Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Synovial sarcomas arising in unexpected locations may lead to diagnostic challenges. In this report, we describe 3 cases of synovial sarcoma that manifested clinically as primary pericardial lesions. All 3 cases occurred in men in their fourth decade. Fever, cough, chest pain, and chest distress were the most common symptoms. Histologically, 2 of the tumors were spindle cell monophasic, and 1 tumor was biphasic. By immunohistochemical studies, the tumor cells were positive for cytokeratins and epithelial membrane antigen. In addition, the tumor cells displayed focal immunoreactivity for calretinin, cytokeratin 5/6, and HBME-1, resulting in the initial interpretations of malignant mesotheliomas. None of the 3 cases were diagnosed correctly until subsequent molecular cytogenetic assays demonstrated the presence of SYT gene rearrangements. As there are overlapping morphologic features between pericardial synovial sarcoma and mesothelioma, molecular analysis is essential for differential diagnoses.
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PMID:Pericardial synovial sarcoma, a potential for misdiagnosis: clinicopathologic and molecular cytogenetic analysis of three cases with literature review. 2218 Apr 88

Synovial sarcomas are rare malignant mesenchymal tumors that can arise from any anatomic site. Although they are often located at the paraarticular region of the extremities, the incidence of synovial sarcomas in the lungs is rare, with only a few cytology case reports to date. We report a case of synovial sarcoma presenting as a lung mass diagnosed on fine-needle aspiration (FNA) cytology. The patient is a 38-year-old chronic smoker who presented with cough, worsening dyspnea, and weight loss. Computerized tomography of his chest revealed an 8-cm left lower lobe pleural-based mass. An FNA of the lung mass showed cellular smears composed of monotonous population of singly scattered to sheets of bland spindle cells with elongated nuclei, fine chromatin pattern, and scant to moderate amount of delicate cytoplasm. Immunohistochemical stains performed on the cell block showed that the tumor cells were positive for calretinin and focally positive for pancytokeratin, CAM5.2, and smooth muscle myosin heavy chain. The tumor cells were negative for S-100, podoplanin, and CD34. Fluorescence in situ hybridization performed on the cell block demonstrated the presence of SYT (18q11) translocation, supporting the diagnosis of synovial sarcoma.
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PMID:Cytological findings of monophasic synovial sarcoma presenting as a lung mass: report of a case and review of the literature. 3117 83

Primary intra-abdominal synovial sarcomas are rare soft tissue malignancies. Herein, we present a case of poorly differentiated monophasic synovial sarcomain ileum mesenterieswith pulmonary metastasis. The patient was a 47-year-old female with a history of cough with variable expectoration and paroxysmal abdominal pain for two months. The tumor was located in ileum mesenteries and composed of monophasic spindle tumor cells with active mitosis and massive necrosis. Tumor cells were positive for vimentin and BCL-2 by immunohistochemistry staining and positive for SYT gene break apart by dual color break apart fluorescence in situ hybridization assay. The differential diagnosis includes gastrointestinal stromal tumour and other mesenchymal tumour.
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PMID:Primary poorly differentiated monophasic synovial sarcoma of ileum mesenteries with pulmonary metastasis: a case report. 3196 64