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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of glomus tumour of the trachea is reported. The patient, a 58-year-old man, complained of dyspnoea, cough and occasional haemoptysis for many years and had been misdiagnosed as having chronic bronchitis. The diagnosis of glomus tumour in a tissue sample taken by bronchoscopy was useful in planning adequate surgery. Light and electromicroscopy of the excised tumour confirmed the preoperative diagnosis. Immunohistochemical examination showed vimentin and actin in the tumour cells, and negativity for high and low molecular weight keratins, desmin, neurofilaments, and factor VIII-related antigen, findings similar to glomus tumours of other sites.
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PMID:Glomus tumour of the trachea: report of a case with microscopic, ultrastructural and immunohistochemical examination and review of the literature. 166 2

Alveolar adenoma of lung is a rare benign neoplasm of uncertain histogenesis. Its rarity hampers characterization of its epithelial and mesenchymal elements. Clinical and histopathologic features of 17 alveolar adenomas were reviewed. Histochemistry was performed on 10 cases, ultrastructural analysis on two, and immunohistochemistry on six cases for pneumocyte markers, thyroid transcription factor (TTF-1), surfactant protein markers pro-SP-B and pro-SP-C, and the Clara cell marker, CC10. Immunohistochemistry was performed in nine cases for desmin, smooth muscle actin, muscle-specific actin, cytokeratin, proliferating cell nuclear antigen (PCNA), factor VIII, and carcinoembryonic antigen. The mean age was 53 years. Seven cases occurred in men, and nine occurred in women. The age and sex were not known for one patient. The tumors were coin lesions on chest radiographs in asymptomatic patients except for one (cough). The mean size was 2.2 cm. The tumors were well demarcated with multiple cystic spaces containing granular material. Mostly type 2 pneumocytes lined the cystic spaces with fewer type 1 cells and no Clara cells. This was confirmed by staining for TTF-1, pro-SP-B, and pro-SP-C and by ultrastructure. CC10 was negative in all cases. The stroma varied from prominent spindle cells with a myxoid matrix to thin alveolar septa. The interstitial spindle cells resembled fibroblasts by immunohistochemistry and ultrastructure. Follow-up data available in five cases showed no recurrence at 2, 2, 5, 8, and 13 years. In summary, alveolar adenoma is a benign neoplasm consisting of an intimate admixture of alveolar epithelial and septal mesenchymal tissue. Most of the epithelial cells are type 2 pneumocytes, and the interstitial stromal cells are fibroblasts or fibroblast-like cells. Recognition of its characteristic morphological appearance allows for its distinction from other benign lesions of the lung.
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PMID:Alveolar adenoma: a histochemical, immunohistochemical, and ultrastructural analysis of 17 cases. 1002 43

Pulmonary epithelioid haemangioendothelioma (PEH) is a rare pulmonary neoplasm. A patient with PEH with lymph node and pleural metastases that were discovered incidentally is described. An abnormal left upper lobe shadow was noticed on CXR in a 70-year-old woman during an assessment for the sudden onset of nausea and vomiting. Transbronchial lung biopsy did not provide a diagnosis. Lobectomy and lymph node resection were performed. The histological diagnosis of PEH was confirmed immunohistochemically by positive reactions to factor VIII-related antigen and CD34. Data on 93 patients with PEH including the present case report were analysed by Cox regression analysis using forward stepwise method to identify the risk factors, and the independent predictors of survival in patients with PEH. It revealed that male, symptomatic patients, presence of cough, haemoptysis, chest pain, multiple unilateral nodules, pleural effusion, metastases to more than one site and lymph node metastases were all significant risk factors for PEH (P<0.05). Symptomatic patients and presence of pleural effusion were the independent predictors of survival in patients with PEH.
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PMID:Risk factors and independent predictors of survival in patients with pulmonary epithelioid haemangioendothelioma. Review of the literature and a case report. 1705 15

A 76-year-old man with a dry cough visited our hospital in June 2006. A chest X-ray showed opacification of the left hemithorax and CT demonstrated a soft tissue mass with pleural calcification. At first, we considered he had acute bronchitis with an old tuberculous pyothorax. But, his condition deteriorated with the additional complaint of a left chest pain and shortness of breath in September 2006. Consequently, he was admitted to our hospital. CT demonstrated that the soft tissue mass was growing and was invading the left rib and submammary tissue. Neither CT nor sonographically guided fine needle biopsies and cytological examinations were helpful in diagnosing this disease. He died of respiratory failure 2 months after admission. Autopsy revealed pyothorax and a hemorrhagic tumor from the left side of the thoracic cavity to the chest wall. Microscopic examination showed that atypical cells had proliferated and formed vascular structures, which were stained positively with anti-factor VIII antibody. Finally, the diagnosis was made of pyothorax-associated pleural Angiosarcoma. Angiosarcoma is rare and difficult to diagnosis, however, we have to keep in mind the presence of disease pyothorax-associated pleural angiosarcoma.
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PMID:[A case of pyothorax-associated pleural angiosarcoma diagnosed by autopsy]. 1967 Aug

We report 9 cases of primary angiosarcomas of the anterior mediastinum. Patient ages ranged from 25 to 62 years (mean, 40.7 years); 5 patients were male and 4 were female. Main presenting symptoms included chest pain, dyspnea, and cough. The tumor size ranged from 3 to 12.5 cm. Macroscopically, the lesions were ill-defined hemorrhagic masses. Histologically, the growth patterns ranged from large vascular spaces to capillary-like proliferations. These were either lined by bland or more pleomorphic endothelial cells. The mitotic activity was variable and corresponded to the degree of differentiation. A rim of thymic tissue was observed in 2 cases suggesting a thymic origin of the tumors. No teratomatous components were identified. Immunohistochemical studies showed that all 9 cases were reactive for vascular markers including factor VIII-related antigen, CD31, and CD34, and negative for cytokeratin CAM5.2. All cases were treated by complete resection and 3 patients received adjuvant chemotherapy. Follow-up information available for 6 patients revealed that 4 were alive and free of disease at intervals ranging from 6 to 36 months after diagnosis and 1 was alive with recurrence at 48 months. One patient had died of the disease 10 months after diagnosis. Primary angiosarcomas of the anterior mediastinum are rare tumors that need to be added to the differential diagnosis of primary anterior mediastinal neoplasms. Despite their histologic similarity to angiosarcomas at other sites, primary angiosarcomas of the anterior mediastinum appear to follow a more protracted clinical course than their counterparts in other organ systems.
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PMID:Primary angiosarcomas of the anterior mediastinum: a clinicopathologic and immunohistochemical study of 9 cases. 2070 59

Acquired hemophilia A (AHA) is a rare disease induced by autoantibodies to factor VIII (FVIII) and may be correlated with pregnancy, underlying malignancies, autoimmune diseases or drug administration. An 81-year-old man who presented with cough, expectoration, hemoptysis and multiple ecchymoses was diagnosed with community-acquired pneumonia by computed tomography scan. Respiratory symptoms were ameliorated after the application of antibiotics. Despite repeated infusion of fresh frozen plasma and cryoprecipitate, his prolonged activated partial thromboplastin time (APTT) maintained in the 75-110-s range and ecchymoses were not ameliorated. Then, he was transferred to the department of hematology. Based on a prolonged APTT, decreased level of FVIII and presence of antibodies against FVIII, the patient was diagnosed with AHA. Then the patient was treated with activated prothrombin complex concentrates, prednisone and intravenous immunoglobulin, resulting in a complete remission of the bleeding, recovering the FVIII level and negativity for FVIII antibody titers. Here, we investigate this novel case retrospectively and review the relevant literature.
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PMID:Acquired hemophilia A in a patient associated with community-acquired pneumonia. 2406 3

Epithelioid hemangioendothelioma is a multifocal tumor that rarely metastasizes. It is difficult to diagnose, most often it is an incidental finding in young asymptomatic women. The radiologic pattern is heterogeneous. Histologic confirmation of Weibel-Palade bodies or immunohistochemistry based on specific tumor markers such as factor VIII and CD34 are the most important finding to confirm the diagnosis. We report a 21 years old woman Presenting with cough and dyspnea. A chest X ray was suggestive of tuberculosis. Sputum smears were negative for acid fat bacilli and the tuberculin test was negative. A chest CAT scan showed multiple nodular lesions. A surgical biopsy of the lesions confirmed the presence of a hemangioendothelioma. The patient was initially treated with prednisone and azathioprine without response. Thereafter, the patient is without treatment and without evidence of disease progression.
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PMID:[Lung epithelioid hemangioendothelioma: Report of one case]. 2889 44