Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two patients were hospitalized because of fever, cough and dyspnea and an interstitial infiltrate of both lungs that was shown to be a lymphangitic spread of prostate carcinoma. The presentation of prostatic carcinoma as interstitial lung disease is rare, and emphasizes the importance of rectal examination and determination of acid phosphatase in the context of interstitial lung disease.
 ...
PMID:Carcinoma of the prostate presenting as interstitial lung disease. 358 79

Hairy cell leukemia is a chronic lymphoproliferative disorder affecting middle-aged adults, with the median age of 50-55 years. The majority of the patients present with cytopenia. A high count is usually a feature of the hairy cell leukemia variant. We report a case of a 23-year-old male who presented with fever and cough of 15 days duration. His peripheral blood count was 63 x 10(9)/l. His peripheral blood and bone marrow smear showed hairy cells which were positive for tartarate-resistant acid phosphatase stain. Surface markers and electron microscopic study on peripheral blood ruled out hairy cell leukemia variant as a differential diagnosis.
 ...
PMID:Hairy cell leukemia--an unusual presentation. 763 96

An outbreak of infectious influenza was recognized in Menofeia governorate in October 1989. Eight naturally influenza infected as well as 8 healthy control horses, mules and donkeys were selected for collection of blood and sera separation to estimate four lysosomal enzymatic activities and to describe the clinical findings, which were fever, congested nasal, conjunctival membranes and cough. Bronchopneumonia followed later with bilateral purulent nasal discharge as a complication in 2 donkeys. Thereafter laboured breathing occurred. Therefore a therapeutic penicillin-streptomycin dose was injected to safeguard against the secondary bacterial invasion. All lysosomal enzyme levels in serum of diseased equines were subjected to consistent regression except N-acetyl-beta-glucosaminidase -beta-NAG) that behaved very highly significant activity, probably due to the acid pH resulting from bronchopneumonia and respiratory acidosis which override the inhibitory action of the antibiotics. Influenza virus may inhibit the synthesis of the pulmonary surfactant in alveolar and bronchial epithelium, thereafter, the animals suffered from respiratory distress and bronchospasm with resultant decreased acid phosphatase (ACP) value which was histochemically located in both sites. The disappearance of alpha- and beta-galactosidases (alpha-GAL & beta-GAL) from the serum of diseased animals can be attributed to the antibiotic dose.
 ...
PMID:Characterization of serum lysosomal enzymatic activities. III. Effect of infectious influenza in Egyptian equines. 838 24