Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intracranial pressure (i.c.p.) and mean arterial pressure (m.a.p.) were studied in 20 patients during the induction of anaesthesia for craniotomy. Tubocurarine was administered as the muscle relaxant and either thiopentone or Althesin for the induction of anaesthesia. No significant differences were found in the i.c.p. changes with induction, intubation or pharyngeal packing, between the thiopentone and the Althesin groups. Except for two patients (one in each group) the increases in i.c.p. associated with intubation were small. In these two patients moderate increases from normal values to 28 and 37 mm Hg were recorded, but in one of these patients coughing and straining followed intubation. Marked decreases in m.a.p. were noted in both groups, but the recovery of m.a.p. was significantly more rapid in the Althesin group. Only two patients had i.c.p. values greater than 20 mm Hg before operation and in neither did i.c.p. increase above control values during induction and intubation. Packing the pharynx produced minimal changes in i.c.p. in all patients.
 ...
PMID:Effects of tracheal intubation on intracranial pressure following induction of anaesthesia with thiopentone or althesin in patients undergoing neurosurgery. 65 51

d-Tubocurarine (dTc) was administered intravenously to six healthy unanesthetized volunteers to assess the effects of partial paralysis on ventilatory response to CO2. Each subject received during a 40-minute period 0.2 mg/kg, consisting of five incremental doses at intervals 10 minutes apart. Isohypercapnia with PETCO2 6-7 torr above each subject's resting level was maintained throughout dTc administration. Ventilation at this level of stimulus was 23.8 +/- 1.1 1/min (mean +/- SE) before administration of dTc, about three times resting levels. Steady-state minute ventilation measured during the period 4-6 minutes after each dose of dTc failed to decrease significantly; the levels of ventilation were maintained principally by increased respiratory frequency, since tidal volumes declined significantly from an average of 1,550 ml to 1,050 ml (P less than 0.025). Changes in the slope of the CO2-response curve varied widely among subjects. Although the control slope of 2.65 +/- 0.76 1/min/torr (mean +/- SE) was reduced to 1.50 +/- 0.36 1/min/torr after partial curarization, the change was not significant (P greater than 0.10) Ventilation was maintained at a time when grip strength was 6 per cent of control, vital capacity was 52 per cent of control, and maximum static respiratory pressures were 35-40 per cent of control. Nevertheless, the results suggest significant impairment of vital respiratory functions such as coughing, deep breathing, and the ability to maintain a patent airway in the absence of endotracheal intubation.
 ...
PMID:Partial paralysis with d-tubocurarine and the ventilatory response to CO2: An example of respiratory sparing? 93 46