Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mother, father (26 y.o.) and their only child (5 y.o.) developed nonproductive cough, fever (39.5 to 40.4 degrees C) and bilateral pulmonary infiltrates within three weeks. In addition the mother developed a small left pleural effusion and a pericardial effusion, a relative bradycardia, a pruritic vesicular exanthem of the extremities and the trunk, an erythema nodosum and arthritis of the tarsal joints. The father's coulter counter red blood count was distorted by microagglutination at room temperature (hemoglobin 13.2 gr/dl; erythrocytes 1,91 X 10(6) mm-3 and MCH 69.1 pg; MCV 120 fl and hematocrit 23.8%) but not at 37 degrees C (13.2; 4.15 and 31.8; 92 and 39.3, respectively). In the daughter myringitis, pharyngitis, cervical lymphadenopathy and splenomegaly were observed. Cold agglutinins and serologic evidence for mycoplasma pneumoniae infection were demonstrable in all three. Treatment with Tetracycline (parents) and Erythromycin (child) was effective.
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PMID:[Familial Mycoplasma pneumonia. The varied picture of pulmonary and extrapulmonary manifestations]. 311 25

A case of rheumateid arthritis (RA) with pernicious anemia (PA) and wandering multiple patchy densities in bilateral lung fields is reported. A 72-year-old woman was hospitalized in February 1994, because of cough. She had already advanced RA (Class IV, Stage IV). She showed macrocytic and hyperchromic anemia as follows ; red-cell count (RBC), 176 x 10(4)/microliters; hemoglobin (Hb),7.2 g/dl; hematocrit (Ht), 21.0% ; MCV, 119.3 fl; and MCH, 40.9 pg. Chest roentgenogram revealed multiple patchy densities in bilateral lung fields and there was no response to the administration of antibiotic agents. From these clinical pictures bronchiolitis obliterans organizing pneumonia (BOOP) was highly suspected. After steroid injection into the joint space, the abnormal lung shadows disappeared. Anemia had been recovering spontaneously, but recurred in July. The results of blood examination were as follows ; RBC, 162 x 10(4)/microliters; Hb, 6.7ng/dl; Ht, 19.1%; MCV, 117.9 fl; and MCH, 41.4 pg. Anti-intrinsic factor antibody was positive. The level of serum vitamin B12 was low, 76 pg/ml. Sternal bone marrow aspiration showed magaloblastic changes with hypersegmentation of granulocytes. PA was diagnosed and improvement was noted after the intramuscular administration of vitamin B12. Subjective symptoms based on RA did not change during the clinical course. It is suggested that the pathogenesis about the combination of RA, BOOP and PA is related to common immunological abnormalities in our patient. A case of RA with PA and BOOP has not been reported previously, thus this case is considered clinically valuable.
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PMID:[A case of rheumatoid arthritis associated with pernicious anemia and bronchiolitis obliterans organizing pneumonia]. 872 Feb 71

Nepal is a mountainous Himalayan country. All the signs of underdevelopment--poverty, illiteracy, sickness, malnutrition, high birth rate, high infant mortality--are evident. Life in Panchkhal is not easy. Women work hard, fetching water from streams or ponds. There are no safe sources of water. Water-borne diseases are common because of fecal contamination of water. Unhygienic habits and unsanitary disposal of human excreta have resulted in a high incidence of parasitic infestation in the community. In 1983, community-based health care units were set up. Community members pooled funds for a community-based primary health care unit where drugs for diarrhea, scabies, dysentry, cough, fever, and eye infection would be made available at low cost. The Integrated Family Planning and Parasite Control Project has set up a sales depot to make drugs available at nominal prices. 2 health units were established in Panchkhal in 1983. There was a strong determination on the part of the community to improve the health status of the people, especially that of the uner-5s. The local village health workers were trained and assigned to work in the project area. Village health workers found the health unit a useful base. The importance of disease prevention was realized by the villagers. At present there are 9 health units. Each is run by 2 village health workers who receive salaries from either the integrated project of the government FP/MCH program. Social workers also provide services. A woman volunteer trained in basic MCH and family planning motivation assists the unit twice a week. The responsibility of the health committee is to ensure the smooth operation of the unit and to see that health care is provided to the villagers. Toilets have now been constructed in many homes. Children are healthier. Family planning is more acceptable to the community. The marketing of lacal produce is a problem, as well as funding of the health project.
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PMID:Making life easier in the rugged countryside through the Panchkhal Panchayat Health Movement. 1231 82