Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The syndrome of acute bilateral basal ganglia lesions presents with parkinsonism, altered mental status, dysarthria, and dysphagia in association with specific imaging findings in the basal ganglia. It is an uncommon syndrome seen almost exclusively in patients with diabetes mellitus and renal failure. Previously reported cases have all run a monophasic course, but we report a patient with a relapsing, remitting course. This 64-year-old diabetic man with uremia on hemodialysis had an acute episode of disordered sensorium. Brain computed tomography showed the classic findings of hypointensity of bilateral basal ganglia. He recovered from the episode, but had another with parkinsonian symptoms about 18 months later. Sequential brain images demonstrated encephalomalacia of the basal ganglia. His condition waxed and waned several times, but he eventually died of unknown causes less than 2 years after the first event. This syndrome, therefore, may not be limited to just one episode.
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PMID:The syndrome of bilateral basal ganglia lesions in diabetic uremic patients presenting with a relapsing and remitting course: a case report. 1822 16

We present a 9-year-old boy with history of perinatal asphyxia and neonatal seizures; who presented with delayed development of speech, with predominant dysarthria, dysphagia, and drooling of saliva and unable to protrude tongue along with delayed motor and mental milestones. He had complex partial seizures since last 3 years requiring multiple anti-epileptic drugs. He had dysarthria, nasal twang, and drooling of saliva with difficulty in chewing and swallowing. Hearing and understanding were normal. Bilateral trigemino-facio-linguo-pharyngeal palsy was noticed on voluntary movements with normal jaw jerk with preserved automatic and emotional motor movements. Electroencephalography revealed focal left fronto-temporal epileptiform discharges and brain imaging was suggestive of bilateral cortical and subcortical region encephalomalacia, predominantly involving bilateral opercular region. The clinical and neuroimaging features correspond to bilateral opercular syndrome which could have resulted from the perinatal insult in this case.
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PMID:Opercular syndrome: A case report and review. 2408 30