Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of malignant mesothelioma (MM) in a 15 year old boy is reported. He had a prosthetic aortic valve implanted in 1980 at our centre for rheumatic aortic regurgitation. Fever, weight loss and chest pain as initial symptoms suggested possibility of prosthetic valve endocarditis. Dysphagia as another initial symptom was interesting and caused further diagnostic dilemma. Role of Computerised Tomography (CT) scan in diagnosis of MM is highlighted.
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PMID:Malignant mesothelioma in the young (with prosthetic aortic valve an unusual association). 280 92

Dysphagia and retrosternal pain are common complaints in patients after cardiac operations, and most often they result from the median sternotomy and/or endotracheal intubation. Although Candida esophagitis is a recognized cause of similar symptoms, it is usually not suspected except in immunologically compromised hosts. This report describes the case histories of five patients, not immunosuppressed or cachectic, who developed persistent dysphagia during recovery from cardiac operations; four patients received only 4 days of preoperative and postoperative prophylactic antibiotic treatment with cefazolin (Kefzol) and cephalexin (Keflex). A nasogastric tube had been used for less than 24 hours in the postoperative period. The fifth patient developed symptoms following prolonged and varied antibiotic therapy. Candida esophagitis was diagnosed by a combination of coexisting oral candidiasis (5/5), roentgenographic appearance on barium swallow (5/5), endoscopy (4/4), and biopsy or culture (2/4). Initial therapy consisted of antireflux measures and antacids (4/5), cimetidine (4/5), oral nystatin in methylcellulose base (1,000,000 units every 4 hours) (4/5), and termination of other antibiotic therapy (1/5). These measures were effective in clearing the infection in only two patients. A third patient required prolonged massive oral nystatin therapy, and in two patients intravenous Amphotericin B was necessary to control infection. Two patients subsequently developed strictures which necessitated multiple esophageal dilatations. One of these patients developed endocarditis during home dilatation therapy. All patients are currently free of disease. Current measures utilized to recognize and treat the disease are discussed.
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PMID:Candida esophagitis following cardiac operation and short-term antibiotic prophylaxis. 743 63

To describe the role of transesophageal echocardiography (TEE) in the diagnosis of various cardiac pathologic conditions, we reviewed the currently accepted clinical applications, the contraindications to the procedure, and the potential complications. The Mayo Clinic experience with 7,134 TEE examinations during a 6-year period (1988 through 1993) was summarized, and TEE results reported in the literature were reviewed. TEE has a substantially higher yield than transthoracic echocardiography (TTE) for diagnosis of direct and indirect sources of cardioembolism. Moreover, TEE is highly sensitive for detecting abnormalities of mitral prostheses and endocarditis-related complications of aortic prostheses. TEE is superior to TTE for localization and characterization of cardiac and paracardiac masses. In addition to establishing the diagnosis of aortic dissection, TEE can readily show the site, type, and extent of the tear. Ventilated, critically ill patients can safely undergo TEE. TEE has a limited role in the assessment of neonates, infants, and children with congenital heart disease because TTE can provide almost all the necessary information in such patients. Intraoperatively, TEE is useful for managing patients undergoing mitral valve repair and for monitoring for air and fat embolism in those undergoing neurosurgical procedures or hip replacement. Absolute contraindications to the performance of TEE include a history of dysphagia, current pathologic conditions of the esophagus, and recent esophageal operations. In patients with relative contraindications, such as esophageal varices or active upper gastrointestinal bleeding, the risk-to-benefit ratio must be assessed before TEE is performed. Complications associated with TEE can be related to the probe, to the procedure, or to drugs used during the examination.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Transesophageal echocardiography. 780 45

Post-tonsillectomy bacteremia is a well-recognized aetiological factor in streptococcal endocarditis, and prophylactic penicillin has been recommended to reduce its incidence in susceptible patients undergoing tonsillectomy. Recent studies have shown a change in the microflora and an increase in the number of penicillin-resistant organisms in the tonsils of patients undergoing tonsillectomy. The aim of this study was to assess the incidence of post-tonsillectomy bacteraemia, to identify the micro-organisms associated with it and to review the suitability of penicillin in prophylactic regimens. The relationship between positive blood cultures and several clinical parameters such as fever, vomiting, pharyngeal discomfort, or dysphagia was also analysed. Of the 102 patients included in the study, 41 (40.1%) had positive post-tonsillectomy blood cultures. Haemophilus influenzae were isolated from 23 (56%) of the positive cultures and Streptococcus viridans in 15 (36.5%). Twenty-five per cent of H. influenzae produced beta-lactamase and only 30% of streptococci of the viridans group were penicillin-sensitive. Positivity of the blood cultures was not related to fever, discomfort, surgical technique, type of tonsil, or any of the parameters studied. Bacteraemia seems to be related to traction of the tonsil before dissection rather than direct spread of bacteria into the opened vessels. Using a beta-lactamase stable antibiotic instead of penicillin for prophylaxis would be more appropriate.
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PMID:Bacteraemia during tonsillectomy: a study of the factors involved and clinical implications. 956 68

We report a case of a 79-y-old male with enterococcal endocarditis presenting with dysphagia and weight loss. The patient's longstanding underlying bacteremia was thought to have caused pro-inflammatory changes leading to alterations in the neuronal environment affecting peripheral nerve function. Dysphagia improved once antibiotic treatment was initiated.
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PMID:Dysphagia as an unusual presentation of infective endocarditis. 1746 72

Staphylococcus aureus bacteremia is a frequent occurrence in patients with indwelling catheters. Endocarditis, osteomyelitis, and septic arthritis are common metastatic complications. A hemodialysis patient developed fever, headache, neck pain, sore throat, and dysphagia in the setting of S. aureus bacteremia. Contrast computed tomography scan of the neck revealed a retropharyngeal phlegmon. Recurrent bacteremia led to the identification of the access graft as the infectious source. We present this case to increase awareness among emergency physicians that retropharyngeal infection by S. aureus can arise by hematogenous spread and should be considered in the differential diagnosis of a bacteremic patient with sore throat or neck pain.
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PMID:Retropharyngeal phlegmon in a hemodialysis patient with Staphylococcus aureus bacteremia. 1829 11