Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0010200 (cough)
 23,843 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Culturally appropriate health messages can make a huge difference in conveying health information on, for instance, acute respiratory diseases (ARI). In Bolivia, PLAN health projects are devoted to developing and implementing effective strategies to reduce infant and child morbidity and mortality. Acute respiratory disease are a major contributory cause. Health messages emphasize recognition by mothers of symptoms, such as prolonged coughing and fever and rapid breathing. The usual strategy promoted by the World Health Organization is to translate the messages into Spanish and print posters and training manuals. However, ARI has not been affected by such efforts. In Altiplano, a rural Aymara community, the community health workers receive this training in Spanish, but the Aymara idiom is used in this rural area. PLAN conducted an ethnographic study which revealed that pneumonia does not translate well into Aymara, and other less serious folk illnesses have similar symptoms. The solution was to promote the notion that rapid breathing was a serious problem, a solution not possible without linking indigenous and biomedical perspectives.
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PMID:Indigenous concepts useful in programs. Experiences in the Bolivian highlands. 1217 60

Acute respiratory disease caused by a novel coronavirus (SARS-CoV-2) has spread all over the world, since its discovery in 2019, Wuhan, China. This disease is called COVID-19 and already killed over 1 million people worldwide. The clinical symptoms include fever, dry cough, dyspnea, headache, dizziness, generalized weakness, vomiting, and diarrhea. Unfortunately, so far, there is no validated vaccine, and its management consists mainly of supportive care. Venous thrombosis and pulmonary embolism are highly prevalent in patients suffering from severe COVID-19. In fact, a prothrombotic state seems to be present in most fatal cases of the disease. SARS-CoV-2 leads to the production of proinflammatory cytokines, causing immune-mediated tissue damage, disruption of the endothelial barrier, and uncontrolled thrombogenesis. Thrombin is the key regulator of coagulation and fibrin formation. In severe COVID-19, a dysfunctional of physiological anticoagulant mechanisms leads to a progressive increase of thrombin activity, which is associated with acute respiratory distress syndrome development and a poor prognosis. Protease-activated receptor type 1 (PAR1) is the main thrombin receptor and may represent an essential link between coagulation and inflammation in the pathophysiology of COVID-19. In this review, we discuss the potential role of PAR1 inhibition and regulation in COVID-19 treatment.
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PMID:Protease-activated receptor 1 as a potential therapeutic target for COVID-19. 3330 37