Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011168 (dysphagia)
 15,644 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A series of 23 patients with suspected recurrent disease following 'curative' resection for gastric carcinoma was submitted to further laparotomy (24 operations). Three patients were found to have hopeless dissemination, 10 had palliative procedures performed which relieved their dysphagia, vomiting and jaundice, 4 had recurrences resected and 1 had a second primary of the gastric stump excised. No less than 6 were found to have benign lesions. Although the reward as far as prolonged survival is small, we believe that the relief of symptoms and the occasional long term excellent result justifies judicious use of a 'second look' laparotomy for suspected recurrent disease.
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PMID:Is 'second look surgery' justified in suspected recurrences of cancer of the stomach? 4 53

Fibreoptic-endoscopic dilatation and intubation is a relatively new and safe palliative treatment for patients with inoperable esophageal carcinoma. The procedure is described at length in three patients in whom it produced instant relief of dysphagia and rapid improvement of nutrition. The stay in hospital is reduced to a minimum. Possible complications are discussed.
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PMID:[The fiberoptic-endocopic intubation for the palliatuve treatment of malignant esophageal stenosis]. 8 22

We retrospectively reviewed our experience with palliative dilation for dysphagia in esophageal carcinoma. During a 3-year period 26 patients with squamous-cell carcinoma of the esophagus underwent peroral esophageal dilation for relief of dysphagia. Twenty-four were able to resume a soft or regular diet after dilation. This improvement was accomplished with low morbidity and no mortality. Dilations were done without additional risk in patients with malignant tracheoesophageal fistulae and in patients undergoing radiation therapy. We conclude that esophageal dilation can be done safely and effectively in patients with squamous-cell carcinoma of the esophagus. Palliative dilation can significantly improve the quality of life for these patients and should be considered an important part of their management plan.
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PMID:Palliative dilation for dysphagia in esophageal carcinoma. 8 17

Malignant tumours of the oesophagus cannot always be handled radically; in personal clinical experience, only a third of patients suffering from oesophageal carcinoma have been subjected to radical oesophagectomy. The purpose of palliative treatment is to suppress dysphagia and restore possibly natural, adequate feeding. As for techniques, intraluminal catheterization by the combined endoscopic and gastrotomic route has been personally preferred to surgical bypass and gastrostomy whose palliative value should be confined to cases in which no other technique can be used. Good results have been obtained with catheterization and patients have been able to feed themselves naturally without noting the ineluctability of their disease.
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PMID:[Palliative treatment of esophageal carcinoma. Personal surgical experience]. 9 Mar 48

Peroral pulsion intubation for the palliation of dysphagia due to oesophageal carcinoma was performed on 652 patients. The mortality was 16%, failure rate 3%, and hospital stay 3 days. Advanced disease and the presence of oesophagorespiratory fistula is not a contraindication to intubation.
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PMID:Palliative pulsion intubation in oesophageal carcinoma. 9 Apr 75

Zenker's diverticulum is a common developmental anomaly seen usually in the elderly. Carcinoma in this pharyngoesophageal outpouching has been reported in only 23 instances. A 55-year-old woman is presented whose only symptoms were dysphagia and periodic regurgitation of bloodstained material. Barium swallow and esophagoscopy confirmed the presence of a neoplasm, and biopsy revealed an epidermoid carcinoma. Wide field resection was followed by a full course of irradiation and secondary pharyngoesophageal reconstruction. The patient was free of disease at three-year follow-up.
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PMID:Carcinoma in a Zenker's diverticulum. 12 79

Neoplasms of the nasopharynx are rare in children, but they threaten the child's life when they do occur. The nasopharynx tends to harbor dysontogenetic neoplasms. After classification into benign and malignant groups, nasopharyngeal neoplasms in children can be further characterized according to the age of the patients in which the clinical manifestations usually appear. Dermoids and teratomas are the most frequently encountered neoplasms of the nasopharynx in infants and may produce airway obstruction and dysphagia. Among the benign tumors of the nasopharynx in children, the juvenile angiofibroma deserves the most attention. With the onset in puberty, these neoplasms may cause recurrent massive bleeding and orbital and intracranial complications. Evaluation of the extent of the neoplasm and the source of the blood supply has been improved with bilateral selective internal and external carotid angiography. Intracranial and orbital invasion is regarded as an indication for radiotherapy. Surgery has been made somewhat safer by preoperative estrogen therapy and angiographic embolization of the major arterial supply. Patients with squamous cell carcinoma of the nasopharynx have immunologic similarities to patients with Burkitt's lymphomia and infectious mononucleosis; The etiologic role of the Epstein-Barr virus is considered. The parts played by radiation therapy, surgery, chemotherapy, and cryosurgery in the treatment of children with carcinoma of the nasopharynx are discussed. The value of radical neck dissection after radiation therapy is critically reviewed. The prognosis in patients with carcinoma of the nasopharynx is better in females than in males and better in children than in adults.
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PMID:Neoplasms of the nasopharynx in children. 19 80

Dysphagia due to secondary involvement of the oesophagus by pancreatic carcinoma is relatively rare. Occasionally, the oesophagus may be involved by direct extension of a carcinoma of the body and/or tail of the pancreas or metastatic lymphadenopathy in the posterior mediastinum. Although the literature contains a few case reports in which barium studies revealed displacement or obstruction of the distal oesophagus, a benign-appearing, smooth, tapered narrowing of the distal oesophagus with a fixed, right-angled configuration is a radiological finding which has not been previously emphasised. In the author's experience, this abnormality may be a helpful radiological clue to the diagnosis of carcinoma of the tail of the pancreas. The clinical, radiological and pathological findings in four patients with dysphagia and a right-angled narrowing of the distal oesophagus secondary to carcinoma of the tail of the pancreas are described and illustrated; the radiological differential diagnosis is briefly discussed.
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PMID:Right-angled narrowing of the distal oesophagus secondary to carcinoma of the tail of the pancreas. 42 21

Esophageal neoplasms were diagnosed in 8 of 49,229 dogs seen over the last 11 years at the Veterinary Medical Teaching Hospital of the University of California at Davis. The neoplasms were primary in 2 dogs and metastatic to the esophagus in 6 dogs, with thyroid carcinoma being the most common site of the primary tumor. The most common clinical signs were regurgitation, dysphagia, weight loss, development of neck masses, and respiratory difficulties. It was concluded that the clinical signs often can be misleading. The interpretation of survey radiographs, barium contrast studies, or fluoroscopic studies often provide the initial data base. The final diagnosis requires histologic examination. Retention of air in the esophagus (with or without esophageal displacement) and motor dysfunction (with or without gross morphologic changes) are the most important criteria for radiographic diagnosis.
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PMID:Clinical and radiographic signs in primary and metastatic esophageal neoplasms of the dog. 42 31

The first symptoms of cancer of the oesophagus in 82 Xhosa patients were found to be dysphagia (43%), interscapular back pain (23%), sore throat (21%) and epigastric pain (11%). More than half of the patients in whom a sore throat was the first symptom of the disease described the simultaneous occurrence of oropharyngeal lesions (amaqhakuva). No correlation could be found between the first symptoms and the characteristics of the oesophageal carcinoma at the time of presentation.
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PMID:The first symptoms of carcinoma of the oesophagus, with particular reference to amaqhakuva. A report from the Republic of Transkei. 46 28


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