Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Children six months to four years of age are at greatest risk for aspiration of foreign bodies. A history of coughing after contact with small objects is the most important clue. The clinical presentation varies from paroxysms of choking and coughing to chronic cough or wheezing. Chest radiographs are normal in up to one-half of the children. The location and size of the foreign body determine the urgency and selection of therapy. Prevention and a high index of suspicion will decrease morbidity.
Am Fam Physician 1979 Sep
PMID:Aspirated foreign bodies in children. 47 60

Isoaminile (Peracon) has found in Italy a certain success as a substitute for hard narcotcis. Three observations are reported in which five young adults have been intoxicated by the i.v. administration of the cough suppressant. On the basis of two opposed points of view suggested by the Literature to explain the compulsive abuse of this drug, the A. have studied its physical dependence capacity by using an original technique. The isoaminile cyanide release has been measured too. The experimental results demonstrate that isoaminile does not determine a physical dependence; a slight CN- release activity occurs in vivo only with high doses.
Arch Toxicol 1979 Sep
PMID:Some cases of acute intoxications from compulsive use of isoaminile. 51 94

Chlamydia trachomatis was isolated from the epipharynx of a 10-week-old baby girl taken ill with pneumonia but without signs of conjunctivitis. The infant developed specific antibodies to the organism. The course of the pneumonia was protracted, with cough and tachypnea. The baby, who was afebrile, improved on antibiotic therapy but pulmonary infiltrates persisted for several months. To our knowledge, this is the first case of pneumonia in an infant associated with C. trachomatis infection reported elsewhere than North America.
Acta Paediatr Scand 1979 Sep
PMID:Pneumonia associated with Chlamydia trachomatis infection in an infant. 52 46

The effect of the amphetamine in coughing by trachial excitation and the delay of respiration by laryngial excitation is studied in experimental investigations in dogs, a very significant decrease of the two responses is produced in the dosis of 1 mg/kg.
Rev Med Univ Navarra 1979 Sep
PMID:[Antitussive effect of amphetamine]. 55 31

During a survey of disease due to M. ulcerans in a small rural community in Uganda in 1971 individuals were asked whether they had a cough and how long it had been present. Nine thousand one hundred and seventy-two were questioned. Of these, 4.0% of males and 4.2% of females reported a cough of longer than 1 month's duration. Of 909 aged 50 years or more the proportion was 7.9% being higher in females (9.8%) than in males (6.5%).
Tubercle 1977 Sep
PMID:The prevalence of persistent coughs in a rural community in the Lango district of Uganda. 59 45

Several antitussive agents were assessed for their cough-suppressant activity. Cough responses were obtained by electrically stimulating the lower brainstem, in cats lightly anesthetized with sodium pentobarbital or in unanesthetized midcollicular decerebrate preparations. Cough sounds were recorded with the aid of a microphone. The cough reactive region was concentrated in an area dorsomedial to the trigeminal tract and nucleus. The potency of these antitussive agents (dextromethorphan, RO 21-4790-001, codeine, clonazepam, diazepam and caramiphen) were determined by studying their effect on the centrally induced cough responses. Each of these agents was administered in graded doses intravenously to determine the minimal effective doses for suppressing the cough responses. They are 0.57, 2.55, 1.71, 0.048, 0.28 and 3.18 mg/kg for the above listed drugs. The results indicate that clonazepam was found to be the most potent antitussive among these agents, the mean effective dose being about 1/35 of that of codeine. The antitussive potency of benzodiazepines is not well correlated with their muscle relaxant activity. For instance, clonazepam and diazepam have the same potency in depressing polysynaptic spinal reflexes, whereas the former is six times more potent than diazepam as an antitussive. This finding indicates that clonazepam has a high specificity as an antitussive.
Agents Actions 1977 Sep
PMID:Studies on the potency of various antitussive agents. 59 17

After receiving reports of lead poisoning in two workers at a secondary lead smelter, we evaluated the health status of 38 current smelter workers and 87 of their household contacts by questionnaires, physical examinations, and laboratory tests. Fatigue, cough, and diarrhea were the most frequent symptoms in plant employees; each occurred in at least a third. The most frequent physical finding, hand tremor, occurred in 10 of 33 plant employees. Twelve employees had blood lead concentrations at or above 80 microgram/100 ml, and 17 others had blood lead concentrations at or above 60 microgram/100 ml. All physical signs possibly due to excess lead absorption were manifested by employees with blood lead levels of 60 microgram/100 ml or greater, with one exception. Household contacts of employees had few symptoms suggestive of excess lead absorption.
J Occup Med 1977 Sep
PMID:Chronic occupational exposure to lead: an evaluation of the health of smelter workers. 59 90

Increasing intraperitoneal pressure during inguinal herniography by inducing infants to forcefully cry and older children to forcefully cough will enhance opacification of peritoneal sacs that are either not apparent or only minimally opacified during routine filming. The maneuver is performed with fluoroscopy, and spot films are obtained. The technique is discussed and three cases are illustrated.
Radiology 1978 Sep
PMID:A technique for enhancing the visualization of "peritoneal sacs" during inguinal herniography. 67 79

Twenty-four cases of Legionnaires' disease were diagnosed at the Wadsworth Veterans Administration Hospital during a 5-month period. All cases occurred in persons exposed to the hospital environment during the usual incubation period of Legionnaires' disease. The clinical illness was quite characteristic. All patients complained of weakness, malaise, anorexia, and cough. Rigors, diarrhea, and pleuritic pain were frequent symptoms. All patients had a maximum temperature of greater than or equal to 39.4 degrees C. Thirteen of 22 patients had relative bradycardia. Chest roentgenograms documented pneumonia in all patients. Leukocytosis, hyponatremia, hypophosphatemia, and abnormal liver-function test results were typical. Diagnosis was made by serologic criteria in 20 patients, postmortem examination of tissue in two, and both serology and tissue examination in two. Four patients in whom the disease was not suspected died of Legionnaires' disease. One patient died of unrelated causes. Fifteen of 19 survivors received erythromycin therapy. The presentation of Legionnaires' disease was characteristic enough to allow early, specific therapy.
Ann Intern Med 1978 Sep
PMID:Legionnaires' disease: clinical features of 24 cases. 68 39

Pulmonary disease has been associated with several chemotherapeutic agents but has not been reported in patients receiving the alkylating agent mitomycin (Mutamycin). We describe here the cases of three patients who developed interstitial pneumonia while receiving mitomycin therapy. Their clinical features including dyspnea, cough, and occasionally fever; reticular infiltrates were seen on chest roentgenogram. Histologically, diffuse alveolar septal edema, mononuclear-cell interstitial infiltrates, hypertrophy of alveolar lining cells, and alveolar septal collagen deposition were characteristic. Treatment with corticosteroids was associated with a rapid therapeutic response in all three patients.
Ann Intern Med 1978 Sep
PMID:Interstitial pneumonia from mitomycin. 68 48


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