Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Amyopathic dermatomyositis (ADM) is a clinical subtype of dermatomyositis, characterized by the absence of motor weakness and the presence of normal muscle enzyme levels. ADM is sometimes accompanied by neoplasm or interstitial pneumonia that shows a rapid progressive course both of them are associated with a poor prognosis. A 56-year-old woman with no medical history was referred to the department of medicine because of arthralgia with a remarkable weight loss. She also complained of rapidly progressive dyspnea, cough and photosensitivity. Physical examination on admission showed scaly erythema on the dorsum of the hands (Gottron sign) and periorbital edema with a purplish appearance (heliotropic rash), arthritis, but no muscle weakness. Auscultation of the chest identified audible fine crackles on the lower aspects of both lungs. Results of laboratory findings on admission revealed a lymphopenia. The serum creatine kinase and serum lactate dehydrogenase concentration were normal. IRM muscle and electromyography were normal. Antinuclear antibody was positive 1:80 and anti-Jo-1 antibody and other autoantibodies to specific antigens were all negative. High resolution computed tomographic chest scans also revealed diffuse ground-glass opacities in both lungs with basilar predominance. Arterial blood gas analysis revealed hypoxia and hypocapnia. LBA was not performed because of the deterioration of respiratory symptoms. There was no neoplasm associated. The diagnosis of ADM complicated with ADM rapidly progressive interstitial pneumonia was made. Despite of IV methylprednisolone pulse therapy (1g*day-1 for 3 days) and cyclophosphamide, she died by respiratory failure.
 ...
PMID:[Interstitial pneumonia complicating amyopathic dermatomyositis: a case report]. 1999 56

Amyopathic dermatomyositis (ADM) is a variant of dermatomyositis that is characterized by the typical skin rash but without the muscle abnormalities. We report a case of ADM complicated with interstitial pneumonitis (IP) and lung cancer. A 73-year-old female was hospitalized for skin rash and dry cough. Skin biopsy findings were compatible with dermatomyositis though no subjective and objective findings suggestive of skeletal muscle involvement were noted. Chest computed tomography (CT) revealed a consolidation of her right upper lung and irregular opacity of bilateral lower lobe. By histopathological evaluation, she was diagnosed as lung cancer with ADM. Therapy consisting of prednisone was begun. Two weeks after the surgery, dry cough progressed. Her acute exacerbation of IP did not respond to the therapy and passed away by disseminated intravascular coagulation and respiratory failure.
 ...
PMID:[Post-operative acute exacerbation of interstitial pneumonea associated with amyopathic dermatomyositis]. 2066 33