Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of infantile spinal muscular atrophy (Werdnig-Hoffmann's disease) with complete proximal pareses obvious at birth giving rise to neonatal asphyxia is reported. Reduction of fetal movements was noted from the 32nd week of pregnancy. The infant was extremely floppy at birth and spontaneous movements were restricted to hands, feet and face. Fibrillations of the tongue, diaphragmatic hemiparesis and dysphagia were observed. Unassisted ventilation was not compatible with survival and the infant succumbed to the disease in the neonatal period. Muscle biopsy and autopsy confirmed the clinical diagnosis. Infantile spinal muscular atrophy causing neonatal asphyxia seems to be unusual and not earlier described. Constant muscular hypotonus in an asphyctic newborn should raise suspicion of a neuromuscular disorder.
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PMID:Infantile spinal muscular atrophy (morbus Werdnig-Hoffmann) causing neonatal asphyxia. 57 32

Venous thrombosis after pacemaker implant is a known, although often underrecognized condition that can challenge system revision or upgrading, leading occasionally to thromboembolic complications. Several factors are considered to promote thrombus formation. Among them, alteration of blood flow mechanics due to the presence of catheters in the vessel lumen may itself play a pivotal role. Hereby we present the case of a 65-year old men who underwent a dual-chamber pacemaker implant in another institute for sick sinus syndrome by means of left cephalic venous access. About two months later he started experiencing neck swelling, pain and dysphagia. Six months later, ultrasonography and CT-scan revealed complete jugular vein thrombosis caused by a lead loop at the level of the left subclavian vein. Of note, thrombosis occurred despite proper oral anticoagulation with warfarin undertaken for coexisting atrial fibrillation. It's important to keep in mind this possible complication of pacemaker implant to allow for early diagnosis and better treatment chances. This case report is an example of how proximal catheter displacement may promote thrombus formation, probably by affecting blood flow mechanics, even in spite of proper oral anticoagulation.
J Atr Fibrillation
PMID:Internal Jugular Vein Complete Thrombosis After Dual Chamber Pacemaker Implant. 2790 11

In patients with advanced esophageal cancer, management of dysphagia is a challenge with significant implications on patient quality of life. Brachytherapy has been shown to be an effective and safe treatment option for symptoms related to dysphagia. The effect of endoscopic brachytherapy on patients with a cardiac implantable electronic device has not previously been described in literature. We present an 89-year-old female with a dual chamber permanent pacemaker who elected to undergo palliative brachytherapy delivered via endoscopy for treatment of dysphagia secondary to locally advanced esophageal adenocarcinoma.
J Atr Fibrillation 2019 Jun
PMID:Safe Delivery of Endoscopic Brachytherapy in a Patient with a Dual Chamber Pacemaker. 3168 64