Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Most cases of blastomycosis are sporadic and only nine outbreaks representing a total of 112 cases have previously been reported. Less than half of these have been culture proven cases. Outbreaks have previously occurred in North Carolina, Minnesota, Illinois, Wisconsin and Virginia. We report three culturally confirmed cases of blastomycosis from Elizabethton, Tennessee, who had onset of illness within a one-week span of time. The patients presented with fever, chest pain, weight loss, poor appetite and myalgia. Each initially had a dry cough which became productive of purulent sputum as the illness progressed. Mild hemoptysis occurred during each patient's course. Serologic testing by immunodiffusion and enzyme immunoassay were positive and testing by complement fixation was negative in each case. The diagnosis was made by histopathology on transbronchial biopsy or transthoracic needle aspiration material. Each patient improved on ketoconazole therapy.
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PMID:An outbreak of blastomycosis in eastern Tennessee. 176 58

The author reports the observations over 190 patients referred to the Tuberculosis Institute for the present or suspected pulmonary tuberculosis of the lower lobe localization. In 47 (24.7%) of the patients the diagnosis of tuberculosis was rejected and lung cancer was diagnosed, central--in 5 of them, peripheral--in 42. Clinical manifestations in patients with tuberculosis and cancer were similar, weakness, cough, poor appetite being predominent; however, in cancer patients these were more frequently observed and more manifest with a tendency to aggravation and showing no response to tuberculostatic drugs. In 26.6% of patients with pulmonary tuberculosis and in 21.3% of lung cancer patients clinical manifestations of the disease were either entirely absent or insignificantly pronounced.
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PMID:[Differential diagnosis of inferior lobe tuberculosis and malignant lung tumors]. 735 92

A 41-year-old man who had tested positive for HIV infection presented with cough, yellow sputum, fever, and chills of 10 days' duration. He was short of breath at rest and had a poor appetite. He did not have chest pain, bloody sputum, or weight loss.
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PMID:Unusual pathogen in a man with HIV infection. 900 80

A 52-year-old man presented with a four-month history of malaise, low-grade fever, decreased appetite, and a 20-pound weight loss. He complained of joint pain and swelling, proximal muscle weakness, exertional dyspnea, and a dry cough. He also noted that his fingers had turned white and then blue when chilled and red when rewarmed. He had not had pleuritic chest pain, dysphagia, dry eyes or mouth, rash, or skin photosensitivity.
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PMID:A man with vague rheumatic complaints. 975 May 51

A 40-year-old man presented with a three-week history of malaise, nausea, night sweats, decreased appetite, and a 15-lb weight loss. He reported having had diarrhea, occasionally with bright red blood, for the first two weeks and a temperature as high as 39.4 degrees C for the last two weeks. He had not had cough, shortness of breath, wheezing, chest pain, arthralgias, rash, or conjunctivitis. He had not eaten raw oysters or raspberries.
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PMID:A man with fever and lymphadenopathy. 982 54

An 18-year-old male presented with a 2-day history of left-side anterior chest pain. The pain was intermittent, crampy, and worsened with exertion. Associated symptoms were cough with sputum, night sweats, fever, decreased appetite, and 4.5-kg weight loss; cavitary lesions were seen on chest radiograph. The patient also had significant dental caries. Nasal biopsy revealed findings consistent with Wegener's granulomatosis. Combined treatment with cyclophosphamide and prednisone significantly improved his symptoms over the long term.
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PMID:Chest Pain, Cough, and Hemoptysis. 1035 79

Allergic rhinitis (AR) is rarely found in isolation and needs to be considered in the context of systemic allergic disease associated with numerous comorbid disorders, including asthma, chronic middle ear effusions, sinusitis, lymphoid hypertrophy with obstructive sleep apnea, disordered sleep, and consequent behavioral and educational effects. The coexistence of AR and asthma is complex. First, the diagnosis of asthma may be confounded by symptoms of cough caused by rhinitis and postnasal drip. This may lead to either inaccurate diagnosis of asthma or inappropriate assessment of asthma severity with over treatment of the patient. The term "cough variant rhinitis" is therefore proposed to describe rhinitis that manifests itself primarily as cough that results from postnasal drip. AR, however, also has a causal role in asthma; it appears both to be responsible for exacerbating asthma and to have a role in its pathogenesis. Postnasal drip with nasopharyngeal inflammation leads to a number of other conditions. Thus sinusitis is a frequent extension of rhinitis and is one of the most frequently missed diagnoses in children. Allergen exposure in the nasopharynx with release of histamine and other mediators can cause Eustachian tube obstruction possibly leading to middle ear effusions. Chronic allergic inflammation of the upper airway causes lymphoid hypertrophy with prominence of adenoidal and tonsillar tissue. This may be associated with poor appetite, poor growth, and obstructive sleep apnea. AR is therefore part of a spectrum of allergic disorders that can profoundly affect the well being and quality of life of a child. Prospective cohort studies are required to assess the disease burden caused by AR in childhood and to further assess the potential educational impairment that may result. Because AR is part of a systemic disease process, its management requires a coordinated approach rather than a fragmented, organ-based approach.
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PMID:Pediatric allergic rhinitis and comorbid disorders. 1144 1

The overall prevalence rate of Cephalopina titillator in 778 slaughtered camels was 71.7%, 55% in males and 85% in females. The mean larval counts in infested camels were 26.7 +/- 25.9 and 34.6 +/- 30.8, for males and females, respectively. There were highly significant differences (p < 0.001) in the number of larvae in camels of different ages and sexes and also between the wet and dry seasons. The average time to pupate was 4.9 +/- 4.6 minutes, and the pupation period was 21 +/- 2.4 days. The major gross lesions observed were congestion of the pharyngeal mucosa with profuse secretions, and haemorrhage in early cases. In some cases, there were ulcer-like lesions and nodules, which contained pus. The dominant microscopic lesions were infiltration of the lamina propria by eosinophils, lymphocytes and macrophages, hyperplasia of the stratified squamous epithelium, necrotic changes in the mixed glands and desquamation of epithelial cells. A survey using questionnaires revealed that all the camel owners called the disease caused by infestation with C. titillator 'Sengale' and that 87% of them considered that infestation with these larvae results in reduced milk production and body weight. The major clinical signs of the disease were sneezing and expulsion of larvae (68%), abnormal movement of the head (45%), grooming (44%), nasal discharge (40%), poor appetite (26.7%), difficulty in breathing (18%), and sometimes bleeding from the nostrils (18%) and coughing (27%).
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PMID:Studies on Cephalopina titillator, the cause of 'Sengale' in camels (Camelus dromedarius) in semi-arid areas of Somali State, Ethiopia. 1177 Feb 3

A 80-year-old male visited an outpatient department of a nearby hospital complaining of fever, cough, and poor appetite on June 2000. The patient was diagnosed as bacterial pneumonia and was treated with antibiotics although specific cause could not be identified. After one month, he was hospitalized due to lack of improvement. After admission, acid-fast bacilli (AFB) was found from the bronchial washing. The patient was then transferred to our hospital. Upon admission, sputum smear examination was positive for AFB and MTB was confirmed by PCR. Therapy was initiated with INH 300 mg, RFP 450 mg, EB 1000 mg, and PZA 1000 mg, orally daily. However, on the day following the admission, he became unconscious. Brain MRI showed several small granulomas on the cortex of the bilateral anterior and temporal brain. Although AFB was not detected from the cerebrospinal fluid, tuberculous meningitis was suspected and steroid was given. Nine days after admission, the patient died due to tuberculous meningitis. The isolation of MTB had been attempted on Ogawa culture medium using patient's sputum and liquor, and it took 14 weeks to find colony growth both from sputum and liquor. In the autopsy, numerous granulomas were detected in his lung, liver, kidney, and pancreas. These findings indicate that disseminated growth of MTB occurred in vivo in spite of very slow growth of MTB in vitro.
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PMID:[A case of disseminated tuberculosis requiring extended period for the identification of Mycobacterium tuberculosis on culture]. 1190 31

In a densely populated urban area of Karachi, Pakistan, a questionnaire survey was made of the knowledge and practices of 120 private general practitioners about the diagnosis and treatment of tuberculosis (TB). The majority knew that cough, fever and weight loss were the main symptoms of TB, but less than half knew that blood in sputum, poor appetite and chest pain were associated with the disease. Only 58.3% of physicians used sputum microscopy for diagnosing TB and 35.0% used it as a follow-up test. Only 41.7% treated TB patients themselves, the remaining referring their patients to specialists. Around 73.3% of the doctors were aware of the 4 first-line anti-TB drugs. Efforts to improve the knowledge of private practitioners, and strategies to enhance public-private collaboration forTB control in urban areas are urgently required.
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PMID:Tuberculosis diagnosis and treatment practices of private physicians in Karachi, Pakistan. 1574 73


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