Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011053 (deafness)
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Human Gene/Protein
PAHX-AP 11.6
chromosome 2 open reading frame 37 11.6
MYO3A protein 11.6
deafness locus associated putative guanine nucleotide exchange factor 11.6
Succinate-CoA ligase, ADP-forming, beta subunit 11.6
DELGEF 11.6
PDZ domain containing 7 11.6
TMEM2 protein 11.6
COIII protein 11.6
COL11A2 protein 11.6
ZFOC1 11.6
protein phosphatase 2A regulatory subunit A beta isoform 11.6
ADRACALIN 11.6
DFNB8 11.5
LRTOMT 11.4
DFNB9 11.3
DFNB3 11.2
CMTX5 11.1
Melnick-Fraser syndrome 11.0
WS2A 11.0
DFNB31 11.0
MYO15A 11.0
DFNA3 11.0
TMIE 10.9
DFNB23 10.9
Stereocilin 10.9
ELMOD3 10.9
TMPRSS3 10.8
mucolipin 3 10.8
TMC1 10.7
USH1F 10.7
OTOF 10.6
PXMP3 10.6
myosin-IXa 10.6
SERAC1 protein 10.6
SCD5 protein 10.6
TMEM164 10.6
PDZD7 10.6
CLRN2 10.6
AMPA 3 10.6
CIB2 protein 10.6
Transmembrane channel-like protein 1 10.6
DFNB63 10.6
LHFPL5 10.6
CDH23 protein 10.6
Doublecortin domain-containing protein 2 10.6
DFNB36 10.6
DMXL2 protein 10.6
COCH protein 10.6
Otoancorin 10.6
PTPRQ 10.6
POU3F4 10.5
stereocilin 10.5
GJB2 10.4
otospiralin 10.4
MYO7A 10.4
otoferlin 10.4
protocadherin 15 10.4
DFNA10 10.4
OTOA 10.4
gap junction protein beta 2 10.4
TMC2 10.4
lipoma HMGIC fusion partner-like 5 10.3
cadherin-23 10.3
pejvakin 10.3
TMC1 protein 10.3
DFNB22 10.3
deafness dystonia protein 1 10.3
DFNB59 10.3
USH1B 10.3
CDH23 10.3
PCDH15 10.3
SLC26A4 10.2
GIPC3 10.2
ILDR1 10.2
ATP6B1 10.2
transmembrane protease, serine 3 10.2
barttin 10.2
USH1C 10.2
SLC19A2 10.1
more...
Disease
AUNA1 11.6
DFNB40 11.6
WS2-OA 11.6
Vestibular nerve disorder 11.6
DFNB20 11.6
DFNA16 11.6
Acquired Deafness 11.6
Cortical deafness 11.6
eustachian tube catarrh 11.6
Cranial nerve compression 11.6
Central deafness 11.6
Syndromal deafness 11.6
DFNA18 11.6
Congenital dysphasia 11.6
DFNB46 11.6
DFNB51 11.6
Neonatal hearing loss 11.6
unilateral partial deafness 11.6
Apallic syndrome 11.6
DFNB5 11.6
Cerebellopontine angle meningioma 11.6
Neonatal conjugated hyperbilirubinemia 11.6
ATS-DL 11.6
deafness 11.6
CSNB2A 11.6
AUNX1 11.6
DFNB26 11.6
X-linked recessive agammaglobulinemia 11.6
DFNB27 11.6
4p minus syndrome 11.6
CORD9 11.6
DFNB10 11.6
Circumscribed labyrinthitis 11.6
DFNB65 11.6
CMTX4 11.6
DFNB15 11.6
NPHP1, DEL 11.6
Deafness 11.5
DFNB18 11.5
DFNB8 11.5
Thiamine-responsive megaloblastic anemia 11.4
DFN2 11.4
DFNB6 11.4
DFNB48 11.4
DFNB21 11.4
DFNB23 11.3
DFNB3 11.3
CMTX5 11.3
DFNB9 11.2
DFNA25 11.2
Tropical ataxic neuropathy 11.2
DFNB33 11.2
DFNB13 11.2
DFN6 11.2
DFNA48 11.2
DFNB42 11.1
DFN3 11.1
DFNB49 11.1
DFNA3 11.1
DFNB2 11.0
DFNB39 11.0
DFNB12 11.0
DFNB32 11.0
DFNA44 11.0
DFNB31 11.0
DFNB7 11.0
KID syndrome 10.9
Bart-Pumphrey syndrome 10.9
DFNB1 10.9
DFNA36 10.9
Ohdo blepharophimosis syndrome 10.9
DFNB28 10.9
DFNB30 10.9
DFNA17 10.8
BSND 10.7
DFNA22 10.7
DFNB16 10.7
DFNB4 10.7
USH1F 10.7
USH1D 10.6
more...
Symptom
Sudden deafness 11.2
Hearing complaints 10.0
Bruns nystagmus 9.6
dysacusis 8.6
diminished hearing 8.5
unable to hear 8.3
Tandem gait 8.3
Subjective tinnitus 8.1
External ophthalmoplegia 7.8
Noise-induced hearing loss 7.4
tinnitus 7.4
Circling 7.2
vertigo 7.1
dyslalia 7.1
parosmia 7.0
delayed language development 6.8
sinus pain 6.7
hyperacusis 6.7
Spontaneous nystagmus 6.6
otalgia 6.6
staggering gait 6.5
catarrh 6.3
aprosodia 6.2
cerebellar ataxia 6.2
athetosis 6.1
anosmia 6.1
loss of equilibrium 6.1
Kernig's sign 6.0
koilonychia 6.0
ophthalmoplegia 5.9
Beau's lines 5.9
loss of taste 5.9
monoplegia 5.8
pressure in the ear 5.8
General symptoms 5.7
ataxia 5.7
ENT 5.6
facial droop 5.6
Bell's phenomenon 5.6
painful swallowing 5.6
renal pain 5.5
disturbed balance 5.4
ataxic gait 5.3
abiotrophy 5.3
Deafferentation 5.2
scaly skin 5.2
hypotonia 5.1
gumma 5.1
pachyonychia 5.1
dysarthria 5.1
hearing voices 4.9
abnormal gait 4.9
dizziness 4.9
Visual symptoms 4.8
loss of balance 4.8
Visual disturbances 4.8
dystonia 4.8
photophobia 4.7
paresis 4.6
periorbital edema 4.6
auditory hallucination 4.6
vestibulitis 4.6
visual hallucination 4.4
neck stiffness 4.4
startle reaction 4.3
voice change 4.3
hepatosplenomegaly 4.3
polyuria 4.3
meningism 4.2
syncopal episodes 4.2
throat irritation 4.2
intention tremor 4.1
hypalgesia 4.1
Flare 4.1
peri-menopausal 4.1
arm weakness 4.1
Neurologic symptoms 4.1
giddiness 3.9
giddiness 3.9
bone pain 3.9
more...
Drug
Serc 10.0
Kanamycin sulfate 8.8
Dolobid 8.8
Kallidinogenase 8.1
Alsterpaullone 8.0
Mecobalamin 7.9
Meclomen 7.0
Isoxicam 6.6
Meclomen 6.6
Tirapazamine 6.1
Zinc acetate 6.0
Calcium gluconate 6.0
Benzofuran 6.0
Zmax 5.9
LVFX 5.7
Fenoprofen 5.7
PAPM/BP 5.7
Batroxobin 5.6
Naprosyn 5.4
Naftidrofuryl 5.4
Trental 5.3
Hakka 5.3
ENT 4.9
Mectizan 4.9
Salicylate 4.8
Cinnarizine 4.8
Idebenone 4.7
Acitretin 4.4
Lead acetate 4.3
Beta-2 4.2
AVC 4.1
Deferasirox 4.0
Fansidar 3.7
Azithromycin 3.7
Fansidar 3.6
Anakinra 3.6
Magnesium sulfate 3.6
Mezlocillin 3.5
DBS 3.4
IPD 3.4
NovoSeven 3.3
Piracetam 3.2
Vorinostat 3.1
Gelfoam 3.1
Riboflavin 3.0
Liraglutide 2.8
Norplant 2.8
Methylprednisolone 2.8
OMP 2.7
Papaverine 2.7
DDAVP 2.7
DDAVP 2.7
Thyroglobulin 2.6
Dihydro 2.6
CSF 2.6
Fluorescein 2.5
Clofibrate 2.5
Tuberculin 2.4
Dasatinib 2.4
Helium 2.3
Glide 2.3
Arsenic trioxide 2.3
Kainic acid 2.3
Camp 2.1
Fluorescein 2.0
Zoledronic acid 2.0
Award 1.8
ampicillin 1.8
APD 1.8
Adenosine triphosphate 1.8
Ringer's solution 1.7
Prednisone 1.6
Luteinizing 1.6
EPI 1.6
Dakar 1.5
Vitamin E 1.5
MDS 1.5
DMAP 1.5
Kenyan 1.4
RFP 1.4
more...
Enzyme
nucleotide 3'-pyrophosphokinase 8.1
HDR 7.6
proteasome ATPase 7.6
thiamine pyrophosphokinase 7.3
dihydroxyacetone phosphate acyltransferase 6.8
2-oxoglutarate decarboxylase 6.7
spermine synthase 6.4
Lod 6.3
chondroitin 6-sulfotransferase 6.2
chondroitin synthase 6.2
ornithine cyclodeaminase 6.2
dihydroxyacetone-phosphate acyltransferase 6.0
GM3 synthase 5.9
biotinidase 5.8
PRPP synthetase 5.7
calpain 10 5.6
lysyl-tRNA synthetase 5.5
factor C 5.1
seryl-tRNA synthetase 4.9
ceramide kinase 4.8
spermidine synthase 4.8
GalNAc-T 4.8
alpha-methylacyl-CoA racemase 4.8
CYP7B1 4.6
tRNase Z 4.6
guanidinoacetate methyltransferase 4.5
CTD kinase 4.5
hepsin 4.4
hepsin 4.4
jararhagin 4.3
phenylalanyl-tRNA synthetase 4.1
adenylosuccinate lyase 4.0
PTA 4.0
histidyl-tRNA synthetase 4.0
succinyl-CoA synthetase 3.9
amylomaltase 3.9
pyridoxal kinase 3.8
NPL 3.8
methylthioadenosine phosphorylase 3.7
histidase 3.7
phosphomannomutase 3.7
spermidine/spermine N1-acetyltransferase 3.6
fatty acid elongase 3.6
RNase P 3.5
leucyl-tRNA synthetase 3.4
VOR 3.3
ACC oxidase 3.2
propionyl-CoA carboxylase 3.2
alpha-galactosidase 3.2
Omi/HtrA2 3.2
propionyl-CoA carboxylase 3.2
oxidosqualene cyclase 3.1
glycerol kinase 3.1
PME 3.1
mevalonate kinase 3.0
ACC synthase 2.9
HCS 2.9
STR 2.8
complex I 2.7
mannanase 2.7
glucokinase 2.7
alpha-mannosidase 2.6
SCS 2.6
TRS 2.6
thyroid peroxidase 2.6
CDH 2.4
MTD 2.4
arylsulfatase A 2.3
PAM 2.3
branching enzyme 2.3
transketolase 2.3
3-hydroxyacyl-CoA dehydrogenase 2.2
glucocerebrosidase 2.1
alanine aminopeptidase 2.1
alpha-L-fucosidase 2.1
sphingosine kinase 2.1
tyrosinase 2.0
sialyltransferase 2.0
AGT 2.0
sialyltransferase 2.0
more...
Compound
(2-aminophenyl)methanol 11.6
1-alkenyl-2-acyl-glycerophosphoethanolamine 10.6
C7H9NO 9.6
BAHA 8.8
Chloramphenicol sodium succinate 8.6
Kanamycin sulfate 8.6
Complamin 8.6
2-butenenitrile 8.5
A 435 8.4
bromic acid 8.0
Linopirdine 7.9
3-butenenitrile 7.7
Meclofenamate sodium 7.6
Praxilene 7.6
Streptomycin sulfate 7.4
Ronicol 7.3
reduced riboflavin 7.0
Ronicol 7.0
Tiludronate 6.7
Centrophenoxine 6.5
Betahistine 6.4
Ajmalicine 6.3
Methylxanthine 6.2
Papaverine hydrochloride 6.2
Salicin 6.2
Salicin 6.2
Closantel 5.9
Fenoprofen 5.9
Zinc acetate 5.8
heme O 5.6
Thiamine 5.4
Halofantrine 5.4
HEI 5.4
Azoxymethane 5.2
Methylcobalamin 5.2
TETA 5.2
SSD 5.2
ENU 5.2
1,2,4-benzotriazine 5.0
Tanakan 4.9
Tauroursodeoxycholic acid 4.9
Scopoletin 4.9
Ginkgolide B 4.9
Diatrizoate 4.9
Diatrizoate 4.8
Retigabine 4.6
TMC 4.6
MCNU 4.6
2-chlorobenzoate 4.6
Coenzyme Q10 4.6
Spiramycin 4.5
Puerarin 4.5
coenzyme Q10 4.5
C 10 4.4
Kanamycin 4.4
C 10 4.4
Florid 4.4
Spiramycin 4.4
Diflunisal 4.4
decarboxylated S-adenosylmethionine 4.3
Practolol 4.3
DIT 4.2
DHI 4.2
Etretinate 4.2
MNE 4.2
3-hydroxyisovaleric acid 4.2
Glycyrrhetinic acid 4.2
1-benzofuran 4.1
C56 4.1
Gb4 4.0
Glycerol-3-phosphate 3.9
P2A 3.9
MGA 3.9
Amytal 3.9
Glycyrrhetinic acid 3.9
TMPD 3.9
Lawson 3.8
Ethacrynic acid 3.8
MAOA 3.8
Streptomycin 3.7
more...