Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The influence of replacing the phenolic hydroxyl by the methoxy group on opioid receptor binding, analgesic and antitussive action was investigated in the corresponding couples morphine-codeine, hydromorphone-hydrocodone and O-desmethyltramadol (L 235)-tramadol. Binding was studied on rat whole brain membranes (without cerebellum) with the radioligands dihydromorphine (mu-site), ethylketocyclazocine (k-site), D-Ala2-D-Leu5-enkephalin (delta-site) and naloxone (no selective binding). Analgesia (tail flick) and antitussive action (NH3-vapour induced cough) was investigated in rats and ED50 values 10 min after i.v. application were calculated to compare efficacy. All free hydroxyl compounds had higher opioid receptor affinities than the corresponding methoxy derivatives and were more active at the mu-site. The methoxy derivatives codeine and tramadol only had low affinities lacking selectivity towards mu-, kappa-, or delta-binding. Hydrocodone in contrast showed strong and mu-selective binding. The hydroxy compounds had higher analgesic activity than the methoxy congeners and analgesia appeared to correlate with mu-binding affinity. Codeine and hydrocodone were weaker antitussives than the corresponding hydroxy compounds, whereas no significant difference was found between O-desmethyltramadol and tramadol. Only in the tramadol group the methoxy substitution increased antitussive potency in relation to analgesic potency.
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PMID:Receptor binding, analgesic and antitussive potency of tramadol and other selected opioids. 284 50

Previous studies have reported increased occurrence of respiratory and sensory irritation symptoms among residents living close to biodegradable waste sites. However, few studies have been able to quantify direct and annoyance-mediated effects based on individual-specific assessments of chemical exposures. We examined associations between residential exposures to a proxy gas (ammonia, NH3) from biodegradable wastes (mainly from farming, animal and agricultural activities) and odor annoyance and six respiratory and sensory irritation symptoms (self-reported), using adjusted logistic regression models and mediation analyses. Individual-specific NH3 exposures (n=454) in residential environments during 2005-2010 were calculated by the Danish Eulerian long-range transport model and the local-scale transport deposition model. Residential NH3 exposure was associated with increased frequency of four symptoms, including "eyes itching, dryness or irritation" and "cough" (ORadj=1.69; 95% CI: 1.09-2.61 and ORadj=1.75; 95% CI: 1.12-2.74, for each unit increase in loge(NH3 exposure)). Odor annoyance mediated the effect of exposure on cough and three sensory irritation symptoms. Mediation was either full (indirect-only effects) or partial (direct and indirect effects). This study provides support for the existence of indirect associations between residential exposures to low-to-moderate air pollution from wastes and symptoms, as well as direct dose-response associations for some of the symptoms.
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PMID:Respiratory and sensory irritation symptoms among residents exposed to low-to-moderate air pollution from biodegradable wastes. 2473 1