Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It has been suggested that the apparent relationship between children's cigarette smoking and their respiratory symptoms could be explained by the effect of parents' smoking upon both child's smoking and symptoms. This was investigated in a study of 6000 Derbyshire schoolchildren. Children who smoked regularly were more likely than nonsmokers to report cough first thing in the morning, cough at other times during the day or at night, and breathlessness. Children whose parents smoked were also more likely to report these symptoms than were the children of nonsmokers. Both the child's and parents' smoking were independently related to the child's respiratory symptoms. Morning cough was less prevalent than cough at other times during the day or at night, but the relationship between the child's smoking and morning cough was much closer than its relationship to cough at other times. The relationship between parents' smoking and the child's symptoms was similar for each symptom.
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PMID:Effect of children's and parents' smoking on respiratory symptoms. 64 12

A respiratory-occupational questionnaire and spirometry were used to compare the prevalence of symptoms and pulmonary function abnormalities in 405 workers exposed to red cedar dust and 252 control workers exposed to other wood dusts. Compared with controls, the cedar workers were found to have a significantly higher prevalence of respiratory symptoms, cough, phlegm, wheeze and breathlessness, as well as more rhinitis and conjunctivitis. While, as expected, there was a clear relationship between respiratory symptoms and cigarette smoking, there was also evidence to suggest a synergistic effect between exposure to cedar dust and smoking. There was no difference in the lung function between cedar workers and controls. Sixty-five workers in the control group previously had worked in red cedar mills; they had a higher prevalence of respiratory symptoms than other workers in this group. Red cedar asthma was found in only 1.1% of the cedar workers. This condition usually develops in the early months of exposure, and workers who are affected tend to leave the industry. The probable incidence of red cedar asthma was estimated to be higher, around 4-5%.
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PMID:A respiratory survey of cedar mill workers. I. Prevalence of symptoms and pulmonary function abnormalities. 65 Mar 5

To discover the prevalence of chronic respiratory disease and the various factors associated with it, 1162 men (85% of the defined population) aged 25 to 69 years were surveyed using a questionnaire, chest radiograph and spirometry. 112 men with pulmonary tuberculosis or "other respiratory disease" were excluded from the analysis. Excluding the youngest age group (25 to 39 years), the smokers were thinner than the non-smokers. The percentages of overweight men among the non-smokers, ex-smokers and smokers were 22%, 27% and 14%, respectively (P less than 0.001). Almost all respiratory symptoms were more common in the smokers than in the non-smokers, and the prevalence of cough, phlegm, severe breathlessness and the effect of weather on respiratory symptoms significantly increased with age. Asthma was not associated with age or smoking, nor was socioeconomic status associated with chronic respiratory disease. The ventilatory function, measured by FEV1, FVC and FEV%, was worse in the smokers than in the non-smokers. In addition the slope of FEV% on age was significantly steeper in the ex-smokers and the various groups of smokers than in the non-smokers.
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PMID:Chronic respiratory disease in rural men. An epidemiological survey at Hankasalmi, Finland. 67 6

73 welders were examined, who weld in an assembly room of a machine factory, mainly by an electric arc. In anamneses 60% of persons under examination notified of coughing, expectorating, dyspnoea during work, and frequent acute rhinitis. Clinical symptoms of respiratory tract disease, resulting from welding, were found in 10% of welders. Simple bronchitis, resistant bronchitis with pulmonary emphysema, pleural adhesions were diagnosed. In one case fibronodular tuberculosis was found (1%). In 8% of workers, aged 40--50, a dynamic arterial hypertension and radiological symptoms of aortosclerosis were found. 5% welders had granulocytopenia. Disturbances of the examined systems occurred in factory welders with duration of employment above 10 years.
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PMID:[Health conditions of a group of factory arc welders]. 68 52

Pulmonary disease has been associated with several chemotherapeutic agents but has not been reported in patients receiving the alkylating agent mitomycin (Mutamycin). We describe here the cases of three patients who developed interstitial pneumonia while receiving mitomycin therapy. Their clinical features including dyspnea, cough, and occasionally fever; reticular infiltrates were seen on chest roentgenogram. Histologically, diffuse alveolar septal edema, mononuclear-cell interstitial infiltrates, hypertrophy of alveolar lining cells, and alveolar septal collagen deposition were characteristic. Treatment with corticosteroids was associated with a rapid therapeutic response in all three patients.
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PMID:Interstitial pneumonia from mitomycin. 68 48

The clinical and physiologic effects of bronchopulmonary lavage of both lungs at separate times in 14 patients with alveolar proteinosis proved by biopsy were followed for 2 to 96 months. Before lavage, all patients had moderate to severe dyspnea on exertion. Twelve had a nonproductive cough, and 2 had a productive cough; both were smokers. Nine had generalized fatigue, and 4 had weight loss. Twelve of 14 had fine inspiratory rales. All of the patients had abnormal chest roentgenograms, and 13 of 14 had an increased lactate dehydrogenase concentration. After lavage, all patients had loss of fatigue and improved exercise tolerance, with most returning to normal activity. Cough cleared in 12 of 14 and remained only in the cigarette smokers. Inspiratory rales cleared completely in most patients (11 of 12) and partially in one. The rales usually returned during exacerbations. Physiologic measurements that changed significantly after bilateral lavage included: vital capacity, total lung capacity, resting room air PO2, exercise PO2, PO2 while breathing 100 per cent O2, and DLCO. Because all measurements were made within 5 days of the second lavage, one must attribute the acute improvement to the removal of proteinaceous material from the alveoli. The long-term effects varied; some patients required annual or semiannual lavages, wherease others remained in remission after lavage for 36 to 96 months. Exacerbations were accompanied by increased dyspnea, reappearance of rales, and deterioration of the gas-exchange parameters noted previously. Repeat lavage reversed the clinical symptoms and physiologic abnormalities in patients who had recurrences.
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PMID:Physiologic effects of bronchopulmonary lavage in alveolar proteinosis. 69 76

Stage I sarcoidosis usually presents with roentgenographic evidence of hilar adenopathy and the patients are totally asymptomatic. However, five patients were studied at the Mayo Clinic who had stage I sarcoidosis associated with obstructive disease of the airways. Four of the five presented with dyspnea, wheezing, and cough, and they were found to have expiratory slowing on physical examination. One patient was asymptomatic and her physical examination was normal. On pulmonary function testing, she had a decrease in maximal midexpiratory flow, and at fiberoptic bronchoscopy, mucosal changes consistent with noncaseating granuloma of sarcoidosis were seen. All five patients had the classic roentgenographic appearance of sarcoidosis, with hilar and right paratracheal adenopathy. Endobronchial involvement is well known in sarcoidosis, but its significance in stage I disease has not been emphasized in the literature. An awareness of this possibility is important because it may be an indication for bronchoscopy and mucosal biopsy in the patient with stage I sarcoidosis, particularly when the patient presents with dyspnea, wheezing, and cough. Also, corticosteroid, therapy may be indicated in selected patients with stage I sarcoidosis.
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PMID:Obstructive disease of the airways associated with stage I sarcoidosis. 73 55

A cohort of medical students first seen in 1962 has now been examined for a third time. The prevalence of symptoms of cough, phlegm, and breathlessness among them has remained low, and smoking habits have been light in comparison with those of the general population. Results of the three successive sets of measurements of lung function indicate that, in general, optimum values were reached in the early 20s, with little further change up to age 29. There was some evidence of reduced ventilatory capacity in subjects with histories of acute chest illnesses.
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PMID:Respiratory function measurements in a cohort of medical students: a ten-year follow-up. 74 4

Six patients with chronic cough, without history of dyspnea or wheezing, had normal base-line spirometry but hyper-reactive airways, as demonstrated with methacholine. Maintenance therapy with bronchodilators promptly eliminated the cough in all patients. Three to 12 months later therapy was discontinued for three days, cough returned, and detailed pulmonary-function studies were carried out. Again, base-line values were normal, but after methacholine one-second forced expiratory volume decreased an average of 40 per cent in the patients as compared to 30 per cent in normal controls (P less than 0.001). The point of identical flow was increased by methacholine to 43.5 per cent of vital capacity in the patients, as compared to 6 per cent in normal controls (P less than 0.001), and the alveolar plateau was 4.8 deltaN2 per liter, as compared to 1.4 in normal controls (P less than 0.01). Specific airway conductance was lowered in patients and controls, but the post-methacholine value was significantly lower in the patients. On the basis of their persistently hyper-reactive airways, inducible diffuse airway bronchoconstriction and excellent response to bronchodilator therapy, these patients appear to have a variant form of asthma in which the only presenting symptom is cough.
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PMID:Chronic cough as the sole presenting manifestation of bronchial asthma. 76 86

The clinical results and changes in sputum found in both a short-term inpatient trial and a subsequent long-term outpatient investigation (three-month double-blind controlled study) of 82 patients with chronic bronchitis treated with a new mucolytic agent, S-carboxymethylcysteine (Mucodyne), are reported. Fluidification of sputum with reduction in certain measurements of the viscosity of morning sputum aliquots, associated with improvement in the ability to cough up bronchial secretions, significant increase in sputum volume output, and improvement in ventilation (as estimated by the forced expiratory volume in one second), were observed in both trials as dose-related responses, with an increase in the ease of expectoration and a reduction in cough frequency and dyspnea. Therapy with S-carboxymethylcysteine was well tolerated, and there were no serious adverse effects, either immediate or delayed. We suggest that the effect of the drug in fluidifying sputum may be due to a mucoregulatory mechanism which reverses the sputum macromolecular disturbances seen in chronic bronchitis.
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PMID:S-carboxymethylcysteine in the fluidification of sputum and treatment of chronic airway obstruction. 78 27


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