Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 80-year-old man was admitted to the hospital with recurrent right-sided aspiration pneumonia, found on barium swallow to be due to diffuse idiopathic skeletal hyperostosis (Forrestier's disease) of the cervical spine, with the formation of a giant cervical osteophyte. He was treated conservatively with a feeding gastrostomy. The medical literature concerning this unusual cause of dysphagia and aspiration pneumonia is reviewed.
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PMID:Aspiration pneumonia secondary to giant cervical osteophyte formation (diffuse idiopathic skeletal hyperostosis or Forrestier's disease): a case report. 982 35

Intubation no longer remains the only solution to feeding problems of the elderly patient with dysphagia. Dysphagic disorders result from neurogenic, myogenic, psychogenic, or mechanical causes. Thus numerous hospitalized or institutionalized elderly patients may have dysphagic symptoms. The consequences of this disorder are significant, and aspiration pneumonia is often the outcome. Current diagnostic procedures available to identify dysphagia are discussed.
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PMID:Current procedures for diagnosing dysphagia in elderly clients. 986 10

The purpose of this investigation was to determine the overall prevalence of aspiration in dysphagic individuals referred for a modified barium swallow and the underlying anatomic and/or physiologic causes. A total of 166 patients were seen during a 1-month period at 5 participating institutions. Aspiration was detected in 51.2% of the patients. The most common causes were decreased laryngeal elevation and delayed triggering of the pharyngeal motor response. A history of aspiration pneumonia was significantly associated with the presence of aspiration on modified barium swallow study. The presence of a protective cough was present in only 53% of patients who aspirated, reinforcing the need for appropriate radiologic assessment in patients with suspected dysphagia.
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PMID:Aspiration: cause and implications. 1018 36

Making palliative care decisions for a patient who lacks decision-making capacity presents several challenges. Other people, such as family and caregivers, must choose for the patient. The goals and values of these decision makers may conflict with those of each other and with those of the patient, who now lacks the capacity to participate in the decision. This paper presents a case study of a patient with severe Alzheimer disease who has two common clinical problems: neurogenic dysphagia and aspiration pneumonia. The case study describes a consensus-based decision-making strategy that keeps what is known about the patient's wishes and values in the foreground but also expects guidance from the physician and elicits input from family members and other people who care for and have knowledge about the patient. The steps of this process, including key clinical prompts and potential transition statements, are outlined and described. The overall goal of the case commentary is to demonstrate that physicians can guide a highly emotional and personal process in a structured manner that has meaning for the patient, family, physician, and other caregivers.
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PMID:A consensus-based approach to providing palliative care to patients who lack decision-making capacity. ACP-ASIM End-of-Life Care Consensus Panel. American College of Physicians-American Society of Internal Medicine. 1036 74

As part of a larger study that investigated the social, cultural, clinical, and environmental factors that influenced nutritional intake in two proprietary nursing homes, 82 of 100 residents who were not eating well received a bedside dysphagia screening evaluation by a speech pathologist. This article reports on the dysphagia evaluation results and the consequences of swallowing disorders for nursing home residents. Forty-five of the 82 residents (55%) had some degree of dysphagia, ranging from mild to profound, but only 10 of these 45 residents (22%) had been referred for a dysphagia evaluation. Unrecognized and unmanaged dysphagia may lead to dehydration, malnutrition, aspiration pneumonia, and asphyxiation. Assessment and management of dysphagia also are discussed.
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PMID:Dysphagia among nursing home residents. 1038 21

Prognosis of 21 patients with multiple system atrophy (MSA) who deceased or received tracheostomy is described. The percentage of patients with MSA among the cases of spinocerebellar degeneration was 40% in National Tokyo Hospital. There were 12 women and 9 men, and the mean age at onset was 56 years. Seventy-four percent of MSA patients was olivopontocerebellar atrophy (OPCA), 22% was striatonigral degeneration (SND). The mean age of 17 deceased patients (10 women, and 7 men) was 65.5 years. Ten patients did not undergo tracheostomy and deceased, and 11 patients underwent tracheostomy, among whom 4 patients are still alive. Mean duration of illness from onset to death (without tracheostomy) or tracheostomy was 6.8 years. Cause of death of patients who did not undergo tracheostomy was related to paresis of the larynx or pharynx, for example, aspiration pneumonia due to dysphagia, vocal cord paralysis and sudden death. Some of those who underwent tracheostomy deceased for causes which were not directly related to MSA such as cerebral hemorrhage or uremia, but others seem to be related to some problems of respiratory center such as central chronic respiratory failure, or sudden death (sometimes it happened after infection, but the obstruction of the respiratory tract was not always present at autopsy).
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PMID:[Prognosis of multiple system atrophy--survival time with or without tracheostomy]. 1042 39

The purpose of this article is to review the ongoing clinical research on assessment of laryngeal and pharyngeal sensitivity with particular emphasis on the technique of endoscopic air pulse stimulation of the laryngopharyngeal mucosa. Studies of laryngopharyngeal sensation in healthy controls and in stroke patients with dysphagia are presented initially. What then follows is a detailed description of a study comparing modified barium swallow and pharyngolaryngeal sensory testing as predictors of aspiration pneumonia after stroke. Finally, the combination of laryngopharyngeal sensory testing with endoscopic swallowing evaluations, termed flexible endoscopic evaluation of swallowing with sensory testing, and its implications in the office or bedside evaluation of the patient with dysphagia are discussed.
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PMID:Clinical assessment of pharyngolaryngeal sensitivity. 1071 55

Swallowing disorders are common, especially in the elderly, and may cause dehydration, weight loss, aspiration pneumonia and airway obstruction. These disorders may affect the oral preparatory, oral propulsive, pharyngeal and/or esophageal phases of swallowing. Impaired swallowing, or dysphagia, may occur because of a wide variety of structural or functional conditions, including stroke, cancer, neurologic disease and gastroesophageal reflux disease. A thorough history and a careful physical examination are important in the diagnosis and treatment of swallowing disorders. The physical examination should include the neck, mouth, oropharynx and larynx, and a neurologic examination should also be performed. Supplemental studies are usually required. A videofluorographic swallowing study is particularly useful for identifying the pathophysiology of a swallowing disorder and for empirically testing therapeutic and compensatory techniques. Manometry and endoscopy may also be necessary. Disorders of oral and pharyngeal swallowing are usually amenable to rehabilitative measures, which may include dietary modification and training in specific swallowing techniques. Surgery is rarely indicated. In patients with severe disorders, it may be necessary to bypass the oral cavity and pharynx entirely and provide enteral or parenteral nutrition.
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PMID:Evaluation and treatment of swallowing impairments. 1079 85

Photodynamic therapy (PDT) was recently approved by the Food and Drug Administration for palliating obstructing esophageal cancer. This report reviews our initial experience using PDT to treat malignant dysphagia. Patients with inoperable, obstructing esophageal cancer were considered for PDT. Photofrin was injected 48 hours before endoscopic laser activation. Dysphagia score was assessed. Thirty patients underwent 53 PDT courses. Improvement in dysphagia occurred in 83%. Mean dysphagia score decreased from 2.8 to 1.8 (p < 0.05). Complications included esophageal stricture (9.4%), candida esophagitis (5.7%), symptomatic pleural effusion (5.7%), contained esophageal perforation (1.9%), aspiration pneumonia (1.9%), and sunburn (13.2%). Seventeen patients (57%) required more than one PDT treatment, and in 10 an expandable metal stent was used as an adjunct. The 30-day mortality rate was 7%. PDT is effective in palliating patients with malignant dysphagia. The ideal patient for PDT has an obstructing, primarily endoluminal esophageal tumor with minimal extrinsic compression.
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PMID:Photodynamic therapy for treatment of malignant dysphagia. 1080 93

Symptomless dysphagia and swallowing disorders play a very important role in the pathogenesis of aspiration pneumonia. A videofluoroscopic examination and a simple two-step swallowing provocation test (STS-SPT) could be useful for detection of swallowing disorders in elderly patients with stroke, however, there is no report on such a test for detection of symptomless dysphagia. We administered 1 ml Technetium Tin Colloid (99mTC) to the patient during sleep via a nasal catheter placed in the mouth. At 09:00 h the next day, symptomless dysphagia was checked for by imaging. Improvement of the symptomless dysphagia was observed, and thus we could prevent the occurrence of aspiration pneumonia. The 99mTC test was particularly useful in detecting symptomless dysphagia in elderly patients with stroke.
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PMID:Technetium tin colloid test detecting symptomless dysphagia and ACE inhibitor prevented occurrence of aspiration pneumonia. 1081 9


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