Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The therapeutic value of adding a slow-release theophylline product (Theo-Dur) to the regular treatment program consisting of beta-stimulants and steroids was evaluated in 31 adult asthmatics. Theophylline in a dose of 300 mg or placebo was administered twice daily during two 14-day periods in a randomized double-blind cross-over study. PEF and asthma symptoms were recorded daily. In the morning, 12 h after tablet intake, spirometry was performed and the theophylline concentration determined. The addition of theophylline slightly, but statistically significantly, increased the daily PEF values and reduced dyspnoea, but not cough, sputum volumes and aerosol consumption. The patients showed preference for the combined treatment. Spirometry at the end of each period did not differ significantly between treatments. The mean theophylline concentration in the morning 12 h after tablet intake was 39 mumol/l (range 15-81 mumol/l). The results of the study suggest that the addition of a slow-release theophylline preparation to beta-stimulant therapy provides further relief of asthma symptoms without an unacceptable increase in the incidence of side-effects.
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PMID:Combined theophylline/beta-agonists maintenance therapy in chronic asthma. 613 32

Twenty-one patients, suffering from bronchial asthma, with a moderate and clearly reversible airway obstruction, completed a double-blind cross-over trial of two theophylline sustained-release preparations, Theolair Retard (= Theolair S.R. = Nuelin S.R.) and Theolin Retard (= Theo-Dur). The serum theophylline concentration curves of Theolin Retard were significantly flatter than the curves of Theolair Retard, with less peak-trough variation. Pulmonary function in both treatment groups appeared to be the same. There were no differences in side effects, nor in asthma symptoms. However, patients complained significantly more of coughing during treatment with Theolin Retard. In two patients using antacids, the peak-trough variation with Theolair Retard was considerably larger than average. The favourable theophylline concentration profile of Theolin Retard is not reflected in pulmonary function, side effects or asthma symptoms. For this group of asthmatic hospitalized inpatients the practical differences between the two preparations are not distinctive.
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PMID:A double-blind comparative trial between two sustained-release theophylline preparations with individual doses in asthmatic in-patients. 676 Jan 11

An efficient method combining SEP-PAK C18 cartridge solid phase extraction (SPE) with reversed-phase high performance liquid chromatography for the quantitation of morphine in the Compound Liquorice Tablet is presented. The tablets have been used for making expectoration easy and relieving cough for years. The tablet powder (approximately 1 tablet) was added into a stoppered centrifuge tube, and vertically extracted with 5 mL of 0.5% HAc for 5 min. After centrifugation the supernatant was transferred to a beaker and the extraction was repeated twice with 4 mL and then 3 mL of 0.5% HAc. Five millilitres of carbonate buffer (pH 8.9) was added to the combined extracts. A SEP-PAK C18 cartridge was pretreated by passing methanol and distilled water, using a glass syringe. The mixture was applied on it and allowed to flow through. The cartridge was washed first with 5 mL of 10% methanol solution and then the morphine was eluted with 4 mL of 70% methanol solution into a 5 mL volumetric flask and was finally diluted to volume with 70% methanol solution. Analysis was performed on a mu-Bondapak C18 column(300 mm x 4.6 mm i.d., 10 microns) with 0.1 mol/L NaH2PO4-methanol(5:1) as the mobile phase and detection at 286 nm. The average recovery of morphine was (101.2 +/- 1.5)% and RSD was 1.5%. The method is simple, rapid, accurate, and reproducible, and can be used in drug control.
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PMID:[Determination of morphine in compound liquorice tablets by high performance liquid chromatography with SEP-PAK C18 cartridge pretreatment]. 1132 1

Liquorice is a very ancient plant widely used in the East for millennia. It has often been employed in sweets and confectionery and also for minor ailments including cough, constipation and dyspepsia. It was probably carried to Europe by the Cluniac order of monks. Then, almost by accident, it became established in West Yorkshire at Pontefract after the dissolution of the monasteries in the 1530s. Abuse of liquorice is not uncommon. It can occur in the anorexia/bulimia syndrome and also in the dangerous condition of pseudoaldosteronism, which is characterised by severe hypertension and hypokalaemia and can lead to death. Liquorice remains a useful sweetener for all sorts of confectionery, including sweets and cakes (together with beer and liqueurs).
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PMID:Liquorice (Glycyrrhiza glabra): the journey of the sweet root from Mesopotamia to England. 3118 55