received the records of 76 patients undergoing dilatation. Patients with the diagnosis of scleroderma and those with previous hiatal hernia repair or gastric surgery were excluded. Initial evaluation included contrast study, esophagoscopy, and biopsy. Patients underwent a series of dilatations until a 44-Fr or larger bougie was passed. Patients were then instructed to return for recurrence of dysphagia. In this group, mean duration of follow-up from the first dilatation was 21.1 months. A total of 569 dilatations were performed with one major complication and no mortality. Benign esophageal stricture recurred in 65% of patients. After two or more recurrences, the likelihood of requiring an additional dilatation was 86--94% after each recurrence. The interval between required dilatations was variable; however, after 8 dilatations, it approximated once monthly. The shorter mean follow-up time of patients requiring a single dilatation (9.7 months) compared to those requiring multiple dilatations (28.8 months) suggests that the recurrence rates noted in this study are underestimations. In spite of high recurrence rates and short recurrence intervals, the low morbidity and absent mortality over long-term follow-up suggests that repeated bougienage is an effective modality for the management of benign esophageal stricture.
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PMID:Clinical course of esophageal stricture managed by bougienage. 711 73

Benign oesophageal stricture is a disabling problem associated with oesophageal surgery, injection sclerotherapy and patients with reflux problems. Fortunately, mechanical dilatation has emerged as an effective treatment of choice. In recent years, balloon dilatation appears to have gained popularity because of its efficacy and safety. This study of 43 patients compares manual dilatation with balloon dilatation. Twenty-one patients underwent manual dilatation with either Eder-Puestow or Gum Elastic dilators. There were 4 failures which were then treated successfully with balloon dilatation. Two other patients developed perforation and needed emergency surgery. Nine patients required 3 or more graduated dilatations within one month. Another group of 22 patients were treated successfully by balloon dilatation without any complications. Ten patients developed recurrent dysphagia and needed another repeat dilatation after an interval averaging 4.5 months. The results show quite conclusively that balloon dilatation is superior to manual dilatation.
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PMID:Evaluation of non-surgical treatment of benign oesophageal stricture. 784 66