Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Non Hodgkin's lymphoma (LNH) presenting as a localised tumour is exceptional and nearly always appears during the course of disseminated disease. We report a case where the primary disease was an endobronchial tumour and the entire clinical picture related to pulmonary symptoms. A 70 year old lady was found to have a left sided pulmonary opacity following a cough with minimal expectoration and accompanied by chest pains and dyspnoea. The chest abnormality progressed for 3 years 9 months before an endobronchial tumour was discovered at bronchoscopy in the left upper lobe and from which a biopsy revealed an LNH with small cells of low degree of malignancy. In addition there was splenomegaly and an infiltration of bone marrow by the lymphomatous process which was evidence of a disseminated form of LNH. To our knowledge our observation is an extremely rare case where an endobronchial tumour revealed a non Hodgkins lymphoma.
Rev Mal Respir 1991
PMID:[Non-Hodgkin's lymphoma disclosed by an intrabronchial tumor. Apropos of a case]. 192 78

The authors present a clinical case pertinent to a patient suffering from persistent dry cough and dyspnea by effort. It is described the diagnostic course that enables to identify a diffuse pulmonary microlithiasis, of rare cheeking, whose pathogenetic hypotheses and differential problems are tackled.
Arch Monaldi Mal Torace
PMID:[Diffuse pulmonary microlithiasis (a clinical case)]. 215 31

The pulmonary primary localization of the histiocytosis X is rather rare. We describe here a case of histiocytosis X with a localization exclusively at pulmonary level in a 38 years old young man who is a heavy smoker. A dry cough, asthenia and an increasing dyspnoea were the first symptoms of the disease. The radiological picture showed a widespread pulmonary intersticepathy. The diagnosis has been obtained testing some fragments of the pulmonary parenchyma taken through a diagnostic thoracotomy with an electron microscope.
Arch Monaldi Mal Torace
PMID:[A case of primary pulmonary histiocytosis X]. 215 51

From December 1986 to January 1988, 100 General Practitioners and Pneumologists working outside hospital included in open unmatched series 275 patients who were diagnosed as having pneumonia at home. The study consisted of 53.2% men with an average age of 49.3 plus or minus 19.3. Their temperature on the first day (J1) was in 72.7% of cases greater than 38.5 degrees Centigrade. The doctors felt that the general state was good in 66.5% of the cases. Cough was present in 83.5% of cases but was dry in one out of every two. The patients received Amoxycillin in a dose of 2 grams per day orally (66.9%), or by injection (33.1%). On the third day (J3) 90% of the patients had a temperature below 38.5 degrees Centigrade. Their general state was improved in 94.6% of cases. The diagnosis of pneumonia at home was confirmed radiologically on 219 of the films available, confirming the good specificity of the clinical diagnosis of pneumonia at home. Ten patients were hospitalised. The apparent treatment of Amoxycillin was given in 247 cases (89.8% of cases). In 28 cases (10.2%) the treatment was changed by the addition or substitution of a Macrolide (15), or another antibiotic (5), and in 80 cases a change of treatment was not specified. 25 of these 28 cases were reviewed on the 14th day (J14) and no failures were observed after the change of treatment. In 247 patients in whom the treatment with Amoxycillin was followed 336 were reviewed on the 15th day and there had been four failures. Three were intolerant to the drug and there was one relapse.(ABSTRACT TRUNCATED AT 250 WORDS)
Rev Mal Respir 1990
PMID:[Amoxicillin as a 1st choice: 275 acute focal pneumopathies treated on an outpatient basis]. 218 69

Today heart-lung transplantation (HLT) probably provides the best means of studying the role of pulmonary innervation in human respiratory physiology. Outside the periods of postoperative complications ventilatory function, blood gases and exercise tolerance of HLT recipients are compatible with a normal sedentary life. Control of breathing in the waking state at rest, and when asleep, in HLT subject is not different from that of the healthy subject, which suggests that the pulmonary afferents play a negligible role in the control of breathing of adult humans at rest. The results of the ventilatory response to carbon dioxide and to exercise in HLT subjects are contradictory and do not enable any conclusion about the role of pulmonary innervation in these types of integrated responses. On the other hand, the existence of bronchial hyperreactivity to cholinergic stimulation is well established, and is attributed to an upregulation of bronchial muscarinic receptors. An increase in the bronchial response to distilled water observed in some HLT subjects seems on the other and related to episodes of lung rejection. The reflex theory of cough is supported by studies of HLT subjects. Results of studies of the effect of a deep inspiration on bronchomotor tone are far from concordant. Other studies including a large number of subjects and looking at the presence or the absence of reinnervation after transplantation are perhaps two supplementary means to further investigate the respiratory function of HLT patients. Knowledge of the latter would equally enable a better understanding of control mechanisms of human respiratory physiology.
Rev Mal Respir 1990
PMID:[Respiratory function in cardiopulmonary transplantation]. 220 69

We study the hemodynamic effects of pressotherapy in 11 patients (mean age : 68 +/- 10 years) with uncomplicated acute myocardial infarction (n = 6) or with chronic ischemic heart failure (n = 5). We measure the right auricular pressure (RAP), the mean pulmonary arterial pressure (MPAP) and the pulmonary wedge pressure (PWP), before, during pressotherapy (MPAP) and the pulmonary wedge pressure (PWP), before, during pressotherapy (T 20 min) and 30 minutes after the end of pressotherapy (T 30 min). We use five-chambered leg garments with 80 mm Hg pressure during 20 minutes. The wavelike action (from the bottom to the top) is intermittent: the compression time is 10 second (sec); compression is maintained during 60 sec; deflation time is 15 sec. After 20 minutes pressotherapy (t 20) the 3 variables increase: RAP: from 3.6 +/- 5 to 7 +/- 7 mm Hg (P less than 0.001), MPAP: from 25 +/- 14 to 29 +/- 17 mm Hg (p less than 0.01) and the PWP from 10 +/- 8 to 17 +/- 11 Hg (p less than 0.01). This rise is particularly important in heart failure patients: from 18 +/- 8 to 29 +/- 8 mm Hg for the PWP, with cough in one patient. At T 30 these 3 variables decrease and return nearly to initial values: respectively 2.7 +/- 4.7 (RAP), 24 +/- 14 (MPAP), 12 +/- 8 mm Hg (PWP). In conclusion pressotherapy increases RAP and pulmonary pressures.(ABSTRACT TRUNCATED AT 250 WORDS)
J Mal Vasc 1990
PMID:[Hemodynamic impact of pressotherapy]. 221 70

This is a case report of a 39 year old patient in whom histiocytosis X was discovered following a cough which had appeared several months before. The radiological investigations were distinctive immediately associating the alveolar lesions and the excavated macronodules. The clinical examination was normal but there were some laboratory features suggesting inflammation. The diagnosis was achieved following a surgical biopsy which on histological examination showed histiocytic granulomas and the immunology revealed cells which were positive for OK T6 monoclonal antibodies and S100 antiprotein antibodies. There was subsequently a spontaneous regression with disappearance of the nodular shadows only leaving a few cystic forms. This observation is distinctive and is characterised by the rare appearance of the initial radiology and also confirms the predisposing factor of smoking in the pathogenesis of histiocytosis X.
Rev Mal Respir 1990
PMID:[Histiocytosis X: excavated macronodular form. Initial alveolar phase with spontaneous regression. Role of smoking]. 227 Mar 49

We report a case of a 62 year old man who presented with effort dyspnoea accompanied by a cough and haemoptysis. The chest radiograph of the thorax showed atelectasis of the right upper lobe. Bronchoscopy showed evidence of a tumour like mass obstructing the right bronchus and this revealed itself to be a mass of organised fibrinous deposit in granulation tissue containing numerous colonies of Aspergillus. In fact it appeared to be an obstructive Aspergillus bronchitis, with a pseudo-tumour appearance attached to a carcinoid tumour which was obstructing the apical segment of the right upper lobe. Obstructive Aspergillus bronchitis makes up only a small percentage of overall respiratory disease caused by Aspergillus. They pose a problem of differential diagnosis with bronchopulmonary aspergillosis which is much more frequent.
Rev Mal Respir 1990
PMID:[Endobronchial aspergillosis associated with a carcinoid tumor]. 227 Mar 53

Angiotensin-converting enzyme inhibitors (ACEI) constitute an effective and well tolerated class of drugs for the treatment of arterial hypertension. Yet they have been blamed for the occurrence of side-effects the most frequently reported of which are renal function impairment, hypotension and cough. For this reason, the renal function of hypertensive patients has been evaluated after short - and long - term treatment with perindopril. In patients with normal renal function on short-term treatment (1 and 5 days) perindopril produced an increase of renal plasma flow without change in glomerular filtration. In long-term treatment (up to 18 months), no significant change in plasma creatinine level was observed. In old age hypertensive patients or in patients with chronic renal failure glomerular filtration was also preserved, apart from rare cases of creatinine clearance reduction, notably after addition of hydrochlorothiazide. A very slight and clinically not significant rise of kaliemia was noted when perindopril was used as single-drug treatment. Cases of symptomatic hypotension were rare (0.2 p. 100), even in situations of water and salt depletion. Among the other side-effects of ACEI, cough, which has more recently been described, has carefully been looked for. Its incidence has been determined in a double-blind trial comparing perindopril (1.2 p. 100) with captopril (2.4 p. 100). It has also been evaluated in a long-term study involving 632 hypertensive patients, 391 of whom were treated for 1 year; its incidence then was 2.9 p. 100, and drug withdrawal was required in 8 cases.(ABSTRACT TRUNCATED AT 250 WORDS)
Arch Mal Coeur Vaiss 1989 May
PMID:[Tolerance and safety of the use of perindopril]. 250 18

The respective prevalence of arterial hypertension and of asthma is sufficient that their association is far from unusual. Antihypertensive medications may have deleterious or beneficial effects on the bronchi. Calcium inhibitors oppose the contraction of smooth muscle and the liberation of inflammatory mediators from mast cells. In asthmatics, their acute administration has a modest beneficial effect on spontaneous bronchial obstruction, only exerts a partial protective action against numerous non-specific or allergic stimuli, and weakly reinforces the beneficial effects of beta-2 agonists. The antagonists of beta-adrenergic receptors worsen bronchial obstruction and non-specific bronchial hyperreactivity in asthmatics. These deleterious effects increase with the dose and have been observed even after administration of eye drops and apply to all beta blockers. Inhibitors of angiotensin converting enzymes increase bronchial hyperreactivity in patients developing cough during treatment and may indeed, even in a few cases, trigger an asthmatic attack, probably by opposing the inactivation by hydrolysis of tachykinins and bradykinins. The effects of alpha-2 adrenergics are controversial. Inhaled, they reduce the early allergic bronchial response, even when ingested they aggravate the bronchial response to histamine, all the more so as their effect on the central nervous system is greater. The alpha-1 adrenergic antagonists, frusemide and ketanserin have an overall beneficial effect.
Rev Mal Respir 1989
PMID:[Asthma and antihypertensive treatment]. 267 23


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