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Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

1. Head and neck tumors occur predominantly in men between 50 and 70 years of age who typically abuse tobacco or alcohol. These individuals often have poor oral hygiene and dentition as well as nutritional deficits, and achlorhydria, anemia, and iron and riboflavin deficits are common. 2. The tumor and treatment of head and neck cancer may cause many devastating effects, such as facial disfigurement, dysphagia, alterations in airway and communication, partial or total loss of taste and smell, xerostomia, pain, or fatigue. Treatment and rehabilitation may take months. 3. Although advances in technology and reconstructive surgery have not improved the overall survival rate, they preserve appearance, function, and, ultimately, the patient's quality of life.
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PMID:Head and neck cancer resection and reconstruction: from past to present. 141 30

A procedure is described for quantifying the amount of bolus material retained in the pharynx after completion of a swallow, using radionuclide swallow techniques. Data are derived from scintigraphic time-activity curves. The procedure takes into consideration the differential attenuation of radioactivity through various regions in the body, and expresses the result as a percentage of the total radioactivity in the ingested bolus. Illustrative examples are provided for swallows by normal individuals and patients with head and neck cancer.
Dysphagia 1992
PMID:Scintigraphic quantification of pharyngeal retention following deglutition. 142 23

The incidence of multiple swallows for liquid and paste, and the time delay between multiple swallows, was determined from videofluoroscopic records of modified barium swallow tests. In a comparison of liquid and paste, the overall incidence of multiple swallows did not differ, for either patients with head and neck cancer or normal controls. However, for liquid swallows the incidence in patients with cancer was abnormally high, predominantly in patients with pharyngeal cancer.
Dysphagia 1992
PMID:Multiple swallows and piecemeal deglutition; observations from normal adults and patients with head and neck cancer. 142 30

This study was designed to determine whether swallow rehabilitation outcomes were affected by the type of evaluation procedure utilized by the clinician. The two evaluation techniques compared were the bedside examination and videofluoroscopy (the modified barium swallow). Ten institutions participated in this study, enrolling a total of 103 partial laryngectomized patients, 21 in the bedside arm and 82 in the videofluoroscopy arm. Data on recovery of oral intake were collected weekly. All patients received an X-ray study of swallow at 3 months after the operation. Mean time to oral intake of food was significantly lower in patients assessed with bedside examination. Overall swallow measures of transit times and swallow efficiencies after 3 months revealed significantly better function in the videofluoroscopy group. Results are discussed in terms of the visibility of swallow physiology with the two assessment techniques, the accuracy of therapy planning with the bedside examination versus videofluoroscopy and the ability of head and neck cancer patients to tolerate some aspiration without developing aspiration pneumonia.
Dysphagia 1992
PMID:Impact of the diagnostic procedure on outcome measures of swallowing rehabilitation in head and neck cancer patients. 142 31

We treated 14 patients who had advanced head and neck cancer with an accelerated fractionation schedule of irradiation consisting of two fractions given 6 hours apart. In the morning a volume of 1.7 Gy was given to an area that encompassed the entire tumor, enlarged lymph nodes, and all areas at risk for microscopic disease. Six hours later, 1.1 Gy was given to an area that included only the tumor and any enlarged lymph nodes, with a 2-cm margin. The treatment was well tolerated; of the 13 patients who completed therapy, six did not require a break in therapy, and seven patients did. The median rest period was 2 days. There was no grade 4 toxicity. Grade 3 toxicity included skin changes (one case), mucositis (two), dysphagia (two), weight loss (three), and a decrease in the hemoglobin level (one case). The response rate in the 13 who completed therapy was 13/13 (100%); 11 of the 13 (83%) had a complete response. Only one of the 11 who achieved a complete response had failure at the primary site. At a median follow-up of 24 months, the absolute survival was 7/13 (54%) and the corrected survival was 7/10 (70%). This technique permits radiation therapy to be given on an accelerated schedule without a planned break in treatment. The overall response rate and survival at 2 years was excellent.
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PMID:Accelerated fractionation radiation therapy for advanced squamous cell carcinoma of the head and neck. 189 31

5-FU intra-arterial infusion and simultaneous irradiation can cure head and neck cancer without leaving any functional disturbance. Catheters were inserted into the bilateral superficial temporal arteries in a case of T4 carcinoma of the oral cavity, and this treatment was performed. The patient was a 54-year-old male with squamous cell carcinoma involving the right tonsil, right and left sides of the soft palate, the uvula, right gingiva, right lingual margin, and right buccal mucous membrane. The right soft palate was partially defective. The total dose of intra-arterial 5-FU was 4,000 mg on the right side and 2,600 mg on the left side, and the total dose of irradiation was 40 Gy. After this treatment, residual cancer was found on the right margin of the uvula only. Due to the defect in the soft palate, the effect of intra-arterial infusion was considered to be insufficient for this region, and it was excised together with the surrounding tissue. Rhinolalia aperta remains, but there is no dysphagia, and the course has been good with no evidence of recurrence so far. When it is found that a catheter cannot be readily inserted, it can usually be inserted properly by using a guide wire. For fixing the catheter, a satisfactory result is obtained by cutting the protruding end to 15-20 cm, attaching a connector, and suturing it to the skin of the temporal region.
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PMID:[T4 carcinoma of the oral cavity responsive to bilateral 5-FU intra-arterial infusion and simultaneous irradiation]. 238 62

Anorexia, dysphagia, and dysgeusia are the most prevalent symptoms in head and neck cancer patients during radiation therapy. The patients, who were in poor general condition, suffered marked loss of body weight and consequently were unable to tolerate further anti-cancer treatments. Aggressive nutritional support to the head and neck cancer patients was started in April, 1986 to improve the general condition of these patients in our hospital. The physiological condition of 152 patients who underwent nutritional support were evaluated as a study group (Group I) between August 1986 and May 1987. Group II, 165 patients without nutritional care were evaluated as a control group between August 1985 and May 1986. In Group I, oral supplementary diets or enteral feedings were provided as nutritional support to all of the anorectic patients. Anthropometric measurement and laboratory data were collected in both groups at the several time points. An average of 1.1 kilogram (Kg) and 3.5Kg body weight loss was observed in Group I and Group II, respectively (P less than 0.005). In patients diagnosed with nasopharyngeal carcinoma, the average duration of radiation treatment was 11 days shorter in Group I than that in Group II (42 vs 53 days). In conclusion, aggressive nutritional care performed by a group of clinical staff, which included doctors (radiation oncologist), dietitians and oncologic nurses, was sufficient to improve the general condition of the head and neck cancer patients during radiation therapy and to therefore increase the recovery rate of these patients after radiation treatments.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Clinical evaluation of aggressive nutritional care to head and neck cancer patients during radiation therapy]. 250 13

Tracheopulmonary aspiration is a common occurrence in patients with dysphagia associated with head and neck cancer. We performed quantitative scintigraphic analysis of tracheopulmonary aspiration in 125 patients with head and neck cancer; 58 of these patients had a tracheostomy. Tracheopulmonary aspiration occurred in 58% of patients with a tracheostomy and in 23% of patients without a tracheostomy. In six of seven patients with a tracheostomy, tracheopulmonary aspiration significantly increased when the obturator was removed and, in these patients, occlusion of the tracheostomy tube during feedings eliminated or reduced the complication. Our studies suggest that aspiration can be monitored accurately and conveniently by scintigraphy, and that this technique is useful in the evaluation and management of dysphagia in debilitated patients.
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PMID:Aspiration in patients with head and neck cancer and tracheostomy. 276 41

Nine patients presenting with dysphagia following successful treatment for head and neck cancer with neutron radiotherapy are reviewed. Combined clinical and videofluoroscopic investigation is used to analyse their deficits and provide indications for management. All patients show impairment of both the oral and pharyngeal phases of the swallow, with the exception of one subject who shows signs of focal neurological damage. It is suggested that fibrosis is the underlying cause of dysphagia in the remainder.
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PMID:Dysphagia after fast neutron therapy to the head and neck. 239 Jun 97

Nutrition-related complications of radiotherapy were evaluated in 74 head and neck cancer patients. Subjective changes of mouth dryness, taste, dysphagia, appetite, and food preferences were determined by questionnaire before and at weekly intervals during curative radiotherapy. Changes in body weight during therapy were also recorded. In addition, 24-hour dietary histories were taken from eight patients at the beginning and end of treatment. Results of the study indicate that patients were subjectively aware of nutritional problems prior to therapy and that therapy exacerbated these problems. As many as 25% of the patients experienced oral complications such as taste loss and/or dry mouth prior to initiation of radiotherapy. By the end of radiotherapy, over 80% of the patients were aware of oral and nutritional problems. Patients had an average weight loss of 5 kg prior to therapy; this loss of weight did not change during therapy. Diet histories of eight patients indicate significant caloric deficiencies early and late in radiotherapy. The oral and nutritional problems experienced by patients, even prior to therapy, support the idea that nutritional evaluation and maintenance are important not only during therapy, but prior to radiotherapy as well. Nutritional evaluation should be made a routine, integral part of therapy for every cancer patient.
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PMID:Nutritional consequences of the radiotherapy of head and neck cancer. 682 47


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