Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010346 (Crohn's disease)
 21,615 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It is hypothesized that chronic gastritis and ulcerative colitis both are induced by viral infection, and that such chronic infection of the mucosa may lead to ulceration and occasionally cancer. Duodenal ulcer disease and Crohn's disease may on the other hand, be due to activation of latent viral infection of the corresponding neural ganglions, with subsequent migration of virus along the nerves to the gut wall. The gastric acid hypersecretion often occurring in patients with duodenal ulcer disease might be a consequence of viral interference with the efferent nerve function of vagal ganglions. Correspondingly, non-ulcer dyspepsia as well as irritable colon may reflect viral infection of afferent nerve function leading to pain and discomfort.
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PMID:Gastritis, peptic ulcer disease, inflammatory bowel disease, and stomach and colon cancers- are they all caused by viral infections? 732 19

39 patients with Crohn's disease underwent laparoscopic bowel resections during January 1993 to May 1995 (16 female, 23 male, with an average age of 33 years). The duration of the disease ranged from one to 18 years. 21 of the 39 patients were under steroid therapy at the time of operation. Seven patients have had ileocaecal resection for Crohn's disease. The operative technique is laparoscopically assisted. We performed: small bowel resections (8), ileocaecal resections (16), hemicolectomies (11), subtotal colectomies (2), colectomies (2). Operative time ranged from 90 to 280 min for ileocaecal resections and from 330 to 420 min for colectomies. Intraoperative complications were not encountered. Postoperatively one patient developed a subhepatic abscess which was drained under sonographic guidance on day 6. One patient was reoperated for a different disease on postoperative day 2. Two patients had fever till day 9 and 13 without clinical relevance. Two patients had delayed incision site healing. Postoperative clinical stay was 11 days. The main benefit for the patients was early mobilisation due to reduced pain. Patients experienced the small abdominal incision as a ray of hope in their chronic disease.
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PMID:[Laparoscopic resections in Crohn disease]. 899 81

Due to controversial evaluation of the contribution of clinical signs for the diagnosing of non-specific inflammatory bowel disease, as well as due to the lack of similar data, we tried to find our own answer to the question as to whether the clinical signs of ulcerative colitis (UC) and Crohn's disease (MC) are helpful, unhelpful, or even confusing for the diagnosis. A group of patients with MC and UC was analyzed from this aspect. Individuals in their twenties and thirties prevailed in the sample, mostly intellectual workers, the number of males and females was equal. Our attempt to analyze all the available diagnostic methods originated in an observation that a long period of health problems precedes the diagnosis of MC, namely 1.5 y in males and as long as 4 y in females. Other striking information was that surgery represented the initial treatment in 66% of cases and the correct diagnosis was made peroperatively only in 56% of cases. We compared our results with those of the OMGE study, one of the largest projects which evaluated positively the contribution of clinical signs to the diagnosing of MC and UC. We found that the main signs of CU have not changed in the last century, and some additional signs occur rather due to complications than due to the disease per se. Frequency of pain increased by 25% in our patients, and approximately 1/3 of it represented intermittent pain caused by tenesms. Pain in MC must be properly analyzed in order to discriminate acute appendicitis. Other indicators did not differ from the OMGE study. In accordance with its results, we confirmed the importance of correct evaluation of clinical signs for the diagnosis and differential diagnosis of UC and MC. The number of diagnostic methods still increases. Their validity must be continuously re-evaluated, however the clinical examination in the dynamic process stays to be of crucial value.
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PMID:[What is the value of clinical symptoms in the diagnosis of nonspecific inflammatory bowel disease?]. 763 12

The multicenter study with the research criteria in the field of psychotherapy/psychosomatic medicine considered nine cases. One patient with cardiac neurosis (F45.3) and one patient with a persistent somatoform pain disorder (F54.4) were diagnosed in category F45.x. The rater agreement was 63-68%. 54% of the correct diagnoses made for three cases of colitis ulcerosa and Crohn's disease concurred (28%, 50%, and 80%). The case of anorexia nervosa (F50.0) was coded correctly by all of the raters, while the agreement for bulimia (F50.2) was 82%. Only 50% of the raters correctly assigned the dissociative disorder (F44.4). The agreement achieved for factitious disorder (F68.1) was 54%. Across all the psychosomatic disorders in ICD-10 there was an agreement of 65%. This result is markedly lower than the overall agreement of the Research Criteria Study (78%). Cardiac neurosis and bulimia were given a favorable prognosis. A more reticent psychotherapeutic commitment was seen for the classical psychosomatic disorders, persistent pain disorder, and factitious disorder. Anorexia nervosa and dissociative disorder assumed an intermediate position.
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PMID:Concepts of psychosomatic disorders in ICD-10: results of the Research Criteria Study. 776 55

A case of acute relapsing pancreatitis revealing Crohn's disease is reported. The diagnosis of chronic pancreatitis was highly suspected because of characteristic pain, repeated serum pancreatic enzyme elevation and ultrasound, CT-scan, pancreatography, and endosonography data. None of the classical aetiologies for chronic or acute pancreatitis were found. This observation presents some outstanding particularities: a) pancreatitis revealed Crohn's disease; b) there was no duodenal involvement by Crohn's disease; c) the diagnosis of chronic pancreatitis was highly suspected; d) corticoids induced dramatic improvement of intestinal and pancreatic manifestations, and the patient remained asymptomatic during a two-year follow-up. The efficacy of corticotherapy on pancreatic disorders suggests a common mechanism explaining the two diseases.
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PMID:[Acute relapsing pancreatitis, revealing Crohn disease, and regressing under corticotherapy]. 787 99

A 19 year old man with a history of Crohn's disease treated with azathioprine and prednisone, died after a primary infection with Epstein-Barr virus. He had the characteristics of the virus associated haemophagocytic syndrome, a rare complication of viral infections, which consists of fever, constitutional symptoms, hepatosplenomegaly, liver function and coagulation abnormalities, and hypertriglyceridaemia. Additionally, there was pain, cytopenia, and histiocytic hyperplasia in the bone marrow, spleen, or lymph nodes. This severe complication has been reported previously in renal transplant patients, but not in those with inflammatory bowel disease taking azathioprine. The immunosuppressive therapy may have contributed to this fatal complication of infectious mononucleosis, and this complication should be considered when treating a patient with inflammatory bowel disease with azathioprine.
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PMID:Fatal infectious mononucleosis: a severe complication in the treatment of Crohn's disease with azathioprine. 788 36

Between March 1990 and August 1993, eleven stenoses were dilated to a diameter of 25 mm by balloon catheter introduced through a coloscope in ten of 25 patients with Crohn's disease that had caused drug-resistant obstructions (five men, five women: mean age 45 [22-61] years). These patients had inactive Crohn's disease with 2-8 cm long stenoses in the rectum (n = 1), sigmoid colon (n = 2), terminal ileum (n = 2) or in the neoterminal ileum after a previous operation (n = 6). Nine of the eleven stenoses were successfully dilated, and seven of these eight patients continued to be pain-free during a follow-up period of 6-42 (average 17) months. The only complication was one case of bleeding. This experience indicates that endoscopic balloon dilatation is a valuable addition to surgical treatment in patients with inactive Crohn's disease associated with short, fibrotic stenoses.
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PMID:[Endoscopic balloon dilatation of symptomatic strictures in Crohn's disease]. 771 39

The value of an intravenous (i.v.) smooth muscle relaxant during barium follow through (BaFT) examination has been evaluated in a prospective study of 51 patients. Spot compression films pre- and post-relaxant were compared. Relaxant-induced hypotonia improved image quality in 33 (64.8%) patients by facilitating bowel loop separation and/or graded compression. Additional diagnostic information was obtained in 14 (27.5%), and reporting confidence was improved in 19 (37.3%) patients. A marked analgesic effect occurred in seven patients with Crohn's disease, ameliorating pain that otherwise prevented full compression. Intravenous relaxants are recommended when high tone makes compression difficult, to help separate overlying loops and where pain in Crohn's disease prevents adequate compression.
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PMID:Benefit of intravenous muscle relaxants during barium follow through. 814 7

A 27-year-old woman with a history of Crohn's disease and an allergy to penicillin presented for routine restorative dental work. Xylotox E80A (3.6 mL of 2% lidocaine with 1:80,000 epinephrine) was given, and the dental work was completed uneventfully. Three months later she presented with acute pulpitis of a mandibular molar for which root canal therapy was indicated. At this time, 1.8 mL Xylotox E80A was given. Within 2 minutes, the patient experienced severe respiratory distress and the procedure was delayed for 5 days. In a fully equipped operating room, a subcutaneous test with Xylotox E80A was performed and acute bronchospasm resulted. This case report describes severe bronchospasm following the administration of lidocaine on two occasions.
Anesth Pain Control Dent 1993
PMID:Acute bronchospasm following administration of lidocaine. 818 May 21

Eighteen patients with a syndrome of abdominal bloating and discomfort were examined to explore the relationship between their symptoms and their emotional problems. They were compared with 33 patients with Crohn's disease and 38 normal, healthy volunteers. Using the Hospital Anxiety and Depression Scale, patients with bloating were found to resemble patients with Crohn's disease. Both groups showed increased anxiety and depression. After controlling for age, sex, education, occupation, personality variables and childhood experience, there was a trend towards more anxiety in the bloating group compared with normal subjects and a significant difference for depression. These characteristics appear to be related to the effects of the illness or to selection, but not to personality or childhood experience. Although psychiatric problems are common among patients with abdominal bloating and pain who stay in touch with a clinic, they are not the primary cause of the disorder.
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PMID:Anxiety and depression in patients with abdominal bloating. 824 19


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