Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The artificially induced cough reflex in experimental animals should necessarily be similar to the cough which occurs naturally in humans. The curve demonstrated during a cough of each patient with respiratory disease was characteristic. Compared with the curve of a cough-like reflex (CLR) induced by DMPP, the curve of a cough induced by electrical stimulation of the tracheal mucosa was similar to that of a cough in humans. In dogs and cats anesthetized with alpha-chloralose (80 similar to 100 mg/kg i.p.), the number of CLR with DMPP was dose dependent. Tachphylaxis did not occur despite repeated administration of DMPP. DMPP (5 similar to 10 mug/kg i.v.) did not affect airway resistance. CLR with DMPP was depressed not only by morphine, codeine, oxymethebanol, picoperidamine, piclobetol and hexacol but also by hexamethonium. Thus, it appears that the mechanism of CLR with DMPP is different from that in the cough reflex. This CLR may be utilized for determining the physiology of cough reflex and the site of action of antitussives.
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PMID:[Pharmacological studies on the cough reflex]. 116 90

The phrenic nerve activity is an appropriate indicator for the output of the respiratory center as a whole, although a quantitative analysis of each of the frequency band components that constitute the neural activities during the respiratory reflex has not yet been made by other investigators. In the present study, we have made a quantitative analysis of each of the frequency band components of phrenic nerve activity during the cough reflex in anesthetized dogs. The efferent activities of the phrenic nerve were recorded from the central cut end of the phrenic nerve. Each fraction of phrenic nerve activity was separated into bands spanning a range of 100 Hz each by a variable filter and analyzed using a program for the power spectrum. The cough reflex was induced by mechanical stimulation of the tracheal mucosa. In the power spectrum analysis of each frequency band, increase in the power of each of the frequency band components was observed during the cough reflex. Particularly, the power of the 2 approximately 100 Hz band components increased significant as compared with the other frequency band components. Such as increase in the power of the 2 approximately 100 Hz band components toward the other frequency band components during the cough reflex was not observed after an i.v. administration of DMPP and lobeline, but the power increased extended over every frequency band. These findings suggest that the process for integrating the cough reflex was different from that of the other respiratory reflexes and that the present method is useful for investigating the central mechanisms of the cough reflex.
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PMID:[A quantitative analysis of the phrenic nerve activities during the cough reflex]. 712 43