Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to explore the correlation between parents' smoking habits and bronchial asthma in children, we undertook a cross-sectional study of 3300 (54% males, 46% females) school children aged 7-12 years old. A survey of smoking habits and attitudes conducted in Saudi Arabia showed a positive correlation between parental smoking and asthma. This study showed a significant link between parental smoking and chest wheeze or whistling, cough, and family history of rhinitis. Evidence is accumulating that there is a relationship between parental smoking and respiratory symptoms in Saudi children. The present study results are clear evidence of a definite association between smoking in the home and bronchial asthma in young children, which not only may present immediate problems, but may also be a cause of illness in the future.
J Asthma 1991
PMID:Parental smoking and the risk of childhood asthma. 189 81

The new International Union Against Tuberculosis (IUAT) bronchial symptoms questionnaire was completed by 827 subjects participating in a prospective study of respiratory symptoms and lung function in aluminum smelter workers. A modified Medical Research Council (MRC) questionnaire was also administered. Bronchial reactivity (BR) was measured in 809 subjects by methacholine challenge using a rapid method. Factor analysis demonstrated sensible clustering of responses to items unique to the new questionnaire such as nocturnal, spontaneous, and postexertional dyspnea, dust-induced dyspnea and tightness, and breathing difficulty. Responses to IUAT questions concerning past asthma, wheeze, chest tightness, morning cough and sputum, and asthma medication agreed well with corresponding items from the MRC questionnaire. Questions concerning asthma, medication, dust-induced, nocturnal, and spontaneous dyspnea, chest tightness, wheeze, nocturnal cough, postexertional dyspnea and breathing difficulty also had high validity against the criterion of concurrently measured bronchial reactivity. It is concluded that the IUAT questionnaire is a valid asthma questionnaire.
J Asthma 1991
PMID:Evaluation of a new asthma questionnaire. 201 60

The efficacy of phenytoin (PHT) for the relief of chronic asthma was evaluated in an open trial in 190 intractable rural asthmatics. Our data indicate that phenytoin (100 mg po bid for adults and 50 mg po bid for children) is a useful antiasthmatic agent used either alone, or as adjuvant therapy. Phenytoin significantly reduced the frequency and severity of asthma attacks, coughing, nocturnal awakenings, and work absenteeism, and improved effort tolerance and subjective sense of well being. Phenytoin also reduces corticosteroid requirements of steroid-dependent patients. Not only were these results sustained over the course of 12-month treatment, but more than 60% of phenytoin-treated patients could be discontinued without recurrence of symptoms.
J Asthma 1991
PMID:Effect of phenytoin sodium in the management of poorly controlled bronchial asthma at a rural health center in Phalodi, Rajasthan, India. 207 54

We report two asthmatics working in the same factory who exhibited late asthmatic responses (LAR) to ethylenediamine (EDA) vapor. After several months of exposure to EDA, both patients developed productive coughing, wheezing, and dyspnea. Provocative inhalation tests using EDA evoked LAR in both patients, but it did not evoke any asthmatic symptoms in healthy subjects. IgE antibodies to EDA examined by intracutaneous and P-K tests were detected. It appears that, in these two cases, LAR are mainly due to immediate-type allergic reactions.
J Asthma 1990
PMID:Ethylenediamine-induced late asthmatic responses. 221 92

A practical and portable method is described to analyze the sound spectra of coughs. The system is based upon a personal computer and simultaneously collects the sounds of cough heard both at the mouth and through the chest wall together with the airflow at the mouth produced during the cough. Subsequent analysis produce spectrographs of the cough sound linked to the corresponding airflow. The system will be used initially to examine the effects of exercise on the sound of cough in asthma. Further study of cough spectra in this way may be useful in the management of asthma either diagnostically or in the assessment of therapeutic interventions.
J Asthma 1990
PMID:A portable system for the spectral analysis of cough sounds in asthma. 226 70

Analysis of 187 children diagnosed as having asthma since 1984 in a general practice population is described. Reasons were sought for possible delay in diagnosis so that appropriate steps could subsequently be taken to minimize further delay. Even in an asthma aware practice (original prevalence 8.8%) a delay of approximately 40% of the total age of the child at diagnosis is shown. This delay does not appear to diminish even for children up to 10 years of age. Asthma is more likely to be missed or labelled as 'bronchitis' in children who cough repeatedly, rather than those who wheeze occasionally. As many as 45% of asthmatic children may have had 'bronchitis' diagnosed and treated instead of asthma, so that a diagnosis of repeated 'bronchitis' merely detracts from underlying asthma.
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PMID:The effect of symptom presentation on delay in asthma diagnosis in children in a general practice. 237 36

In a 12-week double-blind, group comparative trial, preceded by a 2-week baseline period, 38 asthmatic subjects of mixed aetiology and varying severity received either 4 mg nedocromil sodium by metered dose inhaler twice a day or a matching placebo preparation, in addition to their existing maintenance therapy of inhaled corticosteroids plus inhaled bronchodilators. Asthma severity and lung function were assessed at 4-weekly clinic visits, and symptomatology (morning tightness, daytime asthma, cough, night-time asthma), morning, afternoon and evening PEFR, and the use of inhaled bronchodilators were recorded on daily diary cards. Treatment with nedocromil sodium led to significant (P less than 0.05) improvements in clinic assessment of FEV1 and PEFR both before and after an inhaled bronchodilator from at least the eighth week onwards. Mid-study FVC was also significantly (P less than 0.05) improved. Daily PEFR increased throughout the study in the nedocromil sodium-treated subjects and the diurnal variation was reduced. Daily symptom severity was also reduced and these improvements occurred despite the similar or slightly reduced use of inhaled bronchodilators. However, none of these improvements in diary card parameters reached statistical significance. By the final week of the study subjects treated with nedocromil sodium predominantly had a mild form of asthma or no symptoms at all, and both patients and clinicians reported the effectiveness of nedocromil sodium; the subjects but not the clinicians finding it significantly more effective (P less than 0.05) than placebo. Nedocromil sodium was well tolerated although one patient was withdrawn owing to a persistent sore throat after 7 weeks of treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Effects of adding nedocromil sodium (Tilade) to the routine therapy of patients with bronchial asthma. 255 69

Bronchial side effects of drugs are varied and numerous. The most frequent are the hypersensitivity type 1 and 3 reactions of asthma. Asthma is primarily caused by anti-infectious agents but also by protein drugs (and many others). At the present time, attention is being focused on excipients and solvents: cremophore, anti-oxidative sulfites (E 220 to E 227), found in over 700 drugs and responsible for severe side effects. Other bronchospasms are due to direct or indirect potentiation of parasympathetic bronchomotor tonus, chiefly with alpha-agonists, and perhaps with beta-agonists but this remains to be proven. Asthmatic reactions caused by interference in mediator synthesis are another current topic of study; some are well known, such as histamine release and interference in arachidonic acid metabolism (non-steroidal antiinflammatory drugs). Other side effects are the result of local irritation, obstruction or bronchial stenosis. A drug-induced cough could be a consequence of local irritation or of the action of converting enzyme inhibitors on bradykinin catabolism.
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PMID:[Bronchial manifestation of drug-induced complications]. 257 62

The aim of this study was to evaluate the causes of prolonged cough in a patient population referred to a chest clinic during a single year. One hundred and ninety-eight patients (11%) of the total yearly 1745 adult admissions fulfilled our criteria of prolonged cough. Asthma, suspicion of asthma and postnasal drip were the commonest causes of prolonged cough in 147 patients with normal chest roentgenograms (26%, 9% and 16%, respectively), and in 45% the cough was of unexplained origin. Nonspecific bronchial hyperreactivity was common in this latter group of patients probably due to a previous respiratory infection. Lung cancer (37%), tuberculosis (16%), sarcoidosis (16%), and allergic alveolitis (9%) were the most important findings in patients with abnormal chest roentgenograms.
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PMID:Causes of prolonged cough in patients referred to a chest clinic. 260 35

To study the possible role of alpha-2 receptors in intractable asthmatics, we investigated the ameliorative effects of 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylthyl]pyridine dihydrochloride sesquihydrate (DG-5128) on 10 steroid-dependent asthmatic patients. The forced expiratory volume in 1 second (FEV1) and the respiratory resistance (Rrs) were measured 1, 2, and 3 hours after oral administration of 200 mg DG-5128 and compared with the premedication measurements. Two hours after DG-5128 administration, the FEV1 rose significantly (p less than 0.01) and the Rrs decreased significantly (p less than 0.05). Asthmatic symptoms (cough, wheezing, dyspnea) also improved in 80% of the patients. This finding raises the possibility that alpha-2 adrenoceptors exist in human airways, that they play an important role in the pathophysiology of asthma, and that the overfunction of these alpha-2 adrenoceptors and/or Gi-protein cause intractable asthma.
J Asthma 1988
PMID:Inhibitory effect of DG-5128 on steroid-dependent asthma. 290 33


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