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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The methanol extract of Leucas lavandulaefolia was investigated for its effects on a cough model induced by sulfur dioxide gas in mice. It exhibited significant antitussive activity when compared with control in a dose-dependent manner. The antitussive activity of the extract was comparable to that of codeine phosphate (10 mg/kg), a prototype antitussive agent. The Leucas lavandulaefolia extract at 100, 200, and 400 mg/kg. p.o. showed inhibition of cough by 35.0, 51.9, and 56.5% within 1 h of performing the experiment.
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PMID:Studies on in vivo antitussive activity of Leucas lavandulaefolia using a cough model induced by sulfur dioxide gas in mice. 925 11

The anticough activity of Psidium guajava Linn. (guava) leaf extract was evaluated in rats and guinea pigs. The results showed that water extract of the plant at doses of 2 and 5 g/kg, p.o. decreased the frequency of cough induced by capsaicin aerosol by 35 and 54%, respectively, as compared to the control, within 10 min after injection of the extract, (P < 0.01). However, the anticough activity is less potent than that of 3 mg/kg dextromethorphan which decreased frequency of cough by 78% (P < 0.01). An experiment on isolated rat tracheal muscle showed that the extract directly stimulated muscle contraction and also synergized with the stimulatory effect of pilocarpine. This effect was antagonized by an atropine. Moreover, growth of Staphylococcus aureus and beta-streptococcus group A, as determined by the disc diffusion method, was inhibited by water, methanol and chloroform extract of dry guava leaves (P < 0.001). The LD50 of guava leaf extract was more than 5 g/kg, p.o. These results suggest that guava leaf extract is recommended as a cough remedy.
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PMID:Anticough and antimicrobial activities of Psidium guajava Linn. leaf extract. 1061 85

The antitussive activity of a methanol extract of Jussiaea suffruticosa Linn. (MEJS) (family Onagraceae) leaves has been evaluated for its potential on a cough induced by sulphur dioxide (SO(2)) gas model in mice. The extract (MEJS) showed significant antitussive activity in a dose dependent manner. The antitussive potential of MEJS was comparable to that of codeine phosphate (10 mg/kg), a standard drug. The extract (MEJS) at a dose level of 200 and 400 mg/kg, p.o. showed appreciable inhibition on the cough reflex by 48.52% and 59.8% respectively during 120 min of the experiment.
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PMID:Evaluation of antitussive potential of Jussiaea suffruticosa linn. extract in albino mice. 1105 46

The methanol extract of Asparagus racemosus root (200 and 400 mg/kg, p.o.) showed significant antitussive activity on sulfur dioxide-induced cough in mice, the cough inhibition (40.0 and 58.5%, respectively) being comparable to that of 10-20 mg/kg of codeine phosphate (36.0 and 55.4%, respectively).
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PMID:Antitussive effect of Asparagus racemosus root against sulfur dioxide-induced cough in mice. 1107 76

An efficient method combining SEP-PAK C18 cartridge solid phase extraction (SPE) with reversed-phase high performance liquid chromatography for the quantitation of morphine in the Compound Liquorice Tablet is presented. The tablets have been used for making expectoration easy and relieving cough for years. The tablet powder (approximately 1 tablet) was added into a stoppered centrifuge tube, and vertically extracted with 5 mL of 0.5% HAc for 5 min. After centrifugation the supernatant was transferred to a beaker and the extraction was repeated twice with 4 mL and then 3 mL of 0.5% HAc. Five millilitres of carbonate buffer (pH 8.9) was added to the combined extracts. A SEP-PAK C18 cartridge was pretreated by passing methanol and distilled water, using a glass syringe. The mixture was applied on it and allowed to flow through. The cartridge was washed first with 5 mL of 10% methanol solution and then the morphine was eluted with 4 mL of 70% methanol solution into a 5 mL volumetric flask and was finally diluted to volume with 70% methanol solution. Analysis was performed on a mu-Bondapak C18 column(300 mm x 4.6 mm i.d., 10 microns) with 0.1 mol/L NaH2PO4-methanol(5:1) as the mobile phase and detection at 286 nm. The average recovery of morphine was (101.2 +/- 1.5)% and RSD was 1.5%. The method is simple, rapid, accurate, and reproducible, and can be used in drug control.
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PMID:[Determination of morphine in compound liquorice tablets by high performance liquid chromatography with SEP-PAK C18 cartridge pretreatment]. 1132 1

The chromatographic behaviour of binary and ternary mixtures of several phenethylamines (phenylephrine, phenylpropanolamine, ephedrine, pseudoephedrine and methoxyphenamine) and antihistamines (pheniramine, carbinoxamine, doxylamine, chlorpheniramine, dexchlorpheniramine, dexbrompheniramine, diphenhydramine, tripolidine, azatadine and phenyltoloxamine), found in cough-cold pharmaceutical preparations, was studied using C8, C18 and cyano columns, micellar mobile phases of sodium dodecyl sulfate (SDS) and pentanol and UV detection. Using a C8 column and mobile phases of 0.05 mol l-1 SDS-6% v/v pentanol or 0.15 mol l-1 SDS-2% v/v pentanol at pH 7, more than 30 different phenethylamine-antihistamine combinations can be resolved in < 15 min. Intra- and inter-day repeatabilities and reproducibilities evaluated at three different drug concentrations (0.5, 5 and 25 micrograms ml-1, n = 10) were below 1.6, 2.5 and 2.4%, respectively. The drug amounts found in 18 formulations agreed with those declared by the manufacturers within the tolerance limits, and with those obtained using a mobile phase of 55% v/v methanol at pH 7. No interference was observed from other accompanying drugs such as acetylsalicylic acid, ascorbic acid, betamethasone, bromhexine, caffeine, codeine, dextromethorphan, paracetamol, prednisolone, salicylamide and tartrazine. The proposed procedure has the advantage over the conventional aqueous-organic procedure of using a small amount of organic solvent, which is highly retained in the SDS solution. The efficiencies are also greater. On the other hand, in the micellar system, the retentions of phenethylamines and antihistamines are similar, although the compounds can be easily resolved. In contrast, using the methanol-water mobile phase, the phenethylamines are weakly retained, whereas the antihistamines usually show a high retention.
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PMID:Chromatographic analysis of phenethylamine-antihistamine combinations using C8, C18 or cyano columns and micellar sodium dodecyl sulfate-pentanol mixtures. 1134 Sep 78

The methanol extract of the rhizome of Bergenia ciliata Sternb. (Saxifragaceae) has been evaluated for its potential in a cough model induced by sulphur dioxide gas in mice. The extract exhibited significant anti-tussive activity in a dose-dependent manner, as compared with control. The antitussive activity of the extract was comparable to that of codeine phosphate (10 mg/kg body wt.), a standard anti-tussive agent. The extract at doses of 100, 200 and 300 mg/kg body wt. (p.o.) showed significant inhibition of cough reflex by 28.7, 33.9 and 44.2%, respectively, within 90 min of the experiment.
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PMID:Evaluation of anti-tussive activity of Bergenia ciliata Sternb. rhizome extract in mice. 1151 20

The effect of methanol extract of whole plants of Trichodesma indicum R. Br. has been investigated on sulphur dioxide (SO2) induced cough reflex in Swiss albino mice. The extract has demonstrated significant (p < 0.001) inhibition in frequency of cough in all the tested doses when compared with untreated control group. The effect persisted up to 90 min of its oral administration and also comparable to that of the effect exhibited by the standard drug (Codeine phosphate). This study confirmed the traditional use of this plant in the treatment of cough. Determination of underlying mechanism of beneficial effect is major topic requiring further comprehensive investigation.
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PMID:Effect of Trichodesma indicum extract on cough reflex induced by sulphur dioxide in mice. 1192 68

The methanol extract of the leaves of Passiflora incarnata (100 and 200 mg/kg, p.o.) exhibited significant antitussive activity on sulfur dioxide-induced cough in mice, the cough inhibition (39.4 and 65.0%, respectively) being comparable to that of codeine phosphate (10 and 20 mg/kg, p.o., respectively).
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PMID:Antitussive activity of the methanol extract of Passiflora incarnata leaves. 1216 35

The present paper describes a simple, accurate and precise reversed phase HPLC method for rapid and simultaneous quantification of codeine phosphate, ephedrine HCl and chlorpheniramine maleate in a cough-cold syrup formulation. Separations were carried out on a Zorbax XDB C8 column (150 x 4.6 mm ID), 5 microm particle size. A gradient elution system was developed using varying percentages of two mobile phases: methanol-glacial acetic acid-triethylamine (980:15:6 v/v) and water-glacial acetic acid-triethylamine (980:15:6 v/v). The elution of the analytes was achieved in less than 7 min with a flow rate of 1.5 ml/min. Detection was by UV absorbance at a wavelength of 254 nm. Quantification of the components in actual syrup formulations was calculated against the responses of freshly prepared external standard solutions. The method was validated and met all analysis requirements of quality assurance and quality control recommended by FDA of the USA.
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PMID:A chromatographic method for rapid and simultaneous analysis of codeine phosphate, ephedrine HCl and chlorpheniramine maleate in cough-cold syrup formulation. 1246 31


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