Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 68-year-old woman was seen with recent-onset dysphagia. Investigations suggested a large retrocardiac tumor. At thoracotomy, a highly vascular tumor was found, involving the posterior and left aspect of the pericardium with attachment to the heart. The lesion was partially removed, and histopathological analysis revealed a malignant hemangiopericytoma. To our knowledge, this tumor site and its presentation have not been reported before.
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PMID:Pericardial hemangiopericytoma as a cause of dysphagia. 333 85

We describe a 35-year-old man with a primary cystic mediastinal hemangiopericytoma who presented with the complaint of progressive dysphagia for 6 months. The computed tomography and magnetic resonance imaging findings revealed that a well-defined, fluid-filled mass (measuring approximately 10 x 10 cm) was located posterior to the heart and inferior to the carina of the bronchus. Tumor puncture showed translucent yellow fluid with normal concentrations of carcinoembryonic antigen, squamous cell carcinoma-related antigen, and carbohydrate antigen 19-9 and a high concentration of carbohydrate antigen 125. After removal of the tumor, microscopic examination revealed a malignant hemangiopericytoma. To our knowledge, this is the first case of a primary mediastinal hemangiopericytoma with cystic formation. Moreover, we showed the specific biochemical findings of the cystic fluid that were useful for differentiation from other cystic mediastinal tumors.
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PMID:A case of primary cystic mediastinal hemangiopericytoma. 819 68

Hemangiopericytoma (HPC) is a rare tumor of uncertain malignant potential arising from mesenchymal cells with pericytic differentiation. It accounts for 3-5% of soft tissue sarcomas and 1% of vascular tumors. It usually presents in 5th to 6th decade of life. Most common sites are limbs, pelvis and head and neck. About 20% of all hemangiopericytomas are seen in head and neck, mostly in adults. Usually it presents in orbit, nasal cavity, oral cavity, jaw, parotid gland, parapharyngeal space, masticator space and jugular foramen. Long term follow up is important because of imprecise nature of the histological criteria for prediction of biologic behavior.We report herein a case of HPC in 66-year-old man, who presented in our department with headache, nasal obstruction and dysphagia. A neck computer tomography scan and magnetic resonance imaging showed a large left parapharyngeal mass bulging into nasopharynx and oropharynx with extension to pharyngeal mucosal surface and causing narrowing of airways and total obstruction of left posterior nostril. Angiography showed a highly vascular neoplasm. Initially he was managed as a case of schwannoma and embolization was done but with no response. An attempt to do complete surgical resection was made, but due to its critical position, it was not possible. During surgery, highly vascularised tumor was found. The histopathologic examination revealed a vascular tumor consistent with hemangiopericytoma G-II. The patient had normal postoperative course of healing and was given adjuvant radiation. He is on regular follow up without signs of recurrence or metastases.In summary, parapharyngeal space is a rare site of presentation for hemangiopericytoma which is highly vascular tumor, requiring extensive work up including magnetic resonance imaging, computed tomography scan and angiography. Complete surgical excision should be attempted. Postoperative radiation is indicated in cases of incomplete resection.
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PMID:Parapharyngeal space hemangiopericytoma treated with surgery and postoperative radiation--a case report. 2449 30