Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adult subjects, without age or sex distinction, presenting a non-specific chronic laryngitis were treated with SOLACY. The posology of SOLACY administered was: 2 capsules in the morning and 2 at night for four months in a row. The subjects were seen at least twice: one consultation before the treatment and one after the 4 months of treatment. These consultations included an interview and fibroscopic test of the laryngeal mucosa (photographs were taken). The subjects were also requested to quantify the overall discomfort experienced. Ten subjects were recruited for this study. Dysphonia was significantly lower after the 4-month treatment as was the self-evaluation of the overall discomfort brought on by the different symptoms. In addition, it can be noted that SOLACY lessened coughing and laryngeal discomfort in most of the patients treated and it improved the fibroscopic test results, especially concerning the congestive aspect of the laryngeal mucosa, whether limited to vocal chords or spread throughout the entire vestibule. The treatment was tolerated perfectly well. In conclusion, SOLACY, administered in adults presenting non-specific chronic laryngitis improves the state of the laryngeal mucosa and its main symptoms (dysphonia, coughing, laryngeal discomfort).
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PMID:[Solacy and non-specific chronic laryngitis]. 263 59

Neurogenic dysphagia following stroke is not limited to brainstem involvement. Among 21 patients with stroke, one-third demonstrated only unilateral signs. In eight patients with silent aspiration, less subjective complaints, weaker cough, and dysphonia occurred more often. Videofluoroscopy must be used liberally in unilateral and bilateral strokes.
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PMID:Silent aspiration following stroke. 334 Mar 1

Rare upper airway lesions may be mistaken for asthma. A 16-year-old Hispanic male athlete presented to our allergy clinic with a 4-month history of wheezing and snoring with hoarseness and progressive fatigue on exertion or during sleep. His mother taped periods of harsh stridor and sleep apnea. There was no family history of vocal cord abnormalities. A year before the onset of symptoms, he suffered injury to his oral cavity with a loss of consciousness during a wrestling match. He denied dysphagia or dysphonia. He failed to respond to bronchodilators, cromolyn, or prednisone therapy during 4 weeks. On referral to our clinic, his physical examination and tape recording were characterized by harsh inspiratory stridor. His pulmonary function tests were significant for peak flow depressed out of proportion to FEV1 with reduced FVC, no response to bronchodilator, and flattened inspiratory loop unresponsive to cough or panting. Fluoroscopy and endoscopy of the upper airway was consistent with "marked bilateral limitation of vocal cord abduction." Sleep study demonstrated desaturation with CO2s in the 60s during sleep. He was started on continuous positive airway pressure, 10 cm at night, with no desaturation or sleep disturbance on follow-up.
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PMID:Bilateral abductor paresis masquerading as asthma. 337 24

Paradoxical vocal cord motion (PVCM) is an important cause of laryngeal stridor and dysphonia; however, only two previous cases have been reported. We report three additional cases, one of which was tracheotomized on two occasions before the diagnosis was made. These patients, typically young females who have had a recent upper respiratory infection, present with stridor. They can phonate weakly, but they cannot cough. Indirect laryngoscopy reveals smooth, symmetric vocal cord adduction on inspiration and abduction on expiration. Laboratory values are normal. PVCM appears to be self-limited (up to 72 hours), and patients respond to supportive care and sedation. Tracheotomy appears to be unnecessary. The etiology is obscure and may be functional; however, a case is discussed in which PVCM was seen in association with chronic aspiration in a patient with organic brain syndrome. An awareness of this entity and a high index of suspicion can prevent unnecessary tracheotomy.
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PMID:Paradoxical vocal cord motion: an important cause of stridor. 716 97

Reports on the surgical management of the vascular ring formed by the right aortic arch with aberrant retroesophageal left subclavian artery and left ligamentum arteriosum are relatively few. The authors present a case of a thirty-three-year old woman with cough, dysphonia and stridor without dysphagia. Surgical management which was performed through a bilateral thoracotomy with transversal sternotomy, included division of the ligamentum arteriosum and of the aberrant left subclavian artery and suture of the latter. There was no need to resect the Kommerell's diverticulum, because of lack of any dysphagia despite of the well documented severe compression of the esophagus. The authors experience proved that in difficult cases the bilateral thoracotomy and transversal sternotomy is an useful approach to perform complete surgical repair of this abnormality.
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PMID:[The surgical correction of the right aortic arch with aberrant left subclavian artery and left ligamentum arteriosum--a rare case from clinical practice]. 747 58

The aim of the study was to assess the prevalence of throat and voice symptoms in asthma patients using pressurized aerosol, metered-dose, inhaled corticosteroid preparations. A questionnaire was administered to hospital out-patients in an asthma clinic and to a control group attending a diabetic clinic. Two hundred and fifty five consecutive out-patients using pressurized aerosol inhaled corticosteroids and 100 controls were surveyed. One hundred and forty seven (58%) patients taking inhaled steroids reported voice dysphonia or throat symptoms compared with 13% of control patients. Women admitted to symptoms more frequently than men. Throat symptoms were more prevalent in patients using higher doses of inhaled steroid. Aerosol inhaler-induced cough was reported by 87 (34%) patients. Local side-effects were equally prevalent both with beclomethasone dipropionate and budesonide aerosol inhalers. The use of a large volume spacing device with either steroid aerosol did not appear to protect against these symptoms. Local side-effects are common in asthmatics taking pressurized aerosol, metered-dose, inhaled steroids.
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PMID:Frequency of voice problems and cough in patients using pressurized aerosol inhaled steroid preparations. 766 59

Laryngeal paralysis is now a frequently recognized disorder, particularly in older dogs of certain breeds such as the Labrador retriever, Afghan Hound and Irish Setter. The presenting signs may consist of exercise intolerance, inspiratory stridor, inspiratory dyspnoea, gagging, coughing and dysphonia. Two forms of laryngeal paralysis exist, hereditary and acquired. The hereditary form is found in young dogs and transmitted by an autosomal dominant gene. At present little is known about the aetiology of acquired laryngeal paralysis and therefore treatment is directed at relieving the laryngeal obstruction. Recent reports indicate that arytenoid lateralization achieves the best results as a method of surgical correction.
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PMID:A review of laryngeal paralysis in dogs. 773 72

A 72-year-old woman with severe rheumatoid arthritis developed atlantoaxial subluxation requiring surgery. Tracheal intubation was performed during the procedure. Gradually worsening dysphonia and dyspnea developed postoperatively. Laryngoscopy showed palsy of both vocal cords and coalescence of the arytenoid cartilages. Despite surgical treatment, permanent tracheostomy was required. There is evidence that laryngeal involvement is common but usually subclinical or mild in rheumatoid arthritis patients. Tracheal intubation can cause the laryngeal lesions to flare. Clinical manifestations are nonspecific and sometimes misleading (e.g., cough or pharyngeal and laryngeal pain). Direct laryngoscopy and computed tomography of the larynx allow evaluation of the lesions of the different components of the larynx. The case reported herein demonstrates that rheumatoid arthritis patients should be screened for laryngeal involvement by history and ENT examination and that any laryngeal abnormalities should be reported to the anesthesiologist if tracheal intubation is planned.
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PMID:[Severe laryngeal involvement in rheumatoid arthritis requiring permanent tracheostomy]. 783 91

A 52-year-old man with intractable cough refractory to standard therapy was treated successfully with chronic nebulized lidocaine. He has experienced no adverse effects from the lidocaine except for occasional mild dysphonia. Measured serum levels of lidocaine after treatment have never exceeded 4.0 mg/dl. This case shows prolonged therapy with nebulized lidocaine is a safe and effective treatment for refractory cough.
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PMID:Nebulized lidocaine in the treatment of refractory cough. 891 54

We have found that Teflon granulomas and the overinjection of Teflon with the resulting laryngeal dysfunction, although uncommon, present a challenge to the otorhinolaryngologist, due in large part to the inflammatory reaction to the injected Teflon. This report addresses the management of 16 patients (12 women and 4 men) treated surgically for symptoms secondary to Teflon granulomas or vocal folds that had been overinjected with Teflon. The presenting symptoms varied and included airway obstruction, cough, choking, swallowing difficulties, and dysphonia. In each case the granuloma and Teflon were removed endoscopically via a lateral cordotomy. A second procedure to address dysphonia due to vocal cord lateralization was frequently required and presents the challenge for the surgeon to select the appropriate procedure and time of intervention. The results of this retrospective review suggest that resolution of inflammatory changes and fibrosis subsequent to Teflon removal requires significant lengths of time and that thyroplasty techniques provide a means for medialization without reintroduction of the original inflammatory material.
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PMID:Teflon granulomas and overinjection of Teflon: a therapeutic challenge for the otorhinolaryngologist. 821 92


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