Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During eight weeks of a recent influenza epidemic 29 patients with ketoacidosis were admitted to the General Hospital, Birmingham. This was an exceptionally large number of cases. Of these, 14 had complained of a cough, nine had clinical evidence of respiratory infection, and four extensive bronchopneumonia. Hypokalaemia was present on admission in several instances and caused respiratory failure and death in three patients. Since the dangers of initial hypokalaemia are increased during the treatment of ketoacidosis, especially when sodium bicarbonate is used, serum potassium levels must be estimated initially and, if necessary, potassium chloride given intravenously at more frequent intervals than usual.
 ...
PMID:Diabetic ketoacidosis during the influenza epidemic. 499 May 51

We administered 45 Nd-YAG laser treatments in 29 patients (18 men) aged 39 to 82 years who had lung malignancy; 26 patients had primary non-oat cell lung cancer and three had metastatic airway malignancy. In all, 25 of the patients had been previously treated with combination(s) of surgical procedure, radiation therapy and chemotherapy. Indications for laser treatment included endobronchial airway obstruction with uncontrolled cough, hemoptysis, dyspnea or unresolved atelectasis-pneumonia. Of 15 patients with partially occluded tracheobronchial airway tumors, immediate palliative relief was achieved in 13 patients and lasted one to six months after a single treatment. In this group there was one postoperative death related to respiratory failure and two patients subsequently died of massive pulmonary hemorrhage. However, of 14 patients with totally obstructed airways, immediate palliative relief was achieved in only five patients and this lasted three weeks to three months after a single treatment. In this group there were two postoperative deaths related to progressive respiratory failure; in one case it was associated with endobronchial combustion of the fiberoptic bronchoscope. All three patients in both groups who died of respiratory failure were in acute respiratory distress and terminally ill before the procedure. These findings suggest that Nd-YAG laser therapy may be most beneficial in patients with partially rather than totally occluded airways due to lung malignancy.
 ...
PMID:Nd-YAG laser in lung cancer. 620 Oct 11

A case is presented, of a patient with acute fungal pneumopathy. The evolution of the disease in this 63 years male was short and rapid, characterized by fever, dyspnea, thoracic pain, muco-purulent expectoration and intense coughing. In spite of the complex treatment applied the patient died with acute cardio-respiratory failure. The radiological examination revealed micro-nodular and nodular opacities extending predominantly in the left lung. Laboratory investigations included a microbiologic study for the Koch bacillus, which was negative. The post-mortem examination revealed multiple focuses with suppurative aspects on a diffuse background of hepatization. The microscopic examination evidenced the presence in the respective focuses of abundant colonies of Candida and Aspergillus, and a hematogenic invasion with Candida and allowed to determine a diagnosis of acute pneumopathy of fungal origin as a result of a double infection with Candida and Aspergillus strains.
 ...
PMID:[Acute fungal pneumopathy caused by Candida and Aspergillus (case report)]. 629 80

The amount of oxygen in mixed venous blood (SvO2) is a reliable indicator of the status of oxygenation of tissue in most clinical settings. Monitoring levels of SvO2 might, therefore, aid in managing critically ill patients. A recently developed adult pulmonary arterial catheter provides continuous measurement of SvO2 via fiberoptic bundles incorporated into the catheter, in addition to measuring hemodynamic pressures and cardiac output by thermodilution. We evaluated 100 consecutive fiberoptic catheters for accuracy and reliability of the system in 86 critically ill adult patients and determined the clinical usefulness that knowledge of SvO2 provided. Over a range of hemoglobin saturations from 24 to 85 percent, the correlation coefficient between in vivo SvO2 vs photometrically measured samples for 199 paired measurements was 0.95. Mean duration of usage for 33 catheters in the medical intensive care unit was 6.1 days; all catheters functioned normally until clinical conditions permitted removal. Continuous measurements of SvO2 detected unsuspected increases in tissue oxygen consumption during coughing spasms and positioning of the patient. In nine of 13 patients with hypoxemic respiratory failure requiring positive end-expiratory pressure (PEEP), we found a strong correlation (r = 0.88) between oxygen delivery and SvO2. Of the four patients not showing correlation, two had sepsis, and two had nearly normal values of SvO2 and oxygen delivery at all levels of PEEP studied. Continuous measurement of SvO2 improves monitoring of patients, facilitates titration of respiratory therapies, detects abrupt changes in tissue oxygen consumption, and identifies levels of PEEP associated with greatest oxygen delivery.
 ...
PMID:Clinical experience with continuous monitoring of mixed venous oxygen saturation in respiratory failure. 648 14

Desquamative interstitial pneumonia occurred in three siblings. Cough, difficulty in breathing, cyanosis, and failure to gain weight appeared during the first month of life; progressive hypoxia followed, and the three infants died in respiratory failure before the age of 4 months despite intensive drug and supportive treatment. The radiographic and the histologic appearance of pulmonary changes were similar in all three infants. Chest radiographs yielded normal findings initially, with rapid progression to a ground glass appearance of both lungs. Histologic findings of lung biopsies showed lymphoplasmocytic infiltration and fibrous thickening of the alveolar walls, swelling of alveolar lining cells, and large clumps of macrophages with PAS-positive foamy cytoplasm in the alveolar spaces.
 ...
PMID:Fatal desquamative interstitial pneumonia in three infants siblings. 672 19

A program of respiratory muscle sparing in 9 patients with late stage Duchenne muscular dystrophy is presented. Results indicate that regular efficient night-time support by body respirator provides a constant significant improvement in daytime gas exchange for periods averaging up to 2 years following the occurrence of moderately severe respiratory failure. Until now, the longest survival is more than 4 years at the age of 28. the average PaCO2 and PaO2 before night ventilation were 60.8mmHg and 59.3mmHg, respectively. The levels after the program was begun were 45.5 (PaCO2) and 74.6 (PaO2). These arterial blood gas levels are acceptable for good cardiopulmonary homeostasis. There have been no deaths or episodes of cardiac failure since the program began. The ease of integrating the program into the patient's lifestyle and home are important advantages. Cost of equipment is discussed. The view that these patients are terminal must be qualified. A case is also made for early aggressive conservative measures including body respirators, postural drainage, chest physiotherapy with abdominal assisted coughing, intratracheal suctioning and bronchoscopy to combat respiratory infection, and decreasing the need of tracheostomy and volume ventilators which can be so disabling to the chronic restrictive lung disease (CRLD) patient. Research and development into better design of body respirators is vitally needed. Acute care hospitals must prepare themselves for such patients who now attain more independent living and longer lifespan. For this reason there is a growing need for these facilities to acquire tank ventilators for handling such patients who may need hospitalization for acute medical complications.
 ...
PMID:Night ventilation by body respirators for patients in chronic respiratory failure due to late stage Duchenne muscular dystrophy. 678 53

We studied the effect of adding positive end expiratory pressure, PEEP, during the administration of a nebulized bronchodilator in eight patients with acute respiratory failure and severe bronchospasm. Respiratory failure was diagnosed by means of an arterial blood gas analysis and bronchospasm by the presence of wheezing, dyspnea, cough and a forced expiratory volume in the first second, FEV1, of less than 0.7 L. A randomized cross over design was used, where each patient was subjected to two PEEP treatments and two control treatments with zero end expiratory pressure, ZEEP. The interval between each treatment was three hours. With ZEEP, FEV1 rose from 0.69 +/- 0.31 to 1.03 +/- 0.23 L and with PEEP from 0.66 +/- 0.28 to 1.50 +/- 0.48 L (P less than 0.05). Similar changes were seen in forced vital capacity and in peak flow. These results demonstrate that PEEP improves the efficacy of an inhaled, nebulized bronchodilator. This effect is probably mediated through a better distribution especially in peripheral airways.
 ...
PMID:A new mode of administration of nebulized bronchodilator in severe bronchospasm. 704 90

After wide excision of the chest wall for primary tumour or bronchopulmonary carcinoma involving the ribs, the gap must be filled to prevent paradoxical respiration and its immediate functional consequences during the post-operative period. This can easily be achieved by using a polyglactin 910 piece of net cut to size out of a 25 X 25 cm plaque and sutured between the ribs under tension. The prosthesis ensures thoracic stability and acts as support for re-adherence of the lung to the chest wall. It resists coughing and is well tolerated. The indications of choice are respiratory failure and excision performed in varying degrees of septic condition which make non-absorbable material unsuitable. Another indication is wide excision of a tumour-invaded pericardium with herniation of the heart.
 ...
PMID:[Repair of loss of substance of the thoracic wall and pericardium using a net of resorbable material]. 715 28

Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progressing to interstitial pulmonary fibrosis. Corticosteroid therapy resulted in complete resolution of pneumonia in one patient. Respiratory symptoms improved in 3 patients following discontinuation of the drug. Two patients with extensive bilateral pneumonitis, who were not treated with steroids, died of respiratory failure. Mitomycin-induced lung toxicity appears to be reversible with the discontinuation of drug and the administration of corticosteroids. Lung biopsy is necessary in order to rule out other diagnoses.
 ...
PMID:Pulmonary toxicity of mitomycin. 735 Oct 10

Report on a case of a woman suffering from trifacial neuralgia who was treated with Carbamazepin (Tegretal). Following therapy there occured dyspnea and cough, followed by a considerable reduction of the pulmonary function. The symptoms were caused by a probably allergic interstitial pneumonia induced by Carbamazepin. The onnexion between Carbamazepin and respiratory failure could be established by reexposition. This side-effect of Carbamazepin is a very rare event.
 ...
PMID:[Case of carbamazepine-induced interstitial pneumonia]. 736 17


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>