Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report two cases of necrotizing bronchiolitis and bronchiolitis obliterans associated with the finding of the fungus aspergillus. One of the cases also showed bronchiolocentric granulomas and mucoid impaction of a segmental bronchus. Both patients were immunocompromised and had presented with dyspnea, cough, fever, and pulmonary infiltrates. Systemic antifungal therapy led to symptomatic and radiologic resolution. We surmise that these cases represent unusual examples of chronic necrotizing aspergillosis. The spectrum of pulmonary aspergillus diseases is reviewed.
Conn Med 1994 Jan
PMID:Bronchiolitis associated with the finding of the fungus aspergillus. Report of two cases. 818 Dec 71

A group of operating room personnel at a medical center in Connecticut reported severe respiratory irritation manifested by either proxysmal cough or throat irritation suggestive of a noxious fume exposure, 13 April 1994. However, persistent complaints on 14 April 1994 were significantly different and more suggestive of a psychological reaction. By careful interviewing, physical examination, toxicological assays, and epidemiological investigation, the true nature of a mixed physiological and psychological episode was delineated. Enlightened management policy enabled rapid restoration of return to work with minimal economic loss.
Conn Med 1998 Feb
PMID:Noxious fumes in a medical center: chemical and psychological aspects. 954 87

A 55-year-old man presented to his primary care provider after a two-week history of worsening cough. He was admitted to the hospital and treated for community acquired pneumonia due to progression of symptoms and an abnormal chest radiograph. Chest computerized tomography demonstrated a large consolidation in the right upper lobe with areas of cavitation consistent with necrosis. Blood and sputum cultures were obtained, and the patient was subsequently diagnosed with pulmonary Salmonella typhimurium infection. The organism was isolated from a sputum specimen only. The patient had a history of chronic alcoholism, bronchitis, and esophageal dysmotility but no evidence of severe immunosuppression or malignancy. The patient responded well to antibiotic therapy with both symptomatic and radiologic improvement. As pulmonary Salmonella infection is exceedingly rare in the immunocompetent patient, a review of the literature is presented.
Conn Med 2008 Mar
PMID:Salmonella typhimurium pulmonary infection in an immunocompetent patient. 1861 Jul 17

We present an interesting case of tracheobronchial foreign body aspiration. A 29-year-old healthy female, with no history of pulmonary disease, presented on multiple occasions to healthcare providers with wheezing and cough. She was repeatedly diagnosed and treated for asthma with acute exacerbations. Upon further evaluation, the patient was subsequently found to have a tracheobronchial foreign body causing her symptoms. This case report highlights a clinical approach to wheezing illnesses and reviews the diagnosis and management of tracheobronchial foreign body aspiration.
Conn Med 2011 Sep
PMID:"A dropped call". 2198 Jun 74

Organ transplant recipients are at an increased risk for subsequent malignancies including hematologic malignancies. The development of acute myeloid leukemia (AML) after solid organ transplantation is a rare but well-documented event. It is thought to be a consequence of immune dysregulation secondary to the use of immunosuppressive agents. Herein, we present the management of a liver transplantation recipient who presented with AML and comprehensively review the relevant literature. A 59-year-old male patient presented with fever and cough eight years after an orthotopic liver transplantation for cirrhosis and hepatocellular carcinoma. He received methylprednisolone and mycofenolate mofetil (MMF) followed by tacrolimus and rapamycin as immunosuppression. Upon admission to our hospital, his peripheral blood demonstrated 34% blasts and pancytopenia. A bone marrow biopsy confirmed the diagnosis of myelodysplastic syndrome (MDS) in transformation to AML. He was treated with induction chemotherapy and his sirolimus was continued but he expired four weeks after from refractory disease. No specific guidelines exist for the treatment of AML in solid organ transplant recipients. Treatment should be individualized and concurrent use of chemotherapeutic and immunosuppressive agents should be carefully balanced.
Conn Med 2012 Mar
PMID:Acute myeloid leukemia following solid organ transplantation: case report and comprehensive review. 2266 74

Hemoptysis, a common sign of diffuse alveolar hemorrhage, can be caused by multiple factors, both infectious and noninfectious. A 45-year-old male with hypertension, obstructive sleep apnea, and stage IV pulmonary sarcoidosis with cardiac involvement, presented with a two-month history of cough and acute nonmassive hemoptysis with hypoxia. A chest CT showed ground glass consolidation and interlobular septal thickening, concerning for diffuse alveolar hemorrhage. Flexible bronchoscopy confirmed diffuse alveolar hemorrhage; microbiological analyses of bronchoalveolar washings did not reveal a causative organism. Mycoplasma pneumoniae-specific IgM in serum studies was consistent with mycoplasma pneumonia as the most likely etiology of this patient's diffuse alveolar hemorrhage and resultant hemoptysis. This report points to the need to consider atypical mycoplasma pneumonia as a possible etiology of hemoptysis in patients with underlying sarcoidosis.
Conn Med 2016 Mar
PMID:An Atypical Case of Hemoptysis. 2716 98

Solitary fibrous tumors ofthe pleura (SFTP) are uncommon. They tend to be discovered incidentally or during workup for unexplained cough or paraneoplastic effects. It is important to recognize the entityand perform a surgical excision because of the possibility of subsequent malignant transformation and local compressive effects. We present the case of a SFTP discovered on chest imaging. Our patient had surgical excision with good response. A review of the literature is also presented.
Conn Med 2017 Jan
PMID:Solitary Pleural Fibroma: A Case Report and Review of Literature. 2978 61