Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This was a double-blind, randomised evaluation of the efficacy and safety of Zaditen in comparison with placebo in infants and young children (aged 6-36 months). These children either had (i) at least 2 episodes of wheezing over 8 weeks, or (ii) persistent wheeze over 4 weeks, prior to entering into the study. In the doctor's opinion, the group treated with Zaditen had more improvement in symptomatology (p < 0.05). They were more likely to have reduced or discontinued bronchodilators. They showed trends of improvement of symptom scores in night cough, wheeze and sputum production. These differences, however, did not reach statistical significance. There were no major adverse reaction of note.
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PMID:Efficacy of Zaditen (ketotifen) in wheezy infants and young children. 130 70

In a double-blind study we compared the effect of 2 mg ketotifen (Zaditen) daily and 1050 mg aminophylline daily for 6 months in two groups of altogether 24 patients with bronchial asthma and a chronic obstruction of the airways. Lung function tests were done in regular intervals to investigate the effects of the drugs on the central airways resistance, thoracic gas volume, forced expiratory volume of the first second and inspiratory vital capacity--and the peripheral airways closing volume, flow of iso and the flow volume curve. Ketotifen reduced the obstruction of the central and of the peripheral airways. Aminophylline showed a less pronounced effect on the obstruction of the central airways and did not influence the peripheral airways. Number and severity of asthmatic attacks, cough, dyspnea and expectoration improved with both drugs. From our results we conclude that ketotifen reduces the obstruction of the central airways and also may exert a direct influence on the small airways. This drug therefore seems to possess special antiasthmatic effects. In contrast aminophylline acts as a rapidly effective bronchodilating agent with no detectable effects on the peripheral airways.
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PMID:The influence of ketotifen and aminophylline on the central and peripheral airways. 668 68