Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 52-year-old female was referred to our department for treatment of a left lung tumor, 80 mm in diameter, arising in the left S1 + 2. The patient's chief complaint was persistent dry cough and spiking fever. Left upper lobectomy with hilar and mediastinal lymph node dissection (ND2a) was performed, and the pathological diagnosis was primary large cell carcinoma of the lung, p-T3N0M0. At one week after being discharged, the patient visited our outpatient clinic complaining of a sore throat. A tumor in the right tonsil was discovered, and excisional biopsy revealed it to be metastasis from the large cell carcinoma of the lung. Right cervical lymph node metastasis was also detected, and the patient was treated by combined chemo-radiotherapy, resulting in a complete remission.
Jpn J Thorac Cardiovasc Surg 2001 Jun
PMID:Tonsillar metastasis from large cell carcinoma of the lung. 1148 42

Here, we present a case report on a young female patient with a carinal leiomyoma. The patient complained of progressive dyspnea and paroxysmal cough. The laminagram and bronchoscopy revealed a lobulated carinal tumor, and carinal resection and reconstruction were performed. In this report, we will emphasize the appropriate surgical treatment for this condition.
Thorac Cardiovasc Surg 2001 Aug
PMID:Carinal leiomyoma: report of a case treated by carinal resection and reconstruction. 1150 22

Intrapericardial teratoma was diagnosed in a nine-year-old male infant with a three-month history of labored breathing and cough. The tumor was completely resected and found to be a mature teratoma, containing pancreatic tissue and producing insulin. A few glucagon and somatostatin containing cells were also present in the periphery of the islets. Postoperative course was uneventful. This is to our knowledge, the first report of an intrapericardial teratoma with such endocrine activity.
J Cardiovasc Surg (Torino) 2001 Dec
PMID:An intrapericardial teratoma with endocrine function. 1169 46

We report successful repair of a ruptured chronic aortic dissection in a 63-year-old female who had undergone end-to-end anastomosis for acute type A dissection 8 years before. The patient had hypotension with back pain and cough. A computed tomogram revealed a large chronic aortic dissection (Stanford type A) and complete atelectasis of the left lung due to hemothorax. The brachiocephalic artery was also dissected and aneurysmal. Emergency surgery was performed. Subtotal thoracic aortic replacement with reconstruction of 4 cervical vessels was carried out using hypothermic circulatory arrest with selective cerebral perfusion via a redo-sternotomy and a left anterolateral thoracotomy. The patient was discharged from the hospital without any sequelae.
Ann Thorac Cardiovasc Surg 2001 Oct
PMID:Subtotal thoracic aortic replacement as reoperation for ruptured aortic dissection: report of a case. 1174 63

In a rare case of bronchogenic cyst with high carbohydrate antigen (CA) 19-9 production, a 57-year-old man with coughing and chest pain was diagnosed with a subcarinal mediastinal tumor. Fiberoptic bronchoscopy showed an erosive mucosal lesion overlying the area of extrinsic compression at the membranous of the right mainstem bronchus. Serum carbohydrate antigen 19-9 was elevated at 1300 U/ml. Thoracotomy showed an encapsulated cyst tightly adhering to the right main bronchus. The cyst was extirpated after ablation at the adherent cystic wall by electrocautery. Although intracystic carbohydrate antigen 19-9 concentration was very high, serum carbohydrate antigen 19-9 and bronchoscopic findings returned to normal postoperatively. The histological diagnosis was consistent with a bronchogenic cyst and carbohydrate antigen 19-9 could be immunohistochemically demonstrated within its epithelium.
Jpn J Thorac Cardiovasc Surg 2002 Jan
PMID:Subcarinal bronchogenic cyst with high carbohydrate antigen 19-9 production. 1185 1

A 52-year-old woman with a 3-week history of fever and cough was diagnosed as having bacterial endocarditis with vegetation and severe mitral valve insufficiency by echocardiography. Blood culture revealed Streptococcus mitis. After antibiotic treatment for 3 weeks, the patient noticed swelling with pain in her left groin. Computed tomography revealed an occluded aneurysm in the left common femoral artery. Simultaneous surgical treatments of mitral valve replacement and bypass grafting using a saphenous vein following resection of the mycotic femoral arterial aneurysm were performed. Pathohistological examination of surgical specimens revealed acute inflammatory findings, but no microorganisms were found, probably because of the preoperative antibiotic therapy. Her postoperative course was uneventful, and there was no recurrence of mycotic aneurysms in a period of 10 months after the operation. Prompt recognition and urgent simultaneous surgical treatments for mycotic aneurysms complicated with infective endocarditis were effective.
Ann Thorac Cardiovasc Surg 2001 Dec
PMID:Simultaneous mitral valve replacement and bypass grafting for mycotic aneurysm of the femoral artery during the active phase of infective endocarditis: a case report. 1188 81

A 57-year-old Caucasian woman presented with nonproductive cough. Computed tomography revealed a peripheral solid mass in the upper lobe of the left lung. She underwent thoracotomy and upper lobectomy. Histology of the excised tumor demonstrated lymphoepithelioma-like carcinoma of the lung, with no associated Epstein-Barr virus activity. Being a rare entity and mostly seen in Asians, very few cases have been described previously.
Asian Cardiovasc Thorac Ann 2002 Jun
PMID:Primary lymphoepithelioma-like carcinoma of lung. 1207 53

Heart failure is a common and often debilitating condition, but one for which there exists a variety of effective pharmacological therapies. The angiotensin converting enzyme (ACE) inhibitors represent one of the mainstays of the treatment of heart failure. In spite of a wealth of evidence regarding the efficacy of these agents in improving mortality and morbidity in heart failure, they are often under-utilised. Failure to prescribe or to prematurely withdraw ACE inhibitor therapy often stems from physicians perceptions regarding the likelihood of unwanted effects, in particular hypotension, renal impairment and cough. The evidence from clinical trials is that these unwanted effects are relatively uncommon. In routine clinical practice the rate of prescription of ACE inhibitor therapy is related to the expertise and motivation of the physician. There is a need for education of all health care professionals involved in the care of patients with heart failure with regard to the maximisation of ACE inhibitor therapy in heart failure.
Cardiovasc Drugs Ther 2002 Jan
PMID:Angiotensin converting enzyme inhibition in heart failure: clinical trials and clinical practice. 1208 81

We report 2 cases diagnosed as so-called pulmonary inflammatory pseudotumor. In case 1, a 28-year-old man with a slow growing 6-cm pulmonary tumor who underwent a right upper lobectomy was diagnosed with an inflammatory myofibroblastic tumor. In case 2, a 55-year-old man with chest pain and cough, who underwent open lung biopsy was diagnosed with plasma cell granuloma. Despite both diagnoses being classified as pulmonary inflammatory pseudotumors, we believe they should be classified differently.
Jpn J Thorac Cardiovasc Surg 2002 Jul
PMID:Surgically treated pulmonary inflammatory pseudotumor. 1216 72

Imidapril hydrochloride (imidapril) is a long-acting, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor, which has been used clinically in the treatment of hypertension, chronic congestive heart failure (CHF), acute myocardial infarction (AMI), and diabetic nephropathy. It has the unique advantage over other ACE inhibitors in causing a lower incidence of dry cough. After oral administration, imidapril is rapidly converted in the liver to its active metabolite imidaprilat. The plasma levels of imidaprilat gradually increase in proportion to the dose, and decline slowly. The time to reach the maximum plasma concentration (T(max)) is 2.0 h for imidapril and 9.3 h for imidaprilat. The elimination half-lives (t(1/2)) of imidapril and imidaprilat is 1.7 and 14.8 h, respectively. Imidapril and its metabolites are excreted chiefly in the urine. As an ACE inhibitor, imidaprilat is as potent as enalaprilat, an active metabolite of enalapril, and about twice as potent as captopril. In patients with hypertension, blood pressure was still decreased at 24 h after imidapril administration. The antihypertensive effect of imidapril was dose-dependent. The maximal reduction of blood pressure and plasma ACE was achieved with imidapril, 10 mg once daily, and the additional effect was not prominent with higher doses. When administered to patients with AMI, imidapril improved left ventricular ejection fraction and reduced plasma brain natriuretic peptide (BNP) levels. In patients with mild-to-moderate CHF [New York Heart Association (NYHA) functional class II-III], imidapril increased exercise time and physical working capacity and decreased plasma atrial natriuretic peptide (ANP) and BNP levels in a dose-related manner. In patients with diabetic nephropathy, imidapril decreased urinary albumin excretion. Interestingly, imidapril improved asymptomatic dysphagia in patients with a history of stroke. In the same patients it increased serum substance P levels, while the angiotensin II receptor antagonist losartan was ineffective. These studies indicate that imidapril is a versatile ACE inhibitor. In addition to its effectiveness in the treatment of hypertension, CHF, and AMI, imidapril has beneficial effects in the treatment of diabetic nephropathy and asymptomatic dysphagia. Good tissue penetration and inhibition of tissue ACE by imidapril contributes to its effectiveness in preventing cardiovascular complications of hypertension. The major advantages of imidapril are its activity in the treatment of various cardiovascular diseases and lower incidence of cough compared with some of the older ACE inhibitors.
Cardiovasc Drug Rev 2002
PMID:Protection of the cardiovascular system by imidapril, a versatile angiotensin-converting enzyme inhibitor. 1217 88


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