Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Leukotriene C4 (LTC4) is a major component of slow-reacting substance of anaphylaxis (SRS-A) and is a potent bronchoconstrictor. In humans LTC4 results in bouts of coughing which suggests stimulation of pulmonary receptors involved in a reflex mechanism. Furthermore, atropine reduces the effect of both LTC4 and SRS-A. To test the hypothesis that LTC4 stimulates the rapidly-adapting or "irritant" receptor (RAR) of the airways, we administered LTC4 by both intravenous injection (10-1000 ng) and by aerosol delivery (1 microgram/ml) to the lungs of guinea pigs while recording arterial blood pressure, intratracheal pressure, and nerve activity from RARs. LTC4 (i.v.) concurrently increased both nerve activity and intratracheal pressure even at low doses in a dose-dependent manner. Therefore, a direct action of LTC4 (i.v.) upon the RAR is difficult to conclude. The separation of peak tracheal pressure and peak nerve activity was apparent with aerosol delivery of LTC4. The pattern of RAR activity during LTC4 aerosol challenge was unrelated to respiratory phase. FPL 55712 blocks the effects of SRS-A. We challenged the lung with 500 ng LTC4 intravenously before and after FPL 55712 injection (2.5 mg/kg). FPL 55712 blocked the increases of both tracheal pressure and RAR activity.
 ...
PMID:Rapidly-adapting receptor activity and intratracheal pressure in guinea pigs. I. Action of leukotriene C4. 659 47

Pulmonary responses to aerosols of synthetic leukotrienes C and D were examined in two normal volunteers. The leukotrienes were equipotent and equieffective in producing moderate bronchoconstriction accompanied by coughing. Changes in FEV1 were slight, but changes in expiratory flow at low lung volumes were more notable. FPL 55712 abolished the cough response and partially inhibited the bronchoconstriction.
 ...
PMID:Leukotrienes C and D induce bronchoconstriction in man. 689 14