Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient is reported whose ailment meets the criteria of CPM. The illness was complicated by pneumonitis, most likely of the aspiration type. Of particular interest was the reversibility of a clinical picture of marked deterioration when attention was paid to fluid and electrolyte balance and maintenance of respiration. This patient's illness appears to meet the criteria of CPM, namely impairment of the facial muscles and tongue with dysphagia and dysarthria, flaccid quadriparesis or quadriplegia, and frequently, lack of response to painful stimuli followed by respiratory paralysis. The presence of peripheral neuropathy has been previously noted in a patient with CPM, but it is not an integral part of the disease.
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PMID:Central pontine myelinolysis. 37 56

A 38-year-old man developed pain and peripheral-type weakness on the right side of his face and was discovered to have decreased hearing bilaterally, as well as optic nerve swelling on the right. The pain and optic nerve swelling subsided over a period of six weeks, but hearing loss and facial weakness persisted. Thirty months later, he developed dysphagia, ataxia, dysarthria, nystagmus, and progressive spastic quadriparesis. He died approximately four years after the onset of the illness. Although no evidence of disease was found other than in the central nervous system during life, two nodules in the right lower lung were found on autopsy. The examination of these nodules, as well as the brain stem, showed an angiocentric and angionecrotic process with lymphoreticular and plasmacytoid invasion.
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PMID:Lymphomatoid granulomatosis clinically confined to the CNS. A case report. 58 1

A 28-year-old woman developed central pontine myelinolysis (CPM) following severe hyponatremia. Radiological examinations demonstrated a characteristic pontine lesion of CPM. Her neurological symptoms (drowsiness, emotional lability, dysarthria, dysphagia, and quadriparesis) were improved dramatically by treatment with thyrotropin-releasing hormone (TRH) and rehabilitation. However, results of repeat computed tomographic (CT) scans of the brain remained unchanged. This case therefore suggests that TRH may be beneficial for the treatment of CPM, and that CT findings appear to be a limited prognostic indicator for CPM.
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PMID:Dramatic recovery from neurological deficits in a patient with central pontine myelinolysis following severe hyponatremia. 192 Sep 71

A 64-year-old hypertensive woman with hyponatremia due to acute gastroenteritis and the use of diuretics developed dysarthria, dysphagia, and quadriparesis 4 days after rapid correction of hyponatremia. The clinical course, electrodiagnosis (blink reflex) and cranial computed tomographic findings are compatible with an antemortem diagnosis of central pontine myelinolysis (CPM). CPM can be prevented by cautious correction of hyponatremia. Spontaneous recovery in this case contrasts sharply to the poor outcome in previously reported cases of CPM.
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PMID:Antemortem diagnosis of central pontine myelinolysis--report of a case. 228 70

Thirty cases of diffuse Lewy body disease (DLBD) have been reported, primarily by neuropathologists, but an associated clinical syndrome has not been clearly defined. Four recent cases have led us to examine the clinicopathologic correlations. Patients are usually elderly, with symptoms lasting from 1 to 20 years. Progressive dementia or psychosis is typically the first and most prominent feature. Parkinsonian signs, initially mild or absent, become common eventually, and rigidity is usually severe. Involuntary movements, myoclonus, quadriparesis in flexion, orthostatic hypotension, and dysphagia have also been noted. Classic, concentric Lewy bodies are found profusely in the brainstem, basal forebrain, and hypothalamic nuclei, while less well defined "Lewy-like" bodies occur in limbic structures and in deep neocortical layers. In addition, focal spongiform changes in the mesial temporal lobe were found in two of our cases. We suggest that DLBD may be another specific cause of progressive dementia.
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PMID:Diffuse Lewy body disease and progressive dementia. 284 93

Anterior stabilization with combined plate and bone fusion was performed after neural decompression on ten patients for spondylotic cervical myelopathy, and for radiculopathy or trauma in three patients. Medial corpectomy was performed at one to four levels. Iliac crest or fibular bone grafts were secured by plates anchored to the graft and adjacent vertebral bodies. All patients were placed in Minerva braces postoperatively. There was successful fusion in all cases, and no graft dislodgement or kyphosis. Early initiation of rehabilitation was achieved. Morbidity occurred in patients with severe spondylotic cervical myelopathy. This include respiratory depression requiring reintubation in 2/13 procedures, dysphagia (2/13) from loosening of the screws or prominent hardware and graft, and screw loosening (2/13). Neurological improvement was present in 85% (11/13) of patients. There was no deterioration of neurological function in any case. We conclude from this early follow-up that anterior bone fusion with supplemental plates provides effective stabilization for the unstable cervical spine. Greater morbidity risk exists in patients with severe spondylotic cervical myelopathy and spastic quadriparesis who required multilevel medial corpectomies and fusion.
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PMID:Cervical stabilization by plate and bone fusion. 338 10

A 32-year-old woman with histiocytic lymphoma was in complete clinical remission after two courses of chemotherapy, when peripheral neuropathy developed fulminantly. Abnormalities included facial nerve paralysis, dysphagia, quadriparesis, myalgia, and incontinence. She died 10 days after onset of these symptoms. Postmortem examination revealed infiltration of peripheral nerves by lymphomatous cells with no involvement of meninges, brain, lymph nodes, or other organs. Differences in the blood-brain barrier of peripheral and central nervous system are suggested: The peripheral barrier may be more penetrable by malignant histiocytes or less permeable to cytotoxic drugs. Intrathecal chemotherapeutic drug instillation and irradiation may be beneficial.
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PMID:Fatal peripheral neurolymphomatosis after remission of histiocytic lymphoma. 629 28

The distribution and manifestations of arthritic diseases vary widely between different populations and countries. Our study confirms the presence of diffuse skeletal hyperostosis (DISH) in Middle Eastern as well as western populations. The clinicoradiological pattern of 38 patients with DISH syndrome in the Middle East is described. It shows general agreement with the pattern described in western countries with regard to sex, age, most of the clinical symptomatology and radiological findings. None of our patients, however, suffered from dysphagia in contrast to a high incidence in Europe and the United States. One case of quadriparesis is reported in our series. We noted a higher association with diabetes mellitus and lower incidence of cervical, lumbar and upper extremity radiological involvement.
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PMID:Diffuse idiopathic skeletal hyperostosis (DISH). A clinicoradiological study of the disease pattern in Middle Eastern populations. 633 78

A 44-year-old man developed a clinical syndrome characterized by nonprogressive spastic quadriparesis, dysarthria, and dysphagia following a severe cervical hyperextension injury. These clinical features, coupled with normal neuroimaging studies, are consistent with a stretch injury of the corticospinal and corticobulbar tracts at the pontomedullary junction.
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PMID:Spastic quadriparesis, dysarthria, and dysphagia following cervical hyperextension: a traumatic pontomedullary syndrome. 778 27

Neurological disorders may be seen in end-stage renal disease patients due to uraemia or to complications of dialysis. A dysequilibrium syndrome may be seen, usually soon after or towards the end of haemodialysis. This group of patients has no particular findings on MRI. On the other hand, the osmotic demyelination syndrome has definitive MRI findings, not to date reported with the dysequilibrium syndrome. We report a patient with end-stage renal disease and the dysequilibrium syndrome who showed findings of osmotic demyelination on MRI. The patient had a convulsion after a first haemodialysis, with quadriparesis and hyperactive deep tendon reflexes and bilateral Babinski signs. The upper motor neurone signs lasted for a week. Meanwhile, he was also dysarthric and had dysphagia. He recovered neurologically without any residuum following appropriate treatment and there was improvement on MRI.
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PMID:Osmotic demyelination syndrome with a dysequilibrium syndrome: reversible MRI findings. 959 92


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