Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Carcinoma with thymus-like differentiation (CASTLE) is a rare malignant epithelial tumor which arises on soft tissue of the neck or thyroid gland. It is important to differentiate CASTLE from primary or metastatic squamous cell carcinoma of head and neck, and from squamous cell thyroid carcinoma, because it has a different prognosis. CD5 immunoreactivity might be helpful in CASTLE diagnosis. CASTLE behaves generally in an indolent fashion, even though it has a high relapse rate, while the other have a dismal prognosis due its high dissemination rate. Treatment includes surgical excision and radiotherapy. Chemotherapy can be offered, although its efficacy is not clear. Authors present a case of a 52 year-old male that complaints with cough, disphony, asthenia, and thyroid mass. Thyroidectomy was performed and the pathology revealed a CASTLE. After radiotherapy and chemotherapy, minimal response was obtained. The authors intend to discuss the differential pathologic diagnosis and the best therapy of this indolent but recurrent neoplasm, that demands strict long term follow-up.
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PMID:[Thyroid carcinoma with thymus-like differentiation (CASTLE): case report and review of the literature]. 1850 81

Carcinoma showing thymus-like differentiation is a malignant, extremely rare neoplasm that arises in the thyroid gland or neighboring neck soft tissue and closely resembles thymic carcinoma. Long-term survival is possible if the disease is diagnosed early and is completely resected, followed by radical dose radiotherapy. We present the case report of a 65-year-old man who presented with neck mass and neck pain that increase with intensity with cough. He was evaluated by thyroid ultrasound, which showed an echogenic nodule. Baseline PET/CT imaging revealed a very hypermetabolic lesion in the right lobe of the thyroid gland.
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PMID:FDG PET/CT of carcinoma showing thymus-like differentiation. 2269 25